教 师 基 本 情 况

姓名：
刘良先

性别：
男

职称：
教授

学位：
博士

专业：
有机化学

E-mail：
lxliu@xmu.edu.cn

研究方向：
有机合成与绿色化学



教 育 作 经 历

1979-1982，井冈山大学化学教育专业；
1989-1992，河南师范大学化学化工学院有机化学专业，获硕士学位；
2000-2003，厦门大学化学化工学院有机化学专业，获博士学位；
2007-2008，在香港科技大学从事博士后研究工作，主要从事金属苯的设计、合成以及表征的研究。

工 作 经 历

2005年1月受聘担任厦门大学化学系副教授，现为赣南师范学院****，化学化工学院有机主任，硕士生导师。

课 程 教 学

目前承担有机化学、现代波谱学、有机合成化学、不对称合成和化学前沿讲座等本科生以及研究生课程的教学。

教 研 及 科 研 项 目

1. 基于多种合成策略的细胞毒性生物碱melodinine及相关分子的不对称合成，国家自然科学基金（**），主持。
2. 新型抗血吸虫药物的合成与筛选研究，国家自然科学基金（**）主持。
3.细胞毒性生物碱Chaetominine 及相关化合物不对称合成，国家自然科学基金(**)，主持。
4.“低碳理念”下结合地方特色的有机化学实验改革与探索，江西省教改课题（JXJG-12-11-9）。

