Simon Wan CHAN
陳雲
PhD in Bioanalytical Chemistry
Hong Kong Baptist University, 2007

Associate Professor
Department of Chemistry
Division of Environment and Sustainability

UG Programs Coordinator (Chemistry)



(852) 2358 7370
chanwan@ust.hk
Room 4517
Personal Web

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ORCID
0000-0001-8479-3172

Scopus ID
7403917961




Research Interest Publications Projects Teaching Assignment RPG Supervision Space used




Research Interest

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Analytical chemistry
Bioanalytical chemistry
Chemical toxicology
Food chemistry
Mass spectrometry



Publications

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All Years 97 2022 0 2021 8 2020 10 2019 11 2018 5 2017 4 2016 59

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2021 8

Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid i and Balkan Endemic Nephropathy
Environmental Science and Technology, v. 55, (13), July 2021, p. 9024-9032
Guo, Wanlin; Zhang, Jiayin; Sun, Zhihan; Orem, William H.; Tatu, Calin A.; Radulovi?, Niko S.; Milovanovi?, Dragan; Pavlovi?, Nikola M.; Chan, Wan Article
Fabric Masks as a Personal Dosimeter for Quantifying Exposure to Airborne Polycyclic Aromatic Hydrocarbons
Environmental Science & Technology, v. 55, (8), April 2021, p. 5128-5135
Chan, Wan; Jin, Long; Sun, Zhihan; Griffith, Stephen M.; Yu, Jianzhen Article
Formation, Stability, and Antioxidative Properties of 2-Methylthioproline and 2-Methylthioprolineglycine in Grape Wines
ACS Food Science & Technology, v. 1, (5), May 2021, p. 892-898
Chan, Wan; Zhao, Yao; Chan, Kwan Kit Article
On the Flip Side of Mask Wearing: Increased Exposure to Volatile Organic Compounds and a Risk-Reducing Solution
Environmental Science and Technology, v. 55, (20), October 2021, p. 14095-14104
Jin, Long; Griffith, Stephen M.; Sun, Zhihan; Yu, Jianzhen; Chan, Wan Article
Polyurethane-Based Face Mask as a Sampling Device for Environmental Tobacco Smoke
Analytical Chemistry, v. 93, (41), 5 October 2021, p. 13912-13918
Chan, Wan; Guo, Wanlin; Yu, Jianzhen Article
Probing the Hidden Role of Mitochondrial DNA Damage and Dysfunction in the Etiology of Aristolochic Acid Nephropathy
Chemical Research in Toxicology, v. 24, (8), August 2021, p. 1903-1909
Chan, Wan; Ham, Yat Hing Article
Quantitation of Protein Adducts of Aristolochic Acid I by Liquid Chromatography-Tandem Mass Spectrometry: A Novel Method for Biomonitoring Aristolochic Acid Exposure
Chemical Research in Toxicology, v. 34, (1), January 2021, p. 144-153
Chan, Chi Kong; Chan, Kwan Kit; Liu, Ning; Chan, Wan Article
Quantitation of γ-Glutamylcysteine-Formaldehyde Conjugate in Formaldehyde- and Oxidative Stress-Exposed Cells by Liquid Chromatography-Tandem Mass Spectrometry
Chemical Research in Toxicology, v. 34, (7), July 2021, p. 1782-1789
Zhao, Yao; Chan, Wan Article

2020 10

Analysis of aristolochic acids in Houttuynia cordata by liquid chromatography–tandem mass spectrometry
Journal of Mass Spectrometry, 31 August 2020
Chan, Chi Kong; Pan, Guanrui; Chan, Wan Article
Determination of Aristolochic Acids in Vegetables: Nephrotoxic and Carcinogenic Environmental Pollutants Contaminating a Broad Swath of the Food Supply and Driving Incidence of Balkan Endemic Nephropathy
Chemical Research in Toxicology, v. 33, (9), 31 July 2020, p. 2446-2454
Au, Chun Kit; Zhang, Jiayin; Chan, Chi Kong; Li, Cui; Liu, Guorui; Pavlovi?, Nikola M.; Yao, Jing; Chan, Wan Article
Identifying Cysteine, N?Acetylcysteine, and Glutathione Conjugates as Novel Metabolites of Aristolochic Acid I: Emergence of a New Detoxification Pathway
Chemical Research in Toxicology, v. 33, (6), June 2020, p. 1374-1381
Zhang, Jiayin; Chan, Chi Kong; Ham, Yat Hing; Chan, Wan Article
LC-MS/MS Coupled with a Stable-Isotope Dilution Method for the Quantitation of Thioproline-Glycine: A Novel Metabolite in Formaldehyde- and Oxidative Stress-Exposed Cells
Chemical Research in Toxicology, v. 33, (7), July 2020, p. 1989-1996
Pan, Guanrui; Ham, Yat Hing; Chan, Ho Wai; Yao, Jing; Chan, Wan Article
Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy
Environmental Science and Technology, v. 54, (3), February 2020, p. 1554-1561
Tung, Ka Ki; Chan, Chi Kong; Zhao, Yao; Chan, Kwan Kit; Liu, Guorui; Pavlovic, Nikola M.; Chan, Wan Article
Proteomic Analysis of Thioproline Misincorporation in Escherichia coli
Journal of Proteomics, v. 210, January 2020, article number 103541
Liu, Jingjing; Hao, Chunlin; Wu, Long; Madej, Dominik; Chan, Wan; Lam, Hei Ning Article
Proteomics Study of DNA-Protein Crosslinks in Methylmethanesulfonate and Fe²⁺-EDTA-Exposed Human Cells
Chemical Research in Toxicology, v. 33, (11), November 2020, p. 2739-2744
Ham, Yat Hing; Chan, Kwan Kit; Madej, Dominik; Lam, Hei Ning; Chan, Wan Article
Quantitation of DNA Adducts of Aristolochic Acids in Repair-Deficient Cells: A Mechanistic Study of the DNA Repair Mechanism
Chemical Research in Toxicology, v. 33, (6), June 2020, p. 1323-1327
Au, Chun Kit; Chan, Chi Kong; Tung, Ka Ki; Zhang, Jiayin; Chan, Wan Article
Remediation of aristolochic acid-contaminated soil by an effective advanced oxidation process
Science of the Total Environment, v. 720, June 2020, article number 137528
Chan, Chi Kong; Tung, Ka Ki; Pavlovi?, Nikola M; Chan, Wan Article
Thioproline Serves as an Efficient Antioxidant Protecting Human Cells from Oxidative Stress and Improves Cell Viability
Chemical Research in Toxicology, v. 33, (7), July 2020, p. 1815-1821
Ham, Yat Hing; Chan, Kwan Kit; Chan, Wan Article

2019 11

Aristolochic acids: Newly identified exposure pathways of this class of environmental and food-borne contaminants and its potential link to chronic kidney diseases
Toxics, v. 7, (1), March 2019, article number 14
Chan, Chi Kong; Liu, Yushuo; Nikola, M.Pavlovi?; Chan, Wan Article
Development of a Novel Liquid Chromatography-Tandem Mass Spectrometric Method for Aristolochic Acids Detection: Application in Food and Agricultural Soil Analyses
Food Chemistry, v. 289, August 2019, p. 673-679
Chan, Chi Kong; Pavlovi?, Nikola M.; Chan, Wan Article
Evaluating the Performance of Sample Preparation Methods for Ultra-performance Liquid Chromatography/mass Spectrometry Based Serum Metabonomics
Rapid Communications in Mass Spectrometry, v. 33, (6), March 2019, p. 561-568
Chan, Wan; Zhao, Yao; Zhang, Jiayin Article
Gas-Phase Fragmentation Reactions of Protonated Cystine Using High-Resolution Tandem Mass Spectrometry
Molecules, v. 24, (4), February 2019, article number 747
Zhang, Pengwei; Chan, Wan; Ang, Irene L.; Wei, Rui; Lam, Melody M. T.; Lei, Kate M. K.; Poon, Terence C. W. Article
Investigation of the Chemical Structure and Formation Mechanism of Polydopamine From Self-assembly of Dopamine by Liquid Chromatography/mass Spectrometry Coupled With Isotope-labelling Techniques
Rapid Communications in Mass Spectrometry, v. 33, (5), March 2019, p. 429-436
Chan, Wan Article
Liquid chromatography–tandem mass spectrometry analysis of aristolochic acids in soil samples collected from Serbia: Link to Balkan endemic nephropathy
Rapid Communications in Mass Spectrometry, August 2019
Chan, Chi Kong; Chan, Kwan Kit; Pavlovi?, N.M.; Chan, Wan Article
Quantification of a Novel DNA–Protein Cross-Link Product Formed by Reacting Apurinic/Apyrimidinic Sites in DNA with Cysteine Residues in Protein by Liquid Chromatography-Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method
Analytical Chemistry, v. 91, (8), 16 April 2019, p. 4987-4994
Chan, Wan; Ham, Yat Hing; Jin, Long; Chan, Ho Wai; Wong, Yee Lam; Chan, Chi Kong; Chung, Pui Yin Article
Quantitation of DNA Adducts in Target and Nontarget Organs of Aristolochic Acid I-Exposed Rats: Correlating DNA Adduct Levels with Organotropic Activities
Chemical Research in Toxicology, v. 32, (3), March 2019, p. 397-399
Liu, Yushuo; Chan, Chi Kong; Jin, Long; Wong, Sum Kok; Chan, Wan Article
Quantitation of N6-Formyl-lysine Adduct Following Aristolochic Acid Exposure in Cells and Rat Tissues by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Stable Isotope-Dilution Method
Chemical Research in Toxicology, v. 32, (10), October 2019, p. 2086-2094
Zhao, Yao; Chan, Chi Kong; Chan, Kwan Kit; Chan, Wan Article
Revisiting Fragmentation Reactions of Protonated alpha-Amino Acids by High-Resolution Electrospray lonization Tandem Mass Spectrometry with Collision-Induced Dissociation
Scientific Reports, v. 9, April 2019, article number 6453
Zhang, Pengwei; Chan, Wan; Ang, Irene L.; Wei, Rui; Lam, Melody M. T.; Lei, Kate M. K.; Poon, Terence C. W. Article
Transcriptomic Responses of the Marine Cyanobacterium Prochlorococcus to Viral Lysis Products
Environmental Microbiology, v. 21, (6), June 2019, p. 2015-2028
Fang, Xiaoting; Liu, Yaxin; Zhao, Yao; Chen, Yue; Liu, Riyue; Qin, Qi-Long; Li, Gang; Zhang, Yu-Zhong; Chan, Wan; Hess, Wolfgang R.; Zeng, Qinglu Article

