朱惠芳个人简历

基本信息
姓 名 ：朱惠芳 电 话：**
邮 箱：zhuhuifang1985@163.com 籍 贯：江西 南康
教育经历
2015.09-2019.01 中国科学院大学，昆明植物研究所，药理学，理学博士
2008.09-2011.06 中国科学院大学，武汉病毒研究所，生物化学与分子生物学，理学硕士
2004.09-2008.06 沈阳药科大学，生命科学与技术基地班，理学学士
科研经历
2019.01-至今 赣南医学院，第一附属医院，儿童医学中心，儿童医学研究所/新生儿科
2011.07-2012.09 中国科学院大学，昆明动物研究所，肿瘤干细胞学科组
研究方向
主要研究方向包括病毒免疫和肿瘤免疫。其中病毒免疫主要包括呼吸道合胞病毒及单纯疱疹病毒与宿主天然免疫之间的相互作用，如机体模式识别受体对病毒的免疫识别作用，以及病毒的免疫逃逸机制；肿瘤免疫主要包括基于NK细胞的儿童白血病肿瘤的免疫治疗，以及抗肿瘤天然产物的挖掘。
主持科研项目
目前主持在研项目包括国家自然科学基金项目1项，资助经费24万元；主持江西省自然科学基金项目1项，资助经费6万元；主持赣南医学院科研课题重点项目1项，资助经费5万元；主持江西省卫生健康委科技和赣州市指导性科技计划各1项。
国家自然科学基金青年基金，**，RNF26干扰STING信号通路调控肝癌细胞NKG2D配体表达的分子机制研究; 2021.01-2023.12
江西省自然科学基金，20202BAB216002，自噬和NLRP3炎症小体触发的细胞焦亡在婴幼儿RSV呼吸道感染中的作用及致病机理研究；2020.01-2022.12
赣南医学院科研课题重点项目，ZD201906，婴幼儿呼吸道合胞病毒感染的呼吸道黏膜天然免疫应答；2020.01-2021.12
发表论文
1. Huifang Zhu, Chunfu Zheng*. The race between Host Antiviral Innate Immunity and HSV-1-mediated Immune Evasion Strategies. Microbiology and Molecular Biology Reviews, 2020, 84 (4). （IF=12.568）
2. Huifang Zhu, Hongqun Liao, Xiaoming Zhong, Xingyu Rao, Xin Yang, Kaiyuan Luo*. Cleft Nucleus Lymphocytosis in Young Infants with Pertussis. Journal of Pediatric Infectious Diseases. 2020, doi.org/ 10.1055/s-.
3. Yan Ouyang, Xiaoming Zhong, Hongqun Liao, Pengcheng Zhu, Kaiyuan Luo*, Huifang Zhu*. A New Method for Screening Natural Products to Stimulate IFN-γ Production in Jurkat Human T Lymphocytes. SLAS discovery. 2020, doi.org/10.1177/22475.
4. Kaiyuan Luo, Xingyu Rao Huabin Wang, Hongqun Liao, Xiaoming Zhong, Huifang Zhu*. Natural products promote susceptibility of tumor cells to natural killer cell-mediated immune surveillance. European Journal of Immunology, 2019, 49, Suppl. 3: p1887
5. Huifang Zhu#, Bin Wang#, Lingmei Kong, Tao An, Gentao Li, Hongyu Zhou, Liang Gong, Zhangxun Zhao, Yaxiao Gong, Handong Sun, Pematenzin Puno*, Yan Li*. Parvifoline AA promotes susceptibility of hepatocarcinoma to NK cellmediated cytolysis by targeting proxiredoxin. Cell Chemical Biology, 2019, 15; 26(8):1122-1132. （IF=7.739）
6. Huifang Zhu, Fei Wang, Xiaoman Ju, Lingmei Kong, Tao An, Zhangxun Zhao, Jikai Liu*, Yan Li*. Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis. Biochemical and Biophysical Research Communications, 2018.8.23, 503: 3057~3063.
7. Huifang Zhu, Yan Li*. Small-Molecule Targets in Tumor Immunotherapy. Natural Products and Bioprospecting, 2018.7.5, 8: 297~301.
8. Huifang Zhu#, Chunfu Zheng#*, Junji Xing, Shuai Wang, Shuping Li, Rongtuan Lin, Karen L. Mossman, Varicella-Zoster Virus Immediate-Early Protein ORF61 Abrogates the IRF3-Mediated Innate Immune Response through Degradation of Activated IRF3. Journal of Virology, 2011.11, 85(21): 11079~11089.
9. Huifang Zhu, Chunfu Zheng*. Varicella zoster virus immediate early protein 61 blocks the IFN-β pathway by degradation the activited IRF3. BMC proceedings, December 2011, 5: p99.
10．朱惠芳,张远旭,赵旭东*.脑胶质瘤动物模型的建立及应用进展研究.动物学研究, 2012.6, 33(3): 337~342.
11. Huifang Zhu, Yan Li*. Natural products sensitize tumor cell to recognition and lysis by NK cell. 十二届全国天然有机化学学术会议,昆明. 2018.7.28-2018.7.31.
12. Hongyu Zhou#, Chunlei Yu#, Lingmei Kong#, Xiaoliang Xu, Juming Yan, Yingchao Li, Tao An, Liang Gong, Yaxiao Gong, Huifang Zhu, Hongbin Zhang*,Xiaodong Yang*, Yan Li*. B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells. Oncogene, 2019 May;38(18):3371-3386.
13. Tao An, Yaxiao Gong, Xue Li, Lingmei Kong, Pengcheng Ma, Liang Gong, Huifang Zhu, Chunlei Yu, Jianmei Liu, Hongyu Zhou, Bingyu Mao, Yan Li *. USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth, Biochemical Pharmacology, 2017.5, 131: 29~39.
14. Chunlei Yu, Yaxiao Gong, Hongyu Zhou, Min Wang, Lingmei Kong, Jianmei Liu, Tao An, Huifang Zhu, Yan Li*. Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model, Cell Death and Disease, 2017.2.2, 8(e2582).
15. Junji Xing#, Shuai Wang#, You Li#, Hong Guo, Lei Zhao, Weiwei Pan, Fusen Lin, Huifang Zhu, Lei Wang, Meili Li, Lin Wang, Chunfu Zheng*. Characterization of the subcellular localization of herpes simplex virus type 1 proteins in living cells, Medical Microbiology and Immunology, 2011.11.15, 200: 61~68.