陈胜寒 教授、博士生导师
研究方向：血管衰老
主要荣誉及专业团队任职：中国老年医学学会老年病学分
会基础
专家委员会常务理事，Bioessay编委。
邮箱：chenshenghan@ncu.edu.cn

教育经历：
1. 1986/09–1989/06， 湖北医学院， 医学， 硕士， 导师：郭树春
2. 1979/09–1984/08， 湖北医学院， 医学， 学士，

工作经历：
1. 2016/09-至今，南昌大学，生命科学学院，教授
2. 2009/03-2015/02，美国Cleveland Clinic，Lerner Research Institute, Molecular Cardiology，Research Associate
3. 2006/08-2009/02，美国Cleveland Clinic，Lerner Research Institute, Molecular Cardiology，Research Fellow
4. 2000/02-2006/07，美国Cleveland Clinic，Lerner Research Institute, Molecular Genetics，Research Fellow
5. 1997/10-2000/01，湖北医科大学，附属第一医院，副主任医师, 副教授
6. 1992/08-1997/09，湖北医科大学，附属第一医院，主治医师
7. 1989/07-1992/07，湖北医科大学，附属第一医院，住院医师
8. 1984/08-1986/08，湖北医科大学，儿科研究所，住院医师

执教课程：
本科生课程：无
研究生课程：《生命科学前沿进展》

主持课题项目：
1、2008 美国Cleveland Clinic发明奖

代表性论文：
1.Wang H, Li S, Wang J, Chen S, Sun XL, Wu Q. N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding. Elife 2018; 7. pii: e35672.
2.Li Y, Wang DW, Chen Y, Chen C, Guo J, Zhang S, Sun Z, Ding H, Yao Y, Zhou L, Xu K, Song C, Yang F, Zhao B, Yan H, Wang WJ, Wu C, Lu X, Yang X, Dong J, Zheng G, Tian S, Cui Y, Jin L, Liu G, Cui H, Wang S, Jiang F, Wang C, Erdmann J, Zeng L, Huang S, Zhong J, Ma Y, Chen W, Sun J, Lei W, Chen S, Rao S, Gu D, Schunkert H, Tian XL. Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease. Arterioscler Thromb Vasc Biol 2018; 38:964-975.
3.Song C, Yan H, Wang HM, Zhang Y, Cao H, Wan Y, Kong L, Chen S, Xu H, Pan BX, Zhang J, Fan GH, Xin HB, Liang Z, Jia W, Tian XL. AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism. J Genet Genomics 2018; 45:111-120.
4.Chen S, Wang H, Li H, Zhang Y, Wu Q. Functional analysis of corin protein domains required for PCSK6-mediated activation. Int J Biochem Cell Biol 2018; 94:31-39.
5.Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, Zhou T, Yang J, Zhang Y, Martelli1 EE, Prasad SN, Miller RE, Malfait AM, Zhou Y & Wu Q. PCSK6-mediated corin activation is essential for normal blood pressure. Nat Med 2015; 21:1048-1053.
6.Wang H, Zhou T, Peng J, Xu P, Dong N, Chen S, Wu Q. Distinct roles of N-Glycosylation at different sites of corin in cell membrane targeting and ectodomain shedding. J Biol Chem 2015; 290:1654-1663.
7.Gao H, Li L, Rao S, Shen G, Xi Q, Chen S, Zhang Z, Wang K, Ellis SG, Chen Q, Topol EJ, Wang QK. Genome-wide linkage scan identifies two novel genetic loci for coronary artery disease: In GeneQuest Families. PLoS One 2014; 9:e113935.
8.Wang W, Cui Y, Shen J, Jiang J, Chen S, Peng J, Wu Q. Salt-sensitive hypertension and cardiac hypertrophy in transgenic mice expressing a corin variant identified in blacks. Hypertension 2012; 60:1352-1358.
9.Wang W, Shen J, Cui Y, Jiang J, Chen S, Peng J, Wu Q. Impaired sodium excretion and salt-sensitive hypertension in coring-deficient mice. Kidney Int 2012; 82:26-33.
10. Cui Y, Wang W, Dong N, Lou J, Srinivasan DK, Cheng W, Huang X, Liu M, Fang C, Peng J, Chen S, Wu S, Liu Z, Dong L, Zhou Y, Wu Q. Role of corin in trophoblast invasion and uterine spiral artery remodeling in pregnancy. Nature 2012; 484:246-250.
11.Dong N, Chen S, Wang W, Zhou Y, Wu Q. Corin in clinical laboratory diagnostics. Clin Chim Acta 2012; 413:378-383.
12.Xu-Cai YO, Shen J, Chen S, Zhou Y, Larusch GA, Stavrou E, Schmaier AH, Wu Q. Factor XII gene mutation in the Hageman family. J Thromb Haemost 2011; 9:2329-2331.