近3年主 要 成 果

1. Copper-catalyzed direct amination of 1,2,3-triazole N-oxides via catalytic C-H, C-N
coupling. J.-Y. Zhu, Y.-B. Kong, B.-S. Wang, Z.-W. Chen, L.-X. Liu*, Eur.J.Org.Chem. 2015, 1507-1505.
2.NiSO4-catalyzedC-H activation/C-S cross-coupling of 1,2,3-triazole N-oxideswith thiols. J.-Y. Zhu, Y. Chen, F. Lin, B.-S. Wang, Z.-W. Chen, L.-X. Liu*, Org. Biomol. Chem.2015,13, 3711-3720.
3.Highly regioselective arylationof1,2,3-triazole N-oxideswith sodium arenesulfinatesviapalladium-catalyzed desulfitative cross-coupling reaction. J.-Y. Zhu, Y. Chen, F. Lin, B.-S. Wang, Q. Huang, L.-X. Liu*, Synlett, 2015, DOI: 10.1055/s-**.
4.Transition-metal-free semihydrogenationof diarylalkynes: highly stereoselective synthesis of trans-alkenes usingNa2S·9H2O. ZhengwangChen, MiaotingLuo,YueluWen,GuotianLuo,LiangxianLiu*. Org. Lett.2014, 16, 3020-3023.
5.A highly efficient synthesis of 2,5-disubstituted furans from enyne acetates catalyzed by lewis acid and palladium. ZhengwangChen, MiaotingLuo,YueluWen, Min Ye, Zhonggao Zhou,LiangxianLiu*. Synlett, 2014, 25, 2341-2344.
6.Metal-free catalyzed oxidative trimerization of indoles by using NaNO2 to construct quaternary carbon centers: the synthesis of 2-(1H-indol-3-yl)-2,3'-biindolin-3-ones.Jun Xue, Yunhong Bao, Wenbing Qin, Jiayi Zhu, Yubo Kong, Hongen Qu, Zheng-Wang Chen, Liang-Xian Liu*. Syn.Comm. 2014, 44, 2215-2221.
7.AgF/TFA-promotedhighlyefficientsynthesisof α-haloketonesfromhaloalkynes. Zheng-WangChen*,Dong-NaiYe,MinYe,Zhong-GaoZhou,Shen-HuanLi,Liang-XianLiu*.TetrahedronLett.2014, 55, 1373-1375.
8.Copper-catalyzed oxidative trimerization of indoles by using TEMPOto construct quaternary carbon centers: the synthesis of 2-(1H-indol-3-yl)-2,3'-biindolin-3-ones. Yu-Bo Kong, Jia-Yi Zhu, Liang-Xian Liu*. Can. J. Chem. 2014, 92, 269-273.
9.Metal-free (Boc)2O-mediated C4-selective direct indolationof pyridines using TEMPO. Wen-Bing Qin, Jia-Yi Zhu, Yu-Bo Kong, Yun-Hong Bao, Zheng-Wang Chen, Liang-Xian Liu*.Org. Biomol. Chem.2014,12, 4252-4259.
10.TEMPO and its derivatives: synthesis and applications. Zhonggao Zhou and Liangxian Liu*. Curr. Org. Chem.2014, 18, 459-474.
11.Highlyefficientsynthesisof2,5-disubstitutedpyrazinesfrom(Z)-β-haloenolacetates. ZhengwangChen,*DongnaiYe,GuohaiXu,MinYe, LiangxianLiu*. Org. Biomol. Chem.2013,11, 6699-6702.
12.Palladium-catalyzed oxidationof benzyl ketonesto synthesisof α-acetoxy ketones using molecular oxygen. Zheng-WangChen,* Dong-Nai Ye,MinYe,Liang-XianLiu*.Chem.Lett. 2013, 42, 1388-1390.
13.AgF/TFA-promotedhighlyefficientsynthesisof α-haloketonesfromhaloalkynes. Zheng-WangChen*,Dong-NaiYe,MinYe,Zhong-GaoZhou,Shen-HuanLi,Liang-XianLiu*.Tetrahedron Letters, 2014, 55, 1373-1375.
14.Cu(II)-catalyzed highly regio–and stereoselective constructionof C-C double bonds: an efficient methodfortheketonization-olefinationof indoles. Yun-Hong Bao, Jia-Yi Zhu, Wen-Bing Qin, Yu-Bo Kong, Zheng-Wang Chen, Shao-Bin Tang, Liang-Xian Liu*Org. Biomol. Chem.2013,11, 7938-7945.
15.HighlyefficientAgBF4-catalyzedsynthesisofmethylketonesfromterminalalkynes. Zheng-WangChen, Dong-NaiYe,Yi-PingQian,MinYe,Liang-XianLiu*. Tetrahedron, 2013, 69, 6116-6120.
16.Metal-free catalyzed oxidative trimerization of indoles by using TEMPO in air: an entry into 3-(1H-indol-3-yl)-3,3'-biindolin-2-ones. Wen-Bing Qin, Qiong Chang, Hai-Qinq Luo, Yun-Hong Bao, Zheng-Wang Chen, Liang-Xian Liu*. Curr. Org. Syn.2013, 10, 492-499.
17.Iron (Ш) trichloride-catalyzed one-pot three-component coupling of indoles and sodium nitrite:a convenient synthesis of 2,3'-bi(3H-indol)-3-one oximes. Hongen Qu, Wenbing Qin, Qiong Chang, Qiaosheng Hu, Liangxian Liu*. Curr. Org. Chem.2013, 17, 756-762.
18.Methylsulfonic acidadsorbedonsilicagelasa solid acid for dimerization of indoles: a convenient synthesis of 2,3'-bi(3H-indol)-3-one oximes. Qiong Chang, Hongen Qu, Wenbing Qin, Liangxian Liu*, Zhengwang Chen*. Syn.Comm.2013,43, 2926-2935.
19.Cu(II)-catalyzed synthesisof naphthalene-1,3-diamine derivativesfrom haloalkynesand amines. ZhengwangChen, WeiZeng, HuanfengJiang, LiangxianLiu. Org. Lett.2012, 14(21), 5385-5387.
20.Tunable dopingandbandgapofgrapheneonfunctionalizedhexagonalboronnitridewithhydrogenandfluorine. ShaobinTang, JianpingYu,LiangxianLiu, Phys.Chem.Chem.Phys., 2013,15, 5067-5077.
21.Metal-free catalyzed oxidative trimerization of indoles by using TEMPO in air: a biomimetic approach to 2-(1H-indol-3- yl)-2,3'-biindolin-3-ones. Wen-Bing Qin, Qiong Chang, Yun-Hong Bao, Ning Wang, Zheng-Wang Chen, Liang-Xian Liu*. Org. Biomol. Chem.2012,10, 8814-8821.
22.RuCl3-DCHAcatalyst system: a selective aerobic oxidation of primary benzylic alcohols under mild conditions. Kaihui Yu, Dongnai Ye, Lei Shu, Shiyong Zhang, Qiaosheng Hu, Liangxian Liu*, Syn.Comm.2012,42,2318-2326.
23.One-pot synthesisof bis(indolyl)methanes: ruthenium-catalyzed reaction of benzylic alcoholes and indoles. Shiyong Zhang, Weiyong Fan, Hongen Qu, Chen Xiao, Ning Wang, Lei Shu, Qiaosheng Hu, Liangxian Liu*Curr. Org. Chem.2012, 16, 942-948.