刘琼 博士

南昌大学基础医学院讲师






● 教育和工作背景:
2010 四川农业大学动物医学专业 学士
2016 四川农业大学预防兽医学专业 博士
2014-2015 美国亚利桑那州立大学生物设计中心 联合培养
2016-至今 南昌大学基础医学院 讲师
● 研究兴趣、领域：
课题组致力于研究细菌外膜修饰机制以及细菌外膜囊泡疫苗研发。1、以沙门菌、幽门螺杆菌为研究对象，通过基因工程技术重塑细菌外膜，并基于其外膜囊泡开发新颖的外膜囊泡递呈载体，使其高效递呈外源多糖以及蛋白抗原
或者自身抗原，从而构建一系列针对不同胃肠道致病菌（霍乱弧菌、志贺菌、幽门螺杆菌等）的重组外膜囊泡疫苗用于预防和治疗细菌感染。2、以幽门螺杆菌为对象，通过对外膜进行修饰，揭示细菌外膜合成机制以及外膜囊泡
的形成机制，并基于外膜囊泡，研究细菌与宿主相互作用新机制，以期通过切断细菌与宿主互作机制来达到防治细菌病的目的，设计新颖的抗菌作用靶点和抗菌药物。近年来在以第一作者或者通讯作者在Frontiers
in Microbiology、International Journal of Medical Microbiology, Marine Drugs等学术期刊发表论文8篇,
累计影响因子超过30。
● 代表性论文：
1. Qiong Liu, Kuang Tan, Jianhui Yuan, Kuangyu Song, Rong Li, Qing Liu, Xiaotian Huang. (2018).
Flagellin-deficient outer membrane vesicles as adjuvant induce

cross-protection of Salmonella Typhimurium outer membrane proteins against infection by
heterologous Salmonella serotypes. International Journal of Medical Microbiology.

(Accepted).

2. Kuang Tan, Ruizhen Li, Xiaotian Huang, Qiong Liu#. (2018). Outer Membrane Vesicles: Current
Status and Future Direction of These Novel Vaccine Adjuvants. Frontiers in Microbiology, 9. (#
Corresponding author)
3. Qiong Liu, Jie Yi, Kang Liang, Xiangmin Zhang, Qing Liu. (2017). Salmonella Choleraesuis outer
membrane vesicles: proteomics and immunogenicity. Journal of Basic Microbiology. 57(10), 852-861.
4. Qiong Liu, Jie Yi, Kang Liang, Xiangmin Zhang, Qing Liu. (2017). Outer membrane vesicles derived
from Salmonella Enteritidis protect against the virulent wild-type strain infection in a mouse
model. Journal of Microbiology and Biotechnology. 27(8), 1519-1528.
5. Qiong Liu, Qing Liu, Jie Yi, Kang Liang, Bo Hu, Xiangmin Zhang, Roy Curtiss, Qingke Kong.
(2016). Outer membrane vesicles from flagellin-deficient Salmonella enterica serovar Typhimurium
induce cross-reactive immunity and provide
cross-protection against heterologous Salmonella challenge. Scientific Reports, 6:34776.
6. Qiong Liu, Qing Liu, Jie Yi, Kang Liang, Tian Liu, Kenneth L. Roland, Yanlong Jiang, Qingke
Kong. (2016). Outer membrane vesicles derived from Salmonella Typhimurium mutants with truncated
LPS induce cross-protective immune responses

against infection of Salmonella enterica serovars in the mouse model. International Journal of
Medical Microbiology. 306(8).
7. Qiong Liu, Qin Liu, Xinxin Zhao, Tian Liu, Kang Liang, Qingke Kong. (2016).

Immunogenicity and Cross-Protective Efficacy Induced by Outer Membrane Proteins from Salmonella
Typhimurium Mutants with Truncated LPS in Mice. International journal of molecular sciences, 17(3),
416.
8. Qiong Liu, Yanyan Li, Xinxin Zhao, Xue Yang, Qing Liu, Qingke Kong. (2015).

Construction of Escherichia coli Mutant with Decreased Endotoxic Activity by


Modifying Lipid A Structure. Marine drugs, 13(6), 3388-3406.
● 所获项目、荣誉、奖励及参加学术团体的情况：
2017 年 国家重点研发计划“Hp 感染调控胃粘膜上皮细胞改变的机制（”参加；



150 万元），
2018 年 国家自然科学基金地区项目“重组幽门螺杆菌外膜囊泡疫苗的构建与免疫保护效力评估”（40 万），主持
● 联系方式：
电话：13699555282
E-mail: p19890528@126.com
微信号：电话同号