13.Jiang J, Wu S, Wang W, Chen S, Peng J, Zhang X, Wu Q. Ectodomain shedding and autocleavage of the cardiac membrane protease corin. J Biol Chem 2011; 286:10066-10072.
14.Chen S, Sen S, Young D, Wang W, Moravec CS, Wu Q. Protease corin expression and activity in failing hearts. Am J Physiol Heart Circ Physiol 2010; 299:H1687-1692.
15.Dong N, Chen S*, Yang J, He L, Liu P, Zheng D, Li L, Zhou Y, Ruan C, Plow E, and Wu Q. Plasma soluble corin in patients with heart failure. Circ Heart Fail 2010; 3:207-11. (*Equal contribution as first author)
16. Wu Q, Xu-Cai YO, Chen S, and Wang W. Corin: new insights into the natriuretic peptide system. Kidney Int 2009; 5:142-146.
16. Wu Q, Xu-Cai YO, Chen S, and Wang W. Corin: new insights into the natriuretic peptide system. Kidney Int 2009; 5:142-146.
17. Zhang X, Chen S*, Yoo S, Chakrabarti S, Zhang T, Ke T, Oberti C, Yong SL, Fang F, Li L, de la Fuente R, Wang L, Chen Q, and Wang QK. Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death. Cell 2008; 135:1017-1027. (*Equal contribution as first author)
18. Zhang X, Chen S*, Zhang L, Liu M, Vincent GM, Redfearn S, Bryant RM, Oberti C, and Wang QK. Protective effect of KCNH2 single nucleotide polymorphism K897T in LQTS families and identification of novel KCNQ1 and KCNH2 mutations. BMC Med Genet 2008; 9:87. (*Equal contribution as first author)
19. Liao X, Wang W, Chen S, and Wu Q. Role of glycosylation in corin cell surface expression and zymogen activation. J Biol Chem 2007; 282(38):27728-27735.
20. Glatter KA, Wang Q, Keating M, Chen S, Chiamvimonvat N, Scheinman MM. Effective-ness of sotalol treatment in symptomatic Brugada syndrome. Am J Cardiol 2004; 93:1320-1322.
21. Chen S, Ondo WG, Rao S, Li L, Chen Q, Wang Q. Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p. Am J Hum Genet 2004; 74(5):876-885.
22. Wang Q, Chen S, Chen Q, Wan X, Shen J, Hoeltge GA, Keating MT, and Kirsch GK. Common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel. J Med Genet 2004; 41:e66 (1-7).
23. Liu M, Zhang L, Wang L, Chen S, Vincent GM, and Wang Q. Novel mutation L187P in KCNQ1 causes autosomal dominant long QT syndrome. Am J Hum Genet 2003; 73(5):405.
24. Chen S, Zhang L, Bryant RM, Vincent GM, Flippin M, Lee JC, Brown E, Zimmerman F, Rozich R, Szafranski P, Oberti C, Sterba R, Marangi D, Tchou PJ, Chung MK, and Wang Q. KCNQ1 mutations in patients with family history of lethal cardiac arrhythmias and sudden death. Clin Genet 2003; 63:273-282.
25. Fan C, Duhagon MA, Oberti C, Chen S, Hiroi Y, Komuro I, Duhagon PI, Canessa R, and Wang Q. Novel TBX5 mutations and molecular mechanism for Holt-Oram syndrome. J Med Genet 2003; 40:e29-35.
26. Chen S, Chung MK, Martin D, Rozich R, Tchou TJ, and Wang Q. SNP S1103Y in the cardiac sodium channel gene SCN5A is associated with cardiac arrhythmias and sudden death in a Caucasian family. J Med Genet 2002; 39:913-915.
27. Liu W, Yang J, Hu D, Kang C, Li C, Zhang L, Chen Z, Qin X, Ying K, Li Y, Li Y, Li Z, Cheng X, Li L, Qi Y, Chen S, and Wang Q. KCNQ1 and KCNH2 mutations associated with long QT syndrome in a Chinese population. Hum Mutat 2002; 20:475-476.
28. Wan X, Chen S, Sadeghpour A, Wang Q, et al. Accelerated inactivation in a mutant Na+ channel associated with idiopathic ventricular fibrillation. Am J Physiol Heart Circ Physiol 2001; 280(1):H354-360.