2018 5

Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake
Journal of Agricultural and Food Chemistry, v. 66, (43), October 2018, p. 11468-11476
Li, Weiwei; Chan, Chi Kong; Liu, Yushuo; Yao, Jing; Mitic, Branka; Kostic, Emina N.; Milosavljevic, Biljana; Davinic, Ivana; Orem, William H.; Tatu, Calin A.; Dedon, Peter C.; Pavlovic, Nikola M.; Chan, Wan Article
Cooking Methods Employing Natural Anti-oxidant Food Additives Effectively Reduced Concentration of Nephrotoxic and Carcinogenic Aristolochic Acids in Contaminated Food Grains
Food Chemistry, v 264, October 2018, p. 270-276
Li, Weiwei; Chan, Chi Kong; Wong, Yee Lam; Chan, Kwan Kit Jason; Chan, Ho Wai; Chan, Wan Article
Etiology of Balkan Endemic Nephropathy: An Update on Aristolochic Acids Exposure Mechanisms
Chemical Research in Toxicology, v. 31, (11), November 2018, p. 1109-1110
Chan, Chi Kong; Liu, Yushuo; Pavlovic, Nikola M.; Chan, Wan Article
Quantification of DNA and Protein Adducts of 1?Nitropyrene: Significantly Higher Levels of Protein than DNA Adducts in the Internal Organs of 1?Nitropyrene Exposed Rats
Chemical Research in Toxicology, v. 31, (8), Aug 2018, p. 680-687
Chan, Wan; Wong, Sum Kok; Li, Weiwei Article
Single-Turnover Kinetics Reveal a Distinct Mode of Thiamine Diphosphate-Dependent Catalysis in VitaminK Biosynthesis
ChemBioChem, v. 19, (14), July 2018, p. 1514-1522
Qin, Mingming; Song, Haigang; Dai, Xin; Chan, Chi Kong; Chan, Wan; Guo, Zhihong Article

2017 4

Determination of 2-alkylcyclobutanones in Ultraviolet Light-irradiated Fatty Acids, Triglycerides, Corn oil, and Pork Samples: Identifying a New Source of 2-alkylcyclobutanones
Food Chemistry, v. 217, February 2017, p. 352-359
Meng, Xiangpeng; Chan, Wan Article
Development of a QuEChERS-Based Method for Determination of Carcinogenic 2-Nitrofluorene and 1-Nitropyrene in Rice Grains and Vegetables: A Comparative Study with Benzo[a]pyrene
Journal of Agricultural and Food Chemistry, v. 65, (9), 8 Mar 2017, p. 1992-1999
Deng, Kailin; Chan, Simon Wan Article
Plant Uptake and Metabolism of Nitrofuran Antibiotics in Spring Onion Grown in Nitrofuran-Contaminated Soil
Journal of Agricultural and Food Chemistry, v. 65, (21), May 2017, p. 4255-4261
Wang, Yinan; Chan, Kwan Kit Jason; Chan, Wan Article
A new mode of thiamine disphosphate-dependent catalysis in vitamin K biosynthesis
International Symposium on Bioorganic Chemistry (ISBOC-11) Konstanz Symposium Chemical Biology, University of Konstanz, Konstanz, Germany, 27-29 September 2017
Song, Haigang; Qin, Mingming; Chen, Dong; Dai, Xin; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Wan; Guo, Zhihong Conference paper

2016 12

A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis
Journal of the American Chemical Society, v. 138, (23), June 2016, p. 7244-7247
Song, Haigang; Dong, Chen; Qin, Mingming; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Simon Wan; Guo, Zhihong Article
An Investigation on the Chemical Structure of Nitrogen and Sulfur?Codoped Carbon Nanoparticles by Ultra-performance Liquid Chromatography-tandem Mass Spectrometry
Analytical and Bioanalytical Chemistry, v. 408, (19), July 2016, p. 5347-5357
Hu, Qin; Meng, Xiangpeng; Chan, Simon Wan Article
Automated In-Injector Derivatization Combined with High-Performance Liquid Chromatography -Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples
Journal of Agricultural and Food Chemistry, v. 64, (13), April 2016, p. 2802-2808
Wang, Yinan; Chan, Simon Wan Article
Determination of 2-alkylcyclobutanones by Combining Precolumn Derivatization with 1-naphthalenyl hydrazine and Ultra-performance Liquid Chromatography with Fluorescence Detection
Analytical and Bioanalytical Chemistry, v. 408, (14), May 2016, p. 3707-3714
Meng, Xiangpeng; Tong, Tong; Wang, Lianrong; Liu, Hanxia; Chan, Wan Article
Determination of DNA Adducts by Combining Acid-Catalyzed Hydrolysis and Chromatographic Analysis of the Carcinogens-Modified Nucleobases
Analytical and Bioanalytical Chemistry, v. 408, (3), January 2016, p. 953-961
Leung, Elvis Ming Kit; Deng, Kailin; Wong, Tin Yan; Chan, Simon Wan Article
Elucidating the structure of carbon nanoparticles by ultra-performance liquid chromatography coupled with electrospray ionisation quadrupole time-of-flight tandem mass spectrometry
Analytica Chimica Acta, v. 911, Mar 2016, p. 100-107
Hu, Qin; Meng, Xiangpeng; Choi, Martin M.F.; Gong, Xiaojuan; Chan, Simon Wan Article
Facile Formation of a DNA Adduct of Semicarbazide on Reaction with Apurinic/Apyrimidinic Sites in DNA
Chemical research in toxicology, v. 29, (5), May 2016, p. 834-840
Wang, Yinan; Chan, Dennis H.W.; Chan, Simon Wan Article
Identification of Protein Thiazolidination as a Novel Molecular Signature for Oxidative Stress and Formaldehyde Exposure
Chemical Research in Toxicology, v. 29, (11), November 2016, p. 1865-1871
Liu, Jingjing; Chan, Kwan Kit Jason; Chan, Wan Article
Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy
Journal of Agricultural and Food Chemistry, v. 64, (29), July 2016, p. 5928-5934
Chan, Simon Wan; Pavlovi?, Nikola M.; Li, Weiwei; Chan, Chi Kong; Liu, Jingjing; Deng, Kailin; Wang, Yinan; Milosavljevic?, Biljana; Kostic?, Emina N. Article
Quantitation of the DNA Adduct of Semicarbazide in Organs of Semicarbazide-Treated Rats by Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry: A Comparative Study with the RNA Adduct
Chemical Research in Toxicology, v. 29, (9), September 2016, p. 1560-1564
Wang, Yinan; Wong, Tin Yan; Chan, Simon Wan Article
Quantitation of Thioprolines in Grape Wine by Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry
Journal of Agricultural and Food Chemistry, v. 64, (6), February 2016, p. 1361-1366
Liu, Jingjing; Meng, Xiangpeng; Chan, Wan Article
Uptake and Accumulation of Nephrotoxic and Carcinogenic Aristolochic Acids in Food Crops Grown in Aristolochia clematitis-Contaminated Soil and Water
Journal of Agricultural and Food Chemistry, 64, 1, January 2016, p. 107-112
Li, Weiwei; Hu, Qin; Chan, Simon Wan Article

2015 9

Combination of Precolumn Nitro-reduction and Ultraperformance Liquid Chromatography with Fluorescence Detection for the Sensitive Quantification of 1-Nitronaphthalene, 2-Nitrofluorene, and 1-Nitropyrene in Meat Products
Journal of Agricultural and Food Chemistry, v. 63, (12), April 2015, p. 3161-3167
Deng, Kailin; Wong, Tin Yan; Wang, Yinan; Leung, Elvis Ming Kit; Chan, Simon Wan Article
Comparison of DNA and RNA adduct formation: Significantly higher levels of RNA than DNA modifications in the internal organs of aristolochic acids-dosed rats
Chemical Research in Toxicology, v. 28, (2), February 2015, p. 248-255
Leung, Elvis Ming Kit; Chan, Simon Wan Article
Investigation of in vitro and in vivo metabolism of Schisandrin B from Schisandrae Fructus by liquid chromatography coupled electrospray ionization tandem mass spectrometry
Pharmacology & Pharmacy, v. 6, (8), August 2015, p. 363-373
Qian, Tianxiu; Leong, Pou Kuan; Ko, Kam Ming; Chan, Wan Article
Mass spectrometric and spectrofluorometric studies of the interaction of aristolochic acids with proteins
Scientific Reports, v. 5, October 2015, article number 15192
Li, Weiwei; Hu, Qin; Chan, Wan Article
Mass Spectrometric and Spectrophotometric Analyses Reveal an Alternative Structure and a New Formation Mechanism for Melanin
Analytical Chemistry, v. 87, (15), August 2015, p. 7958-7963
Li, Yuanjiao; Liu, Jingjing; Wang, Yajie; Chan, Ho Wai; Wang, Lianrong; Chan, Wan Article
Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation
Proceedings of the National Academy of Sciences of the United States of America, v. 112, (35), September 2015, p. E4845-E4853
Jumpathong, Watthanachai; Chan, Wan; Taghizadeh, Koli; Babu, I. Ramesh; Dedon, Peter C. Article
Quantification of Aristolochic Acid-RNA Adducts in the Urine of Aristolochic Acid-Treated Rats by Liquid Chromatography-Tandem Mass Spectrometry
Chemical Research in Toxicology, v. 28, (4), April 2015, p. 567-569
Leung, Elvis M.K.; Chan, Wan Article
Quantification of Thiazolidine-4-carboxylic Acid in Toxicant-Exposed Cells by Isotope-Dilution Liquid Chromatography-Mass Spectrometry Reveals an Intrinsic Antagonistic Response to Oxidative Stress-Induced Toxicity
Chemical Research in Toxicology, v. 28, (3), March 2015, p. 394-400
Liu, Jingjing; Chan, Wan Article
Regulation of DNA phosphorothioate modification in Salmonella enterica by DndB
Scientific Reports, v. 5, July 2015, article number 12368
He, Wei; Huang, Teng; Tang, You; Liu, Yanhua; Wu, Xiaolin; Chen, Si; Chan, Wan; Wang, Yajie; Liu, Xiaoyun; Chen, Shi; Wang, Lianrong Article

2014 4

A novel reversed-phase HPLC method for the determination of urinary creatinine by pre-column derivatization with ethyl chloroformate: comparative studies with the standard Jaffé , and isotope-dilution mass spectrometric assays
Analytical and Bioanalytical Chemistry, v. 406, (6), 2014, p. 1807-1812
Leung, Elvis Ming Kit; Chan, Wan Article
Determination of Aristolochic Acids by High-Performance Liquid Chromatography with Fluorescence Detection
Journal of Agricultural and Food Chemistry, v. 62, (25), June 2014, p. 5859-5864
Wang, Yinan; Chan, Wan Article
Noninvasive measurement of aristolochic acid-DNA adducts in urine samples from aristolochic acid-treated rats by liquid chromatography coupled tandem mass spectrometry: Evidence for DNA repair by nucleotide-excision repair mechanisms
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, v. 766, August 2014, p. 1-6
Leung, Elvis Ming Kit; Chan, Simon Wan Article
Rapid identification of gamma-irradiated food by direct solvent extraction and liquid chromatography-tandem mass spectrometric analysis of 2-dodecylcyclobutanone: Application in surveillance of irradiated food
Food Chemistry, v. 161, October 2014, p. 312-316
Chan, Simon Wan; Ye, Yuran; Leung, Elvis Ming Kit Article

2013 6

Analysis of 2-Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2-Alkylcyclobutanones for Irradiated Food Identification
Journal of Agricultural and Food Chemistry, v. 61, (41), October 2013, p. 9950-9954
Leung, Elvis Ming Kit; Tang, Phyllis Nya Yang; Ye, Yuran; Chan, Wan Article
Capillary electrophoretic study of amine/carboxylic acid-functionalized carbon nanodots
Journal of Chromatography A, v. 1304, August 2013, p. 234-240
Hu, Qin; Paau, Man Chin; Zhang, Yan; Chan, Wan; Gong, Xiaojuan; Zhang, Lei; Choi, Martin M.F. Article
Combination of pentafluorophenylhydrazine derivatization and isotope dilution LC-MS/MS techniques for the quantification of apurinic/apyrimidinic sites in cellular DNA
Analytical and Bioanalytical Chemistry, v. 405, (12), 2013, p. 4059-4066
Li, Jie; Leung, Elvis Ming Kit; Choi, Martin Ming Fat; Chan, Wan Article
Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry
Journal of Pharmaceutical and Biomedical Analysis, v. 74, February 2013, p. 156-161
Li, Jie; Chan, Wan Article
Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometric Analysis of 2-Alkylcyclobutanones in Irradiated Chicken by Precolumn Derivatization with Hydroxylamine
Journal of Agricultural and Food Chemistry, v. 61, (24), June 2013, p. 5758-5763
Ye, Yuran; Liu, Hanxia; Horvatovich, Peter; Chan, Wan Article
Probing Histidine-Stabilized Gold Nanoclusters Product by High-Performance Liquid Chromatography and Mass Spectrometry
Journal of Physical Chemistry C, v. 117, (36), September 2013, p. 18697-18708
Zhang, Yan; Hu, Qin; Paau, Man Chin; Xie, Shunping; Gao, Pengfei; Chan, Wan; Choi, Martin Ming Fat Article

2012 2

High-performance liquid chromatographic analysis of as-synthesised N,N '-dimethylformamide-stabilised gold nanoclusters product
Nanoscale, v. 4, (17), 2012, p. 5325-5332
Xie, Shunping; Paau, Man Chin; Zhang, Yan; Shuang, Shaomin; Chan, Wan; Choi, Martin M.F. Article
In situ analysis of 8-Oxo-7,8-dihydro-2′-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra
Journal of the American Chemical Society, v. 134, (43), 2012, p. 18053-18064
Lim, K.S.; Cui, L.; Taghizadeh, K.; Wishnok, J.S.; Chan, Wan; Demott, M.S.; Babu, I.R.; Tannenbaum, S.R.; Dedon, P.C. Article

2011 2

DNA phosphorothioation is widespread and quantized in bacterial genomes
Proceedings of the National Academy of Sciences of the United States of America, v. 108, (7), 2011, p. 2963-2968
Wang, Lianrong; Chen, Shi; Vergin, Kevin, L.; Giovannoni, Stephen J.; Chan, Simon Wan; Demott, Michael S.; Taghizadeh, Koli; Cordero, Otto X.; Cutler, Michael; Timberlake, Sonia; Alm, Eric J.; Polz, Martin F.; Pinhassi, Jarone; Deng, Zixin; Dedon, Peter C. Article
Metabolomics Analysis of the Responses to Partial Hepatectomy in Hepatocellular Carcinoma Patients
American Journal of Analytical Chemistry, v. 2, 2011, p. 142-151
Chan, Wan; Lin, Shuhai; Sun, Stella; Liu, Hongde; Cai, Zongwei; Luk, John M. Article

2010 3

Liquid chromatography/mass spectrometry for investigating the biochemical effects induced by aristolochic acid in rats: the plasma metabolome
Rapid Communications in Mass Spectrometry, v. 24, (9), 2010, p. 1312-1318
Lin, Shuhai; Chan, Wan; Li, Jinhua; Cai, Zongwei Article
Quantification of the 2-Deoxyribonolactone and Nucleoside 5′-Aldehyde Products of 2-Deoxyribose Oxidation in DNA and Cells by Isotope-Dilution Gas Chromatography Mass Spectrometry: Differential Effects of γ-Radiation and Fe²⁺?EDTA
Journal of the American Chemical Society, v. 132, (17), 2010, p. 6145-6153
Chan, Wan; Chen, Bingzi; Wang, Lianrong; Taghizadeh, Koli; Demott, Michael S.; Dedon, Peter C. Article
The biological and metabolic fates of endogenous DNA damage products
Journal of Nucleic Acids, v. 2010, 2010, article number 929047
Chan, Simon Wan; Dedon, Peter C. Article

2009 5

A Method to Enhance a 1 Ions and Application for Peptide Sequencing and Protein Identification
Journal of the American Society for Mass Spectrometry, v. 20, (6), 2009, p. 1214-1223
Liu, N.; Chan, Wan; Lee, K.C.; Cai, Z. Article
A new approach for the sensitive determination of DNA adduct of aristolochic acid II by using high-performance liquid chromatography with fluorescence detection
Journal of chromatography. B, v. 877, (10), 2009, p. 848-852
Chan, Wan; Poon, W.T.; Chan, Y.W.; Wan, K.Y.; Cai, Z. Article
Determination of aristolochic acid I in rat urine and plasma by high-performance liquid chromatography with fluorescence detection
Journal of chromatography. B, v. 877, (10), 2009, p. 995-999
Yue, H.; Chan, Wan; Guo, L.; Cai, Z. Article
On-line capillary electrophoresis-electrospray ionization mass spectrometry analysis of urinary porphyrins
Electrophoresis, v. 30, 2009, p. 1790-1797
Li, JH; Chan, Wan; Cai, ZW Article
Recent progress in quantitative analysis of DNA adducts of nephrotoxin aristolochic acid
Science in China. Series B, Chemistry, v. 52, (10), 2009, p. 1576-1582
Yue, H.; Chan, Wan; Yu, K.; Guo, L.; Liu, N.; Liu, H.; Cai, Z. Article

2008 8

Aristolochic acid induced changes in the metabolic profile of rat urine
Journal of pharmaceutical and biomedical analysis, v. 46, (4), 2008, p. 757-762
Chan, Wan; Cai, Z. Article
Characterization of the DNA adducts induced by aristolochic acids in oligonucleotides by electrospray ionization tandem mass spectrometry
Rapid communications in mass spectrometry, v. 22, (23), 2008, p. 3735-3742
Chan, Wan; Yue, H.; Wong, R.N.S.; Cai, Z. Article
High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen
Talanta, v. 75, (4), 2008, p. 1002-1007
Cui, L.; Chan, Wan; Wu, J.L.; Jiang, Z.H.; Chan, K.; Cai, Z. Article
Identification of four urea adducts of Andrographolide in human
Drug Metab. Lett., v. 2, 2008, p. 261-268
Cui, L.; Chan, Wan; Qiu, F.; Cai, ZW; Yao, Z. Article
Liquid chromatography/mass spectrometry for metabonomics investigation of the biochemical effects induced by aristolochic acid in rats: The use of information-dependent acquisition for biomarker identification
Rapid communications in mass spectrometry, v. 22, (6), 2008, p. 873-880
Chan, Wan; Lee, K.C.; Liu, N.; Wong, R.N.S.; Liu, H.; Cai, Z. Article
Proteomics analysis of differential expression of cellular proteins in response to avian H9N2 virus infection in human cells
Proteomics, v. 8, 2008, p. 1851-1858
Liu, N.; Song, WJ; Wang, P.; Lee, KC; Chan, Wan; Chen, HL; Cai, ZW Article
Quantification of Aristolochic Acid-Derived DNA Adducts in Rat Kidney and Liver by Using Liquid Chromatography-Electrospray Ionization Mass Spectrometry
Mutat. Res, v. 646, 2008, p. 17-24
Chan, Wan; Yue, H.; Poon, WY; Chan,Y-W; Schmitz, Oliver J.; Kwong, Daniel WJ; Wong, Ricky NS; Cai, ZW Article
Rapid screening method for intact glucosinolates in Chinese medicinal herbs by using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry in negative ion mode
Rapid communications in mass spectrometry, v. 22, (18), 2008, p. 2825-2834
Lee, K.C.; Chan, Wan; Liang, Z.; Liu, N.; Zhao, Z.; Lee, A.W.M.; Cai, Z. Article

2007 4

A sensitivity enhanced high-performance liquid chromatography fluorescence method for the detection of nephrotoxic and carcinogenic aristolochic acid in herbal medicines
Journal of chromatography. A, v. 1164, (1-2), 2007, p. 113-119
Chan, Wan; Lee, K.C.; Liu, N.; Cai, ZW Article
Investigation of the metabolism and reductive activation of carcinogenic aristolochic acids in rats
Drug Metab. Dispos, v. 35, 2007, p. 866-874
Chan, Wan; Luo, HB; Zheng, YF; Cheng, YK; Cai, ZW Article
Liquid Chromatography-Tandem Mass Spectrometry Analysis of the DNA Adducts of Aristolochic Acids
Journal of the American Society for Mass Spectrometry, v. 18, (4), 2007, p. 642-650
Chan, Wan; Zheng, Y.; Cai, Z. Article
Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry
Analytical and bioanalytical chemistry, v. 387, (6), 2007, p. 2219-2225
Ma, W.T.; Chan, Wan; Steinbach, K.; Cai, Z. Conference paper

2006 3

Determination of glucosinolates in traditional Chinese herbs by high-performance liquid chromatography and electrospray ionization mass spectrometry
Analytical and bioanalytical chemistry, v. 386, (7-8), 2006, p. 2225-2232
Lee, K.C.; Cheuk, M.W.; Chan, Wan; Lee, A.W.M.; Zhao, Z.Z.; Jiang, Z.H.; Cai, Z. Article
Differentiation of herbs linked to "Chinese herb nephropathy" from the liquid chromatographic determination of aristolochic acids
Analytica Chimica Acta, v. 576, (1), 2006, p. 112-116
Chan, Wan; Hui, K.M.; Poon, W.T.; Lee, K.C.; Cai, Z. Article
Study of the phase I and phase II metabolism of nephrotoxin aristolochic acid by liquid chromatography/tandem mass spectrometry
Rapid communications in mass spectrometry, v. 20, (11), 2006, p. 1755-1760
Chan, Wan; Cui, L.; Xu, G.; Cai, Z. Article

2005 1

Identification of components in traditional Chinese medicinal products using LC-MS
Encyclopedia of Mass Spectrometry (V8), Pergamon Pr, 2005, article number: Else_EMASV008_93
Chan, Wan; Cai, ZW Article


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Article 8

Analysis of Polycyclic Aromatic Hydrocarbons and Phthalate Esters in Soil and Food Grains from the Balkan Peninsula: Implication on DNA Adduct Formation by Aristolochic Acid i and Balkan Endemic Nephropathy
Environmental Science and Technology, v. 55, (13), July 2021, p. 9024-9032
Guo, Wanlin; Zhang, Jiayin; Sun, Zhihan; Orem, William H.; Tatu, Calin A.; Radulovi?, Niko S.; Milovanovi?, Dragan; Pavlovi?, Nikola M.; Chan, Wan
Fabric Masks as a Personal Dosimeter for Quantifying Exposure to Airborne Polycyclic Aromatic Hydrocarbons
Environmental Science & Technology, v. 55, (8), April 2021, p. 5128-5135
Chan, Wan; Jin, Long; Sun, Zhihan; Griffith, Stephen M.; Yu, Jianzhen
Formation, Stability, and Antioxidative Properties of 2-Methylthioproline and 2-Methylthioprolineglycine in Grape Wines
ACS Food Science & Technology, v. 1, (5), May 2021, p. 892-898
Chan, Wan; Zhao, Yao; Chan, Kwan Kit
On the Flip Side of Mask Wearing: Increased Exposure to Volatile Organic Compounds and a Risk-Reducing Solution
Environmental Science and Technology, v. 55, (20), October 2021, p. 14095-14104
Jin, Long; Griffith, Stephen M.; Sun, Zhihan; Yu, Jianzhen; Chan, Wan
Polyurethane-Based Face Mask as a Sampling Device for Environmental Tobacco Smoke
Analytical Chemistry, v. 93, (41), 5 October 2021, p. 13912-13918
Chan, Wan; Guo, Wanlin; Yu, Jianzhen
Probing the Hidden Role of Mitochondrial DNA Damage and Dysfunction in the Etiology of Aristolochic Acid Nephropathy
Chemical Research in Toxicology, v. 24, (8), August 2021, p. 1903-1909
Chan, Wan; Ham, Yat Hing
Quantitation of Protein Adducts of Aristolochic Acid I by Liquid Chromatography-Tandem Mass Spectrometry: A Novel Method for Biomonitoring Aristolochic Acid Exposure
Chemical Research in Toxicology, v. 34, (1), January 2021, p. 144-153
Chan, Chi Kong; Chan, Kwan Kit; Liu, Ning; Chan, Wan
Quantitation of γ-Glutamylcysteine-Formaldehyde Conjugate in Formaldehyde- and Oxidative Stress-Exposed Cells by Liquid Chromatography-Tandem Mass Spectrometry
Chemical Research in Toxicology, v. 34, (7), July 2021, p. 1782-1789
Zhao, Yao; Chan, Wan


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Article 10

Analysis of aristolochic acids in Houttuynia cordata by liquid chromatography–tandem mass spectrometry
Journal of Mass Spectrometry, 31 August 2020
Chan, Chi Kong; Pan, Guanrui; Chan, Wan
Determination of Aristolochic Acids in Vegetables: Nephrotoxic and Carcinogenic Environmental Pollutants Contaminating a Broad Swath of the Food Supply and Driving Incidence of Balkan Endemic Nephropathy
Chemical Research in Toxicology, v. 33, (9), 31 July 2020, p. 2446-2454
Au, Chun Kit; Zhang, Jiayin; Chan, Chi Kong; Li, Cui; Liu, Guorui; Pavlovi?, Nikola M.; Yao, Jing; Chan, Wan
Identifying Cysteine, N?Acetylcysteine, and Glutathione Conjugates as Novel Metabolites of Aristolochic Acid I: Emergence of a New Detoxification Pathway
Chemical Research in Toxicology, v. 33, (6), June 2020, p. 1374-1381
Zhang, Jiayin; Chan, Chi Kong; Ham, Yat Hing; Chan, Wan
LC-MS/MS Coupled with a Stable-Isotope Dilution Method for the Quantitation of Thioproline-Glycine: A Novel Metabolite in Formaldehyde- and Oxidative Stress-Exposed Cells
Chemical Research in Toxicology, v. 33, (7), July 2020, p. 1989-1996
Pan, Guanrui; Ham, Yat Hing; Chan, Ho Wai; Yao, Jing; Chan, Wan
Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy
Environmental Science and Technology, v. 54, (3), February 2020, p. 1554-1561
Tung, Ka Ki; Chan, Chi Kong; Zhao, Yao; Chan, Kwan Kit; Liu, Guorui; Pavlovic, Nikola M.; Chan, Wan
Proteomic Analysis of Thioproline Misincorporation in Escherichia coli
Journal of Proteomics, v. 210, January 2020, article number 103541
Liu, Jingjing; Hao, Chunlin; Wu, Long; Madej, Dominik; Chan, Wan; Lam, Hei Ning
Proteomics Study of DNA-Protein Crosslinks in Methylmethanesulfonate and Fe²⁺-EDTA-Exposed Human Cells
Chemical Research in Toxicology, v. 33, (11), November 2020, p. 2739-2744
Ham, Yat Hing; Chan, Kwan Kit; Madej, Dominik; Lam, Hei Ning; Chan, Wan
Quantitation of DNA Adducts of Aristolochic Acids in Repair-Deficient Cells: A Mechanistic Study of the DNA Repair Mechanism
Chemical Research in Toxicology, v. 33, (6), June 2020, p. 1323-1327
Au, Chun Kit; Chan, Chi Kong; Tung, Ka Ki; Zhang, Jiayin; Chan, Wan
Remediation of aristolochic acid-contaminated soil by an effective advanced oxidation process
Science of the Total Environment, v. 720, June 2020, article number 137528
Chan, Chi Kong; Tung, Ka Ki; Pavlovi?, Nikola M; Chan, Wan
Thioproline Serves as an Efficient Antioxidant Protecting Human Cells from Oxidative Stress and Improves Cell Viability
Chemical Research in Toxicology, v. 33, (7), July 2020, p. 1815-1821
Ham, Yat Hing; Chan, Kwan Kit; Chan, Wan


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Article 11

Aristolochic acids: Newly identified exposure pathways of this class of environmental and food-borne contaminants and its potential link to chronic kidney diseases
Toxics, v. 7, (1), March 2019, article number 14
Chan, Chi Kong; Liu, Yushuo; Nikola, M.Pavlovi?; Chan, Wan
Development of a Novel Liquid Chromatography-Tandem Mass Spectrometric Method for Aristolochic Acids Detection: Application in Food and Agricultural Soil Analyses
Food Chemistry, v. 289, August 2019, p. 673-679
Chan, Chi Kong; Pavlovi?, Nikola M.; Chan, Wan
Evaluating the Performance of Sample Preparation Methods for Ultra-performance Liquid Chromatography/mass Spectrometry Based Serum Metabonomics
Rapid Communications in Mass Spectrometry, v. 33, (6), March 2019, p. 561-568
Chan, Wan; Zhao, Yao; Zhang, Jiayin
Gas-Phase Fragmentation Reactions of Protonated Cystine Using High-Resolution Tandem Mass Spectrometry
Molecules, v. 24, (4), February 2019, article number 747
Zhang, Pengwei; Chan, Wan; Ang, Irene L.; Wei, Rui; Lam, Melody M. T.; Lei, Kate M. K.; Poon, Terence C. W.
Investigation of the Chemical Structure and Formation Mechanism of Polydopamine From Self-assembly of Dopamine by Liquid Chromatography/mass Spectrometry Coupled With Isotope-labelling Techniques
Rapid Communications in Mass Spectrometry, v. 33, (5), March 2019, p. 429-436
Chan, Wan
Liquid chromatography–tandem mass spectrometry analysis of aristolochic acids in soil samples collected from Serbia: Link to Balkan endemic nephropathy
Rapid Communications in Mass Spectrometry, August 2019
Chan, Chi Kong; Chan, Kwan Kit; Pavlovi?, N.M.; Chan, Wan
Quantification of a Novel DNA–Protein Cross-Link Product Formed by Reacting Apurinic/Apyrimidinic Sites in DNA with Cysteine Residues in Protein by Liquid Chromatography-Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method
Analytical Chemistry, v. 91, (8), 16 April 2019, p. 4987-4994
Chan, Wan; Ham, Yat Hing; Jin, Long; Chan, Ho Wai; Wong, Yee Lam; Chan, Chi Kong; Chung, Pui Yin
Quantitation of DNA Adducts in Target and Nontarget Organs of Aristolochic Acid I-Exposed Rats: Correlating DNA Adduct Levels with Organotropic Activities
Chemical Research in Toxicology, v. 32, (3), March 2019, p. 397-399
Liu, Yushuo; Chan, Chi Kong; Jin, Long; Wong, Sum Kok; Chan, Wan
Quantitation of N6-Formyl-lysine Adduct Following Aristolochic Acid Exposure in Cells and Rat Tissues by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Stable Isotope-Dilution Method
Chemical Research in Toxicology, v. 32, (10), October 2019, p. 2086-2094
Zhao, Yao; Chan, Chi Kong; Chan, Kwan Kit; Chan, Wan
Revisiting Fragmentation Reactions of Protonated alpha-Amino Acids by High-Resolution Electrospray lonization Tandem Mass Spectrometry with Collision-Induced Dissociation
Scientific Reports, v. 9, April 2019, article number 6453
Zhang, Pengwei; Chan, Wan; Ang, Irene L.; Wei, Rui; Lam, Melody M. T.; Lei, Kate M. K.; Poon, Terence C. W.
Transcriptomic Responses of the Marine Cyanobacterium Prochlorococcus to Viral Lysis Products
Environmental Microbiology, v. 21, (6), June 2019, p. 2015-2028
Fang, Xiaoting; Liu, Yaxin; Zhao, Yao; Chen, Yue; Liu, Riyue; Qin, Qi-Long; Li, Gang; Zhang, Yu-Zhong; Chan, Wan; Hess, Wolfgang R.; Zeng, Qinglu


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Article 5

Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake
Journal of Agricultural and Food Chemistry, v. 66, (43), October 2018, p. 11468-11476
Li, Weiwei; Chan, Chi Kong; Liu, Yushuo; Yao, Jing; Mitic, Branka; Kostic, Emina N.; Milosavljevic, Biljana; Davinic, Ivana; Orem, William H.; Tatu, Calin A.; Dedon, Peter C.; Pavlovic, Nikola M.; Chan, Wan
Cooking Methods Employing Natural Anti-oxidant Food Additives Effectively Reduced Concentration of Nephrotoxic and Carcinogenic Aristolochic Acids in Contaminated Food Grains
Food Chemistry, v 264, October 2018, p. 270-276
Li, Weiwei; Chan, Chi Kong; Wong, Yee Lam; Chan, Kwan Kit Jason; Chan, Ho Wai; Chan, Wan
Etiology of Balkan Endemic Nephropathy: An Update on Aristolochic Acids Exposure Mechanisms
Chemical Research in Toxicology, v. 31, (11), November 2018, p. 1109-1110
Chan, Chi Kong; Liu, Yushuo; Pavlovic, Nikola M.; Chan, Wan
Quantification of DNA and Protein Adducts of 1?Nitropyrene: Significantly Higher Levels of Protein than DNA Adducts in the Internal Organs of 1?Nitropyrene Exposed Rats
Chemical Research in Toxicology, v. 31, (8), Aug 2018, p. 680-687
Chan, Wan; Wong, Sum Kok; Li, Weiwei
Single-Turnover Kinetics Reveal a Distinct Mode of Thiamine Diphosphate-Dependent Catalysis in VitaminK Biosynthesis
ChemBioChem, v. 19, (14), July 2018, p. 1514-1522
Qin, Mingming; Song, Haigang; Dai, Xin; Chan, Chi Kong; Chan, Wan; Guo, Zhihong


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Article 3

Determination of 2-alkylcyclobutanones in Ultraviolet Light-irradiated Fatty Acids, Triglycerides, Corn oil, and Pork Samples: Identifying a New Source of 2-alkylcyclobutanones
Food Chemistry, v. 217, February 2017, p. 352-359
Meng, Xiangpeng; Chan, Wan
Development of a QuEChERS-Based Method for Determination of Carcinogenic 2-Nitrofluorene and 1-Nitropyrene in Rice Grains and Vegetables: A Comparative Study with Benzo[a]pyrene
Journal of Agricultural and Food Chemistry, v. 65, (9), 8 Mar 2017, p. 1992-1999
Deng, Kailin; Chan, Simon Wan
Plant Uptake and Metabolism of Nitrofuran Antibiotics in Spring Onion Grown in Nitrofuran-Contaminated Soil
Journal of Agricultural and Food Chemistry, v. 65, (21), May 2017, p. 4255-4261
Wang, Yinan; Chan, Kwan Kit Jason; Chan, Wan

Conference paper 1

A new mode of thiamine disphosphate-dependent catalysis in vitamin K biosynthesis
International Symposium on Bioorganic Chemistry (ISBOC-11) Konstanz Symposium Chemical Biology, University of Konstanz, Konstanz, Germany, 27-29 September 2017
Song, Haigang; Qin, Mingming; Chen, Dong; Dai, Xin; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Wan; Guo, Zhihong


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Article 12

A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis
Journal of the American Chemical Society, v. 138, (23), June 2016, p. 7244-7247
Song, Haigang; Dong, Chen; Qin, Mingming; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Simon Wan; Guo, Zhihong
An Investigation on the Chemical Structure of Nitrogen and Sulfur?Codoped Carbon Nanoparticles by Ultra-performance Liquid Chromatography-tandem Mass Spectrometry
Analytical and Bioanalytical Chemistry, v. 408, (19), July 2016, p. 5347-5357
Hu, Qin; Meng, Xiangpeng; Chan, Simon Wan
Automated In-Injector Derivatization Combined with High-Performance Liquid Chromatography -Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples
Journal of Agricultural and Food Chemistry, v. 64, (13), April 2016, p. 2802-2808
Wang, Yinan; Chan, Simon Wan
Determination of 2-alkylcyclobutanones by Combining Precolumn Derivatization with 1-naphthalenyl hydrazine and Ultra-performance Liquid Chromatography with Fluorescence Detection
Analytical and Bioanalytical Chemistry, v. 408, (14), May 2016, p. 3707-3714
Meng, Xiangpeng; Tong, Tong; Wang, Lianrong; Liu, Hanxia; Chan, Wan
Determination of DNA Adducts by Combining Acid-Catalyzed Hydrolysis and Chromatographic Analysis of the Carcinogens-Modified Nucleobases
Analytical and Bioanalytical Chemistry, v. 408, (3), January 2016, p. 953-961
Leung, Elvis Ming Kit; Deng, Kailin; Wong, Tin Yan; Chan, Simon Wan
Elucidating the structure of carbon nanoparticles by ultra-performance liquid chromatography coupled with electrospray ionisation quadrupole time-of-flight tandem mass spectrometry
Analytica Chimica Acta, v. 911, Mar 2016, p. 100-107
Hu, Qin; Meng, Xiangpeng; Choi, Martin M.F.; Gong, Xiaojuan; Chan, Simon Wan
Facile Formation of a DNA Adduct of Semicarbazide on Reaction with Apurinic/Apyrimidinic Sites in DNA
Chemical research in toxicology, v. 29, (5), May 2016, p. 834-840
Wang, Yinan; Chan, Dennis H.W.; Chan, Simon Wan
Identification of Protein Thiazolidination as a Novel Molecular Signature for Oxidative Stress and Formaldehyde Exposure
Chemical Research in Toxicology, v. 29, (11), November 2016, p. 1865-1871
Liu, Jingjing; Chan, Kwan Kit Jason; Chan, Wan
Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy
Journal of Agricultural and Food Chemistry, v. 64, (29), July 2016, p. 5928-5934
Chan, Simon Wan; Pavlovi?, Nikola M.; Li, Weiwei; Chan, Chi Kong; Liu, Jingjing; Deng, Kailin; Wang, Yinan; Milosavljevic?, Biljana; Kostic?, Emina N.
Quantitation of the DNA Adduct of Semicarbazide in Organs of Semicarbazide-Treated Rats by Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry: A Comparative Study with the RNA Adduct
Chemical Research in Toxicology, v. 29, (9), September 2016, p. 1560-1564
Wang, Yinan; Wong, Tin Yan; Chan, Simon Wan
Quantitation of Thioprolines in Grape Wine by Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry
Journal of Agricultural and Food Chemistry, v. 64, (6), February 2016, p. 1361-1366
Liu, Jingjing; Meng, Xiangpeng; Chan, Wan
Uptake and Accumulation of Nephrotoxic and Carcinogenic Aristolochic Acids in Food Crops Grown in Aristolochia clematitis-Contaminated Soil and Water
Journal of Agricultural and Food Chemistry, 64, 1, January 2016, p. 107-112
Li, Weiwei; Hu, Qin; Chan, Simon Wan


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Article 9

Combination of Precolumn Nitro-reduction and Ultraperformance Liquid Chromatography with Fluorescence Detection for the Sensitive Quantification of 1-Nitronaphthalene, 2-Nitrofluorene, and 1-Nitropyrene in Meat Products
Journal of Agricultural and Food Chemistry, v. 63, (12), April 2015, p. 3161-3167
Deng, Kailin; Wong, Tin Yan; Wang, Yinan; Leung, Elvis Ming Kit; Chan, Simon Wan
Comparison of DNA and RNA adduct formation: Significantly higher levels of RNA than DNA modifications in the internal organs of aristolochic acids-dosed rats
Chemical Research in Toxicology, v. 28, (2), February 2015, p. 248-255
Leung, Elvis Ming Kit; Chan, Simon Wan
Investigation of in vitro and in vivo metabolism of Schisandrin B from Schisandrae Fructus by liquid chromatography coupled electrospray ionization tandem mass spectrometry
Pharmacology & Pharmacy, v. 6, (8), August 2015, p. 363-373
Qian, Tianxiu; Leong, Pou Kuan; Ko, Kam Ming; Chan, Wan
Mass spectrometric and spectrofluorometric studies of the interaction of aristolochic acids with proteins
Scientific Reports, v. 5, October 2015, article number 15192
Li, Weiwei; Hu, Qin; Chan, Wan
Mass Spectrometric and Spectrophotometric Analyses Reveal an Alternative Structure and a New Formation Mechanism for Melanin
Analytical Chemistry, v. 87, (15), August 2015, p. 7958-7963
Li, Yuanjiao; Liu, Jingjing; Wang, Yajie; Chan, Ho Wai; Wang, Lianrong; Chan, Wan
Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation
Proceedings of the National Academy of Sciences of the United States of America, v. 112, (35), September 2015, p. E4845-E4853
Jumpathong, Watthanachai; Chan, Wan; Taghizadeh, Koli; Babu, I. Ramesh; Dedon, Peter C.
Quantification of Aristolochic Acid-RNA Adducts in the Urine of Aristolochic Acid-Treated Rats by Liquid Chromatography-Tandem Mass Spectrometry
Chemical Research in Toxicology, v. 28, (4), April 2015, p. 567-569
Leung, Elvis M.K.; Chan, Wan
Quantification of Thiazolidine-4-carboxylic Acid in Toxicant-Exposed Cells by Isotope-Dilution Liquid Chromatography-Mass Spectrometry Reveals an Intrinsic Antagonistic Response to Oxidative Stress-Induced Toxicity
Chemical Research in Toxicology, v. 28, (3), March 2015, p. 394-400
Liu, Jingjing; Chan, Wan
Regulation of DNA phosphorothioate modification in Salmonella enterica by DndB
Scientific Reports, v. 5, July 2015, article number 12368
He, Wei; Huang, Teng; Tang, You; Liu, Yanhua; Wu, Xiaolin; Chen, Si; Chan, Wan; Wang, Yajie; Liu, Xiaoyun; Chen, Shi; Wang, Lianrong


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Article 4

A novel reversed-phase HPLC method for the determination of urinary creatinine by pre-column derivatization with ethyl chloroformate: comparative studies with the standard Jaffé , and isotope-dilution mass spectrometric assays
Analytical and Bioanalytical Chemistry, v. 406, (6), 2014, p. 1807-1812
Leung, Elvis Ming Kit; Chan, Wan
Determination of Aristolochic Acids by High-Performance Liquid Chromatography with Fluorescence Detection
Journal of Agricultural and Food Chemistry, v. 62, (25), June 2014, p. 5859-5864
Wang, Yinan; Chan, Wan
Noninvasive measurement of aristolochic acid-DNA adducts in urine samples from aristolochic acid-treated rats by liquid chromatography coupled tandem mass spectrometry: Evidence for DNA repair by nucleotide-excision repair mechanisms
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, v. 766, August 2014, p. 1-6
Leung, Elvis Ming Kit; Chan, Simon Wan
Rapid identification of gamma-irradiated food by direct solvent extraction and liquid chromatography-tandem mass spectrometric analysis of 2-dodecylcyclobutanone: Application in surveillance of irradiated food
Food Chemistry, v. 161, October 2014, p. 312-316
Chan, Simon Wan; Ye, Yuran; Leung, Elvis Ming Kit


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Article 6

Analysis of 2-Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2-Alkylcyclobutanones for Irradiated Food Identification
Journal of Agricultural and Food Chemistry, v. 61, (41), October 2013, p. 9950-9954
Leung, Elvis Ming Kit; Tang, Phyllis Nya Yang; Ye, Yuran; Chan, Wan
Capillary electrophoretic study of amine/carboxylic acid-functionalized carbon nanodots
Journal of Chromatography A, v. 1304, August 2013, p. 234-240
Hu, Qin; Paau, Man Chin; Zhang, Yan; Chan, Wan; Gong, Xiaojuan; Zhang, Lei; Choi, Martin M.F.
Combination of pentafluorophenylhydrazine derivatization and isotope dilution LC-MS/MS techniques for the quantification of apurinic/apyrimidinic sites in cellular DNA
Analytical and Bioanalytical Chemistry, v. 405, (12), 2013, p. 4059-4066
Li, Jie; Leung, Elvis Ming Kit; Choi, Martin Ming Fat; Chan, Wan
Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry
Journal of Pharmaceutical and Biomedical Analysis, v. 74, February 2013, p. 156-161
Li, Jie; Chan, Wan
Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometric Analysis of 2-Alkylcyclobutanones in Irradiated Chicken by Precolumn Derivatization with Hydroxylamine
Journal of Agricultural and Food Chemistry, v. 61, (24), June 2013, p. 5758-5763
Ye, Yuran; Liu, Hanxia; Horvatovich, Peter; Chan, Wan
Probing Histidine-Stabilized Gold Nanoclusters Product by High-Performance Liquid Chromatography and Mass Spectrometry
Journal of Physical Chemistry C, v. 117, (36), September 2013, p. 18697-18708
Zhang, Yan; Hu, Qin; Paau, Man Chin; Xie, Shunping; Gao, Pengfei; Chan, Wan; Choi, Martin Ming Fat


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Article 2

High-performance liquid chromatographic analysis of as-synthesised N,N '-dimethylformamide-stabilised gold nanoclusters product
Nanoscale, v. 4, (17), 2012, p. 5325-5332
Xie, Shunping; Paau, Man Chin; Zhang, Yan; Shuang, Shaomin; Chan, Wan; Choi, Martin M.F.
In situ analysis of 8-Oxo-7,8-dihydro-2′-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra
Journal of the American Chemical Society, v. 134, (43), 2012, p. 18053-18064
Lim, K.S.; Cui, L.; Taghizadeh, K.; Wishnok, J.S.; Chan, Wan; Demott, M.S.; Babu, I.R.; Tannenbaum, S.R.; Dedon, P.C.


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Article 2

DNA phosphorothioation is widespread and quantized in bacterial genomes
Proceedings of the National Academy of Sciences of the United States of America, v. 108, (7), 2011, p. 2963-2968
Wang, Lianrong; Chen, Shi; Vergin, Kevin, L.; Giovannoni, Stephen J.; Chan, Simon Wan; Demott, Michael S.; Taghizadeh, Koli; Cordero, Otto X.; Cutler, Michael; Timberlake, Sonia; Alm, Eric J.; Polz, Martin F.; Pinhassi, Jarone; Deng, Zixin; Dedon, Peter C.
Metabolomics Analysis of the Responses to Partial Hepatectomy in Hepatocellular Carcinoma Patients
American Journal of Analytical Chemistry, v. 2, 2011, p. 142-151
Chan, Wan; Lin, Shuhai; Sun, Stella; Liu, Hongde; Cai, Zongwei; Luk, John M.


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Article 3

Liquid chromatography/mass spectrometry for investigating the biochemical effects induced by aristolochic acid in rats: the plasma metabolome
Rapid Communications in Mass Spectrometry, v. 24, (9), 2010, p. 1312-1318
Lin, Shuhai; Chan, Wan; Li, Jinhua; Cai, Zongwei
Quantification of the 2-Deoxyribonolactone and Nucleoside 5′-Aldehyde Products of 2-Deoxyribose Oxidation in DNA and Cells by Isotope-Dilution Gas Chromatography Mass Spectrometry: Differential Effects of γ-Radiation and Fe²⁺?EDTA
Journal of the American Chemical Society, v. 132, (17), 2010, p. 6145-6153
Chan, Wan; Chen, Bingzi; Wang, Lianrong; Taghizadeh, Koli; Demott, Michael S.; Dedon, Peter C.
The biological and metabolic fates of endogenous DNA damage products
Journal of Nucleic Acids, v. 2010, 2010, article number 929047
Chan, Simon Wan; Dedon, Peter C.


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Article 5

A Method to Enhance a 1 Ions and Application for Peptide Sequencing and Protein Identification
Journal of the American Society for Mass Spectrometry, v. 20, (6), 2009, p. 1214-1223
Liu, N.; Chan, Wan; Lee, K.C.; Cai, Z.
A new approach for the sensitive determination of DNA adduct of aristolochic acid II by using high-performance liquid chromatography with fluorescence detection
Journal of chromatography. B, v. 877, (10), 2009, p. 848-852
Chan, Wan; Poon, W.T.; Chan, Y.W.; Wan, K.Y.; Cai, Z.
Determination of aristolochic acid I in rat urine and plasma by high-performance liquid chromatography with fluorescence detection
Journal of chromatography. B, v. 877, (10), 2009, p. 995-999
Yue, H.; Chan, Wan; Guo, L.; Cai, Z.
On-line capillary electrophoresis-electrospray ionization mass spectrometry analysis of urinary porphyrins
Electrophoresis, v. 30, 2009, p. 1790-1797
Li, JH; Chan, Wan; Cai, ZW
Recent progress in quantitative analysis of DNA adducts of nephrotoxin aristolochic acid
Science in China. Series B, Chemistry, v. 52, (10), 2009, p. 1576-1582
Yue, H.; Chan, Wan; Yu, K.; Guo, L.; Liu, N.; Liu, H.; Cai, Z.


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Article 8

Aristolochic acid induced changes in the metabolic profile of rat urine
Journal of pharmaceutical and biomedical analysis, v. 46, (4), 2008, p. 757-762
Chan, Wan; Cai, Z.
Characterization of the DNA adducts induced by aristolochic acids in oligonucleotides by electrospray ionization tandem mass spectrometry
Rapid communications in mass spectrometry, v. 22, (23), 2008, p. 3735-3742
Chan, Wan; Yue, H.; Wong, R.N.S.; Cai, Z.
High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen
Talanta, v. 75, (4), 2008, p. 1002-1007
Cui, L.; Chan, Wan; Wu, J.L.; Jiang, Z.H.; Chan, K.; Cai, Z.
Identification of four urea adducts of Andrographolide in human
Drug Metab. Lett., v. 2, 2008, p. 261-268
Cui, L.; Chan, Wan; Qiu, F.; Cai, ZW; Yao, Z.
Liquid chromatography/mass spectrometry for metabonomics investigation of the biochemical effects induced by aristolochic acid in rats: The use of information-dependent acquisition for biomarker identification
Rapid communications in mass spectrometry, v. 22, (6), 2008, p. 873-880
Chan, Wan; Lee, K.C.; Liu, N.; Wong, R.N.S.; Liu, H.; Cai, Z.
Proteomics analysis of differential expression of cellular proteins in response to avian H9N2 virus infection in human cells
Proteomics, v. 8, 2008, p. 1851-1858
Liu, N.; Song, WJ; Wang, P.; Lee, KC; Chan, Wan; Chen, HL; Cai, ZW
Quantification of Aristolochic Acid-Derived DNA Adducts in Rat Kidney and Liver by Using Liquid Chromatography-Electrospray Ionization Mass Spectrometry
Mutat. Res, v. 646, 2008, p. 17-24
Chan, Wan; Yue, H.; Poon, WY; Chan,Y-W; Schmitz, Oliver J.; Kwong, Daniel WJ; Wong, Ricky NS; Cai, ZW
Rapid screening method for intact glucosinolates in Chinese medicinal herbs by using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry in negative ion mode
Rapid communications in mass spectrometry, v. 22, (18), 2008, p. 2825-2834
Lee, K.C.; Chan, Wan; Liang, Z.; Liu, N.; Zhao, Z.; Lee, A.W.M.; Cai, Z.


Expand All Collapse All


Article 3

A sensitivity enhanced high-performance liquid chromatography fluorescence method for the detection of nephrotoxic and carcinogenic aristolochic acid in herbal medicines
Journal of chromatography. A, v. 1164, (1-2), 2007, p. 113-119
Chan, Wan; Lee, K.C.; Liu, N.; Cai, ZW
Investigation of the metabolism and reductive activation of carcinogenic aristolochic acids in rats
Drug Metab. Dispos, v. 35, 2007, p. 866-874
Chan, Wan; Luo, HB; Zheng, YF; Cheng, YK; Cai, ZW
Liquid Chromatography-Tandem Mass Spectrometry Analysis of the DNA Adducts of Aristolochic Acids
Journal of the American Society for Mass Spectrometry, v. 18, (4), 2007, p. 642-650
Chan, Wan; Zheng, Y.; Cai, Z.

Conference paper 1

Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry
Analytical and bioanalytical chemistry, v. 387, (6), 2007, p. 2219-2225
Ma, W.T.; Chan, Wan; Steinbach, K.; Cai, Z.


Expand All Collapse All


Article 3

Determination of glucosinolates in traditional Chinese herbs by high-performance liquid chromatography and electrospray ionization mass spectrometry
Analytical and bioanalytical chemistry, v. 386, (7-8), 2006, p. 2225-2232
Lee, K.C.; Cheuk, M.W.; Chan, Wan; Lee, A.W.M.; Zhao, Z.Z.; Jiang, Z.H.; Cai, Z.
Differentiation of herbs linked to "Chinese herb nephropathy" from the liquid chromatographic determination of aristolochic acids
Analytica Chimica Acta, v. 576, (1), 2006, p. 112-116
Chan, Wan; Hui, K.M.; Poon, W.T.; Lee, K.C.; Cai, Z.
Study of the phase I and phase II metabolism of nephrotoxin aristolochic acid by liquid chromatography/tandem mass spectrometry
Rapid communications in mass spectrometry, v. 20, (11), 2006, p. 1755-1760
Chan, Wan; Cui, L.; Xu, G.; Cai, Z.


Expand All Collapse All


Article 1

Identification of components in traditional Chinese medicinal products using LC-MS
Encyclopedia of Mass Spectrometry (V8), Pergamon Pr, 2005, article number: Else_EMASV008_93
Chan, Wan; Cai, ZW


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2016 12

A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis
Journal of the American Chemical Society, v. 138, (23), June 2016, p. 7244-7247
Song, Haigang; Dong, Chen; Qin, Mingming; Chen, Yaozong; Sun, Yueru; Liu, Jingjing; Chan, Simon Wan; Guo, Zhihong Article
An Investigation on the Chemical Structure of Nitrogen and Sulfur?Codoped Carbon Nanoparticles by Ultra-performance Liquid Chromatography-tandem Mass Spectrometry
Analytical and Bioanalytical Chemistry, v. 408, (19), July 2016, p. 5347-5357
Hu, Qin; Meng, Xiangpeng; Chan, Simon Wan Article
Automated In-Injector Derivatization Combined with High-Performance Liquid Chromatography -Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples
Journal of Agricultural and Food Chemistry, v. 64, (13), April 2016, p. 2802-2808
Wang, Yinan; Chan, Simon Wan Article
Determination of 2-alkylcyclobutanones by Combining Precolumn Derivatization with 1-naphthalenyl hydrazine and Ultra-performance Liquid Chromatography with Fluorescence Detection
Analytical and Bioanalytical Chemistry, v. 408, (14), May 2016, p. 3707-3714
Meng, Xiangpeng; Tong, Tong; Wang, Lianrong; Liu, Hanxia; Chan, Wan Article
Determination of DNA Adducts by Combining Acid-Catalyzed Hydrolysis and Chromatographic Analysis of the Carcinogens-Modified Nucleobases
Analytical and Bioanalytical Chemistry, v. 408, (3), January 2016, p. 953-961
Leung, Elvis Ming Kit; Deng, Kailin; Wong, Tin Yan; Chan, Simon Wan Article
Elucidating the structure of carbon nanoparticles by ultra-performance liquid chromatography coupled with electrospray ionisation quadrupole time-of-flight tandem mass spectrometry
Analytica Chimica Acta, v. 911, Mar 2016, p. 100-107
Hu, Qin; Meng, Xiangpeng; Choi, Martin M.F.; Gong, Xiaojuan; Chan, Simon Wan Article
Facile Formation of a DNA Adduct of Semicarbazide on Reaction with Apurinic/Apyrimidinic Sites in DNA
Chemical research in toxicology, v. 29, (5), May 2016, p. 834-840
Wang, Yinan; Chan, Dennis H.W.; Chan, Simon Wan Article
Identification of Protein Thiazolidination as a Novel Molecular Signature for Oxidative Stress and Formaldehyde Exposure
Chemical Research in Toxicology, v. 29, (11), November 2016, p. 1865-1871
Liu, Jingjing; Chan, Kwan Kit Jason; Chan, Wan Article
Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy
Journal of Agricultural and Food Chemistry, v. 64, (29), July 2016, p. 5928-5934
Chan, Simon Wan; Pavlovi?, Nikola M.; Li, Weiwei; Chan, Chi Kong; Liu, Jingjing; Deng, Kailin; Wang, Yinan; Milosavljevic?, Biljana; Kostic?, Emina N. Article
Quantitation of the DNA Adduct of Semicarbazide in Organs of Semicarbazide-Treated Rats by Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry: A Comparative Study with the RNA Adduct
Chemical Research in Toxicology, v. 29, (9), September 2016, p. 1560-1564
Wang, Yinan; Wong, Tin Yan; Chan, Simon Wan Article
Quantitation of Thioprolines in Grape Wine by Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry
Journal of Agricultural and Food Chemistry, v. 64, (6), February 2016, p. 1361-1366
Liu, Jingjing; Meng, Xiangpeng; Chan, Wan Article
Uptake and Accumulation of Nephrotoxic and Carcinogenic Aristolochic Acids in Food Crops Grown in Aristolochia clematitis-Contaminated Soil and Water
Journal of Agricultural and Food Chemistry, 64, 1, January 2016, p. 107-112
Li, Weiwei; Hu, Qin; Chan, Simon Wan Article

2015 9

Combination of Precolumn Nitro-reduction and Ultraperformance Liquid Chromatography with Fluorescence Detection for the Sensitive Quantification of 1-Nitronaphthalene, 2-Nitrofluorene, and 1-Nitropyrene in Meat Products
Journal of Agricultural and Food Chemistry, v. 63, (12), April 2015, p. 3161-3167
Deng, Kailin; Wong, Tin Yan; Wang, Yinan; Leung, Elvis Ming Kit; Chan, Simon Wan Article
Comparison of DNA and RNA adduct formation: Significantly higher levels of RNA than DNA modifications in the internal organs of aristolochic acids-dosed rats
Chemical Research in Toxicology, v. 28, (2), February 2015, p. 248-255
Leung, Elvis Ming Kit; Chan, Simon Wan Article
Investigation of in vitro and in vivo metabolism of Schisandrin B from Schisandrae Fructus by liquid chromatography coupled electrospray ionization tandem mass spectrometry
Pharmacology & Pharmacy, v. 6, (8), August 2015, p. 363-373
Qian, Tianxiu; Leong, Pou Kuan; Ko, Kam Ming; Chan, Wan Article
Mass spectrometric and spectrofluorometric studies of the interaction of aristolochic acids with proteins
Scientific Reports, v. 5, October 2015, article number 15192
Li, Weiwei; Hu, Qin; Chan, Wan Article
Mass Spectrometric and Spectrophotometric Analyses Reveal an Alternative Structure and a New Formation Mechanism for Melanin
Analytical Chemistry, v. 87, (15), August 2015, p. 7958-7963
Li, Yuanjiao; Liu, Jingjing; Wang, Yajie; Chan, Ho Wai; Wang, Lianrong; Chan, Wan Article
Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation
Proceedings of the National Academy of Sciences of the United States of America, v. 112, (35), September 2015, p. E4845-E4853
Jumpathong, Watthanachai; Chan, Wan; Taghizadeh, Koli; Babu, I. Ramesh; Dedon, Peter C. Article
Quantification of Aristolochic Acid-RNA Adducts in the Urine of Aristolochic Acid-Treated Rats by Liquid Chromatography-Tandem Mass Spectrometry
Chemical Research in Toxicology, v. 28, (4), April 2015, p. 567-569
Leung, Elvis M.K.; Chan, Wan Article
Quantification of Thiazolidine-4-carboxylic Acid in Toxicant-Exposed Cells by Isotope-Dilution Liquid Chromatography-Mass Spectrometry Reveals an Intrinsic Antagonistic Response to Oxidative Stress-Induced Toxicity
Chemical Research in Toxicology, v. 28, (3), March 2015, p. 394-400
Liu, Jingjing; Chan, Wan Article
Regulation of DNA phosphorothioate modification in Salmonella enterica by DndB
Scientific Reports, v. 5, July 2015, article number 12368
He, Wei; Huang, Teng; Tang, You; Liu, Yanhua; Wu, Xiaolin; Chen, Si; Chan, Wan; Wang, Yajie; Liu, Xiaoyun; Chen, Shi; Wang, Lianrong Article

2014 4

A novel reversed-phase HPLC method for the determination of urinary creatinine by pre-column derivatization with ethyl chloroformate: comparative studies with the standard Jaffé , and isotope-dilution mass spectrometric assays
Analytical and Bioanalytical Chemistry, v. 406, (6), 2014, p. 1807-1812
Leung, Elvis Ming Kit; Chan, Wan Article
Determination of Aristolochic Acids by High-Performance Liquid Chromatography with Fluorescence Detection
Journal of Agricultural and Food Chemistry, v. 62, (25), June 2014, p. 5859-5864
Wang, Yinan; Chan, Wan Article
Noninvasive measurement of aristolochic acid-DNA adducts in urine samples from aristolochic acid-treated rats by liquid chromatography coupled tandem mass spectrometry: Evidence for DNA repair by nucleotide-excision repair mechanisms
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, v. 766, August 2014, p. 1-6
Leung, Elvis Ming Kit; Chan, Simon Wan Article
Rapid identification of gamma-irradiated food by direct solvent extraction and liquid chromatography-tandem mass spectrometric analysis of 2-dodecylcyclobutanone: Application in surveillance of irradiated food
Food Chemistry, v. 161, October 2014, p. 312-316
Chan, Simon Wan; Ye, Yuran; Leung, Elvis Ming Kit Article

2013 6

Analysis of 2-Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2-Alkylcyclobutanones for Irradiated Food Identification
Journal of Agricultural and Food Chemistry, v. 61, (41), October 2013, p. 9950-9954
Leung, Elvis Ming Kit; Tang, Phyllis Nya Yang; Ye, Yuran; Chan, Wan Article
Capillary electrophoretic study of amine/carboxylic acid-functionalized carbon nanodots
Journal of Chromatography A, v. 1304, August 2013, p. 234-240
Hu, Qin; Paau, Man Chin; Zhang, Yan; Chan, Wan; Gong, Xiaojuan; Zhang, Lei; Choi, Martin M.F. Article
Combination of pentafluorophenylhydrazine derivatization and isotope dilution LC-MS/MS techniques for the quantification of apurinic/apyrimidinic sites in cellular DNA
Analytical and Bioanalytical Chemistry, v. 405, (12), 2013, p. 4059-4066
Li, Jie; Leung, Elvis Ming Kit; Choi, Martin Ming Fat; Chan, Wan Article
Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry
Journal of Pharmaceutical and Biomedical Analysis, v. 74, February 2013, p. 156-161
Li, Jie; Chan, Wan Article
Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometric Analysis of 2-Alkylcyclobutanones in Irradiated Chicken by Precolumn Derivatization with Hydroxylamine
Journal of Agricultural and Food Chemistry, v. 61, (24), June 2013, p. 5758-5763
Ye, Yuran; Liu, Hanxia; Horvatovich, Peter; Chan, Wan Article
Probing Histidine-Stabilized Gold Nanoclusters Product by High-Performance Liquid Chromatography and Mass Spectrometry
Journal of Physical Chemistry C, v. 117, (36), September 2013, p. 18697-18708
Zhang, Yan; Hu, Qin; Paau, Man Chin; Xie, Shunping; Gao, Pengfei; Chan, Wan; Choi, Martin Ming Fat Article

2012 2

High-performance liquid chromatographic analysis of as-synthesised N,N '-dimethylformamide-stabilised gold nanoclusters product
Nanoscale, v. 4, (17), 2012, p. 5325-5332
Xie, Shunping; Paau, Man Chin; Zhang, Yan; Shuang, Shaomin; Chan, Wan; Choi, Martin M.F. Article
In situ analysis of 8-Oxo-7,8-dihydro-2′-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra
Journal of the American Chemical Society, v. 134, (43), 2012, p. 18053-18064
Lim, K.S.; Cui, L.; Taghizadeh, K.; Wishnok, J.S.; Chan, Wan; Demott, M.S.; Babu, I.R.; Tannenbaum, S.R.; Dedon, P.C. Article

2011 2

DNA phosphorothioation is widespread and quantized in bacterial genomes
Proceedings of the National Academy of Sciences of the United States of America, v. 108, (7), 2011, p. 2963-2968
Wang, Lianrong; Chen, Shi; Vergin, Kevin, L.; Giovannoni, Stephen J.; Chan, Simon Wan; Demott, Michael S.; Taghizadeh, Koli; Cordero, Otto X.; Cutler, Michael; Timberlake, Sonia; Alm, Eric J.; Polz, Martin F.; Pinhassi, Jarone; Deng, Zixin; Dedon, Peter C. Article
Metabolomics Analysis of the Responses to Partial Hepatectomy in Hepatocellular Carcinoma Patients
American Journal of Analytical Chemistry, v. 2, 2011, p. 142-151
Chan, Wan; Lin, Shuhai; Sun, Stella; Liu, Hongde; Cai, Zongwei; Luk, John M. Article

2010 3

Liquid chromatography/mass spectrometry for investigating the biochemical effects induced by aristolochic acid in rats: the plasma metabolome
Rapid Communications in Mass Spectrometry, v. 24, (9), 2010, p. 1312-1318
Lin, Shuhai; Chan, Wan; Li, Jinhua; Cai, Zongwei Article
Quantification of the 2-Deoxyribonolactone and Nucleoside 5′-Aldehyde Products of 2-Deoxyribose Oxidation in DNA and Cells by Isotope-Dilution Gas Chromatography Mass Spectrometry: Differential Effects of γ-Radiation and Fe²⁺?EDTA
Journal of the American Chemical Society, v. 132, (17), 2010, p. 6145-6153
Chan, Wan; Chen, Bingzi; Wang, Lianrong; Taghizadeh, Koli; Demott, Michael S.; Dedon, Peter C. Article
The biological and metabolic fates of endogenous DNA damage products
Journal of Nucleic Acids, v. 2010, 2010, article number 929047
Chan, Simon Wan; Dedon, Peter C. Article

2009 5

A Method to Enhance a 1 Ions and Application for Peptide Sequencing and Protein Identification
Journal of the American Society for Mass Spectrometry, v. 20, (6), 2009, p. 1214-1223
Liu, N.; Chan, Wan; Lee, K.C.; Cai, Z. Article
A new approach for the sensitive determination of DNA adduct of aristolochic acid II by using high-performance liquid chromatography with fluorescence detection
Journal of chromatography. B, v. 877, (10), 2009, p. 848-852
Chan, Wan; Poon, W.T.; Chan, Y.W.; Wan, K.Y.; Cai, Z. Article
Determination of aristolochic acid I in rat urine and plasma by high-performance liquid chromatography with fluorescence detection
Journal of chromatography. B, v. 877, (10), 2009, p. 995-999
Yue, H.; Chan, Wan; Guo, L.; Cai, Z. Article
On-line capillary electrophoresis-electrospray ionization mass spectrometry analysis of urinary porphyrins
Electrophoresis, v. 30, 2009, p. 1790-1797
Li, JH; Chan, Wan; Cai, ZW Article
Recent progress in quantitative analysis of DNA adducts of nephrotoxin aristolochic acid
Science in China. Series B, Chemistry, v. 52, (10), 2009, p. 1576-1582
Yue, H.; Chan, Wan; Yu, K.; Guo, L.; Liu, N.; Liu, H.; Cai, Z. Article

2008 8

Aristolochic acid induced changes in the metabolic profile of rat urine
Journal of pharmaceutical and biomedical analysis, v. 46, (4), 2008, p. 757-762
Chan, Wan; Cai, Z. Article
Characterization of the DNA adducts induced by aristolochic acids in oligonucleotides by electrospray ionization tandem mass spectrometry
Rapid communications in mass spectrometry, v. 22, (23), 2008, p. 3735-3742
Chan, Wan; Yue, H.; Wong, R.N.S.; Cai, Z. Article
High performance liquid chromatography-mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen
Talanta, v. 75, (4), 2008, p. 1002-1007
Cui, L.; Chan, Wan; Wu, J.L.; Jiang, Z.H.; Chan, K.; Cai, Z. Article
Identification of four urea adducts of Andrographolide in human
Drug Metab. Lett., v. 2, 2008, p. 261-268
Cui, L.; Chan, Wan; Qiu, F.; Cai, ZW; Yao, Z. Article
Liquid chromatography/mass spectrometry for metabonomics investigation of the biochemical effects induced by aristolochic acid in rats: The use of information-dependent acquisition for biomarker identification
Rapid communications in mass spectrometry, v. 22, (6), 2008, p. 873-880
Chan, Wan; Lee, K.C.; Liu, N.; Wong, R.N.S.; Liu, H.; Cai, Z. Article
Proteomics analysis of differential expression of cellular proteins in response to avian H9N2 virus infection in human cells
Proteomics, v. 8, 2008, p. 1851-1858
Liu, N.; Song, WJ; Wang, P.; Lee, KC; Chan, Wan; Chen, HL; Cai, ZW Article
Quantification of Aristolochic Acid-Derived DNA Adducts in Rat Kidney and Liver by Using Liquid Chromatography-Electrospray Ionization Mass Spectrometry
Mutat. Res, v. 646, 2008, p. 17-24
Chan, Wan; Yue, H.; Poon, WY; Chan,Y-W; Schmitz, Oliver J.; Kwong, Daniel WJ; Wong, Ricky NS; Cai, ZW Article
Rapid screening method for intact glucosinolates in Chinese medicinal herbs by using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry in negative ion mode
Rapid communications in mass spectrometry, v. 22, (18), 2008, p. 2825-2834
Lee, K.C.; Chan, Wan; Liang, Z.; Liu, N.; Zhao, Z.; Lee, A.W.M.; Cai, Z. Article

2007 4

A sensitivity enhanced high-performance liquid chromatography fluorescence method for the detection of nephrotoxic and carcinogenic aristolochic acid in herbal medicines
Journal of chromatography. A, v. 1164, (1-2), 2007, p. 113-119
Chan, Wan; Lee, K.C.; Liu, N.; Cai, ZW Article
Investigation of the metabolism and reductive activation of carcinogenic aristolochic acids in rats
Drug Metab. Dispos, v. 35, 2007, p. 866-874
Chan, Wan; Luo, HB; Zheng, YF; Cheng, YK; Cai, ZW Article
Liquid Chromatography-Tandem Mass Spectrometry Analysis of the DNA Adducts of Aristolochic Acids
Journal of the American Society for Mass Spectrometry, v. 18, (4), 2007, p. 642-650
Chan, Wan; Zheng, Y.; Cai, Z. Article
Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry
Analytical and bioanalytical chemistry, v. 387, (6), 2007, p. 2219-2225
Ma, W.T.; Chan, Wan; Steinbach, K.; Cai, Z. Conference paper

2006 3

Determination of glucosinolates in traditional Chinese herbs by high-performance liquid chromatography and electrospray ionization mass spectrometry
Analytical and bioanalytical chemistry, v. 386, (7-8), 2006, p. 2225-2232
Lee, K.C.; Cheuk, M.W.; Chan, Wan; Lee, A.W.M.; Zhao, Z.Z.; Jiang, Z.H.; Cai, Z. Article
Differentiation of herbs linked to "Chinese herb nephropathy" from the liquid chromatographic determination of aristolochic acids
Analytica Chimica Acta, v. 576, (1), 2006, p. 112-116
Chan, Wan; Hui, K.M.; Poon, W.T.; Lee, K.C.; Cai, Z. Article
Study of the phase I and phase II metabolism of nephrotoxin aristolochic acid by liquid chromatography/tandem mass spectrometry
Rapid communications in mass spectrometry, v. 20, (11), 2006, p. 1755-1760
Chan, Wan; Cui, L.; Xu, G.; Cai, Z. Article

2005 1

Identification of components in traditional Chinese medicinal products using LC-MS
Encyclopedia of Mass Spectrometry (V8), Pergamon Pr, 2005, article number: Else_EMASV008_93
Chan, Wan; Cai, ZW Article


No Publications






Teaching Assignment

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2021-22 Winter 0 2021-22 Fall 2 2020-21 Summer 1 2020-21 Spring 5 2020-21 Winter 0 2020-21 Fall 3

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CHEM2310 Fundamentals of Analytical Chemistry
CHEM4691 Capstone Research I


CHEM4691 Capstone Research I


CHEM2311 Analytical Chemistry
CHEM4689 Capstone Project
CHEM4692 Capstone Research II
CHMS5112 Food and Drug Analysis
SCIE1500 Guided Study on Research I


CHEM2310 Fundamentals of Analytical Chemistry
CHEM4691 Capstone Research I
CHMS5040 Separation Methods


No Teaching Assignments


No Teaching Assignments






Research Postgraduate (RPG) Supervision From January 2019 to December 2022 (As of 01 February 2022)

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All Supervisions Current RPGs Graduated RPGs

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Current RPGs

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Doctor of Philosophy GUO, Wanlin
Chemistry( 2021 - )

YUAN, Chenrui
Chemistry( 2021 - )

HAM, Yat Hing
Chemistry( 2020 - )

KWOK, Hong Ching
Chemistry( 2020 - )

TUNG, Ka Ki
Chemistry( 2020 - )

CHIN, Man Lung
Chemistry( 2019 - )

JIN, Long
Chemistry( 2019 - )

PAN, Guanrui
Chemistry( 2019 - )

AU, Chun Kit
Chemistry( 2018 - )

CHAN, Chi Kong
Chemistry( 2018 - )

ZHANG, Jiayin
Chemistry( 2018 - )

ZHAO, Yao
Chemistry( 2017 - )

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Master of Philosophy NG, Ka Ki
Chemistry( 2021 - )

TSE, Hei Tak
Chemistry( 2021 - )

SUN, Zhihan
Chemistry( 2020 - )

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Graduated RPGs

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Master of Philosophy CHUNG, Pui Yin
Atmospheric Environmental Science( Completed in 2019 )

LIU, Yushuo
Atmospheric Environmental Science( Completed in 2019 )

WONG, Sum Kok
Atmospheric Environmental Science( Completed in 2019 )









ProjectsFrom January 2020 to December 2022

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All Projects 10 Leading Projects 8 Participating Projects 2

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Chemical Approaches to Investigate the Potential Health Effects of 2-Chlorobenzalmalononitrile and to Develop a Biomarker of Exposure


以化學方法研究2-氯苯亞甲基丙二腈的潛在健康影響並開發其暴露的生物標誌物 Leading


RGC - General Research Fund


Project Team (HKUST)
CHAN Simon Wan (Lead)


2022 -




Liquid chromatography-coