王建斌博士
新世纪百千万人才工程国家级人选，国务院特殊津贴获得者, “赣鄱英才 555 工程”首批人选

● 教育与工作经历：

1981－1985，西南大学生物系，学士
1985－1988，山西大学生物系，硕士
1990－1995，香港中文大学生物科学系，博士
1996－1998，香港中文大学生物科学系，研究助理
1999－2000，美国纽约州立大学生物学系，博士后
2001－2009，美国康奈尔大学分子医学系，研究员
2010－2016，南昌大学转化医学研究院，特聘教授，副院长
2017－现在，南昌大学基础医学院，教授，博导，院长

● 研究兴趣、领域：

主要运用分子生物学、细胞生物学、动物模型和生物化学的手段研究肿瘤发生发展的分子机制，特别是基于肿瘤细胞中普遍存在的代谢异常的生化特征，系统研究这些特征与肿瘤的生长、侵袭和转移的关系，以及相关的信号转导
通路。 Rho GTPases 与肿瘤发生发展的关系。

● 代表性论文：

1. Tianyu Han, Weihua Zhan, Mingxi Gan, Fanrong Liu, Bentong Yu, Y. Eugene Chin &
Jian-Bin Wang*. Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and
critically contributes to tumorigenesis.
Cell Research (2018) 28:655–669; IF：15.6

2. Tianyu Han, Meng Guo, Mingxi Gan, Bentong Yu, Xiaoli Tian & Jian-Bin Wang*. TRIM59 regulates
autophagy through modulating both the transcription and the ubiquitination of BECN1. Autophagy
(2017). Accepted，IF：11.1


3. Weihua Zhan, Wenjuan Wang, Tianyu Han, Caifeng Xie, Tingting Zhang, Mingxi Gan, Jian-Bin
Wang. COMMD9 promotes TFDP1/E2F1 transcriptional activity via interaction with TFDP1 in
non-small cell lung cancer. Cellular Signalling (2017)，30: 59-66.

4. Tianyu Han, Meng Guo, Tingting Zhang, Mingxi Gan, Caifeng Xie, Jian-Bin Wang. A
novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung
cancer cells by targeting EGFR/ERK signaling pathway. Oncotarget (2017) Apr 25; 8(17):
28063–28073.

5. Guan, X.H., X. Hong, N. Zhao, X.H. Liu, Y.F. Xiao, T.T. Chen, L.B. Deng, X.L. Wang, J.B.
Wang, G.J. Ji, M. Fu, K.Y. Deng, and H.B. Xin, CD38 promotes angiotensin II-induced
cardiac hypertrophy. J Cell Mol Med (2017)

6. Caifeng Xie, Zhen Chen, Chengfu Zhang, Xin Xu, Jiangbo Jin, Weihua Zhan,
Tianyu Han, Jian-Bin Wang*. Dihydromyricetin ameliorates oleic acid-induced lipid
accumulation in L02 and HepG2 cells by inhibiting lipogenesis and oxidative stress. Life Sciences
(2016), 157: 131–139.

7. Caifeng Xie, Xujie Bao, Wei-Hua Zhan, Tian-Yu Han, Mingxi Gan, Chengfu Zhang,
Xiao-Jian Han and Jian-Bin Wang*.A novel glutaminase inhibitor-968 reverses acquired
erlotinib resistance by blocking glutamine metabolism in non-small cell lung cancer.
Oncotarget (2016), 7(1): 610-21

8. Weihua Zhan, Tianyu Han, Chenfu Zhang, Caifeng Xie, Mingxi Gan, Keyu Deng, Mingui Fu* and
Jian-Bin Wang*. TRIM59 inhibits the proliferation and migration of non-small cell
lung cancer cells by targeting cell cycle related proteins. Plos One (2015), 10(11):
e0142596

9. Xiao-Yu Wang1+, Ming-Xi Gan1+, Yong Li, Wei-Hua Zhan, Tian-Yu Han, Xiao-Jian
Han, Jin-Quan Cheng and Jian-Bin Wang*. Cdc42 induces EGF receptor protein accumulation
and promotes EGF receptor nuclear transport and cellular transformation. FEBS Letters (2014),
589（2）255-262.

10. Li Xiang and Jian-Bin Wang*. Maintenance of chaperone-mediated autophagy activity in
cultured cells expressing mutant huntingtin. Biomedical Reports (2014), 2: 529-532.

11. Han XJ, Yang ZJ, Jiang LP, Wang JB and Wan YY. Mitochondrial dynamics regulates
hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells.
International Journal of Oncology (2015), 46 (2): 691-700.


12. Tianyu Han+, De Kang+, Daokun Ji+, Xiaoyu Wang, Weihua Zhan，Mingui Fu, Hong-Bo Xin and
Jian-Bin Wang*. How Cancer Cell Metabolism Affects Tumor Migration and Invasion. Cell Adhesion &
Migration (2013), 7(5)：395-403.

13. Wang J. B., Erickson, J. W., Fuji, R., Ramachandran, S., Gao, P., Dinavahi, R., Ambrosio, A.
B., Dias, S. M., Wilson, K., Dang, C. V. & Cerione, A. R. Targeting mitochondrial glutaminase
activity inhibits oncogenic transformation. Cancer Cell
（2010), 18: 207-219（封面文章） IF: 27.5
* 国际肿瘤专家对此文章进行了专门评论（Preview）
Preview：Lu W, Pelicano H, Huang P. Cancer metabolism: is glutamine sweeter than glucose?
Cancer Cell. 2010 Sep 14;18(3):199-200.

14. Wang J. B., Sonn R., Yemmsrach K., Samorodnitsky T. and Osman MA. IQGAP1 regulates
cell proliferation through a novel Cdc42-mTOR pathway. Journal of Cell Science (2009),
122，2024-33 (Highlighted editorially paper).

15. Wang, J. B., Wu, W. J. & Cerione, A. R. Cdc42 and Ras cooperate to mediatedcellular
transformation by Intersectin-L. J. Biol. Chem (2005), 280, 22883-22891.

16. Feng, Q., Dan, B., Wang, J. B., Ly, T., J. L. Guan & Cerione, A. R. Cool-1 functions as an
essential regulatory node for EGF receptor- and Src- mediated cell growth. Nature Cell Biology
(2006), 8, 945-956. IF: 19.6

17. Ly T. K., Wang J. B., Pereira R., Rojas K. S., Peng X., Feng Q., Cerione A. R & Wilson K. F.
Activation of the Ran GTPase is subject to growth factor regulation and give rise to cellular
transformation. J. Biol. Chem (2010), 285, 5815-26.

18. Fidyk, N., Wang, J. B. & Cerione R. A*. Influencing cellular
transformation by modulating the rates of GTP hydrolysis by Cdc42. Biochemistry
(2006), 45, 7750-7762.

19. Tu S., Wu, W. J., Wang, J. B. & Cerione, A. R. Epidermal growth

factor-dependent regulation of Cdc42 is mediated by the Src tyrosine kinase. J.
Biol.Chem (2003), 49, 49293-49300.

20. Wang, J. B*. and Cheung, W. W. K. Multiple bacteroids in the bacteriome of the lantern bug
Pyrops candelaria Linn. (Homoptera: Fulgoridae). Parasitology Research 84, 741-745 (1998). （通讯作者）

21. Wang, J. B. & Cheung, W. W. K. Electron microscopic studies on the a-bacteroids in the fat
bodies of the lantern bug Pyrops candelaria Linn. (Homoptera: Fulgoridae). Parasitology Research
83, 499-503 (1997).

22. Cheung, W. W. K. & Wang, J. B. Electron microscopic studies on Nosema mesnili Paillot
(Microsporidia: Nosematidae) infecting the Malpighian tubules of Pieris canidia larva. Protoplasma
186, 142-148 (1995).

23. Wang, J. B. et al. Effects of thermoperiod on inducing diapause in the Ostrinia furnacalis
(Guenee) (Lepido ptera: Pyralidae). Journal of Shanxi University (Nat. Sci. Ed.) 18, 436-440
(1995).

24. Cheung, W. W. K. & Wang, J. B. Functional differentiation in the Malpighian tubules of Pieris
canidia (Lepidoptera: Pieridae) larva: A histochemical study. Annals of the Entomological Society
of America 87, 901-907 (1994).

25. Wang, J. B. & Cheung, W. W. K. Histopathological effects of Bacillus thuringiensis (α-endotoxin
on the Malpighian tubules of Pieris canidia larva. Zoological Studies 33, 192-199 (1994).

26. Cheung, W. W. K. & Wang, J. B. Ultrastructural differentiation of the Malpighian tubules of
Pieris canidia Spar. larva. Acta Biologiae Experimentalis Sinica 26, 197-213 (1993).

● 联系方式：

电话：13576981208
E-mail: jianbinwang1@gmail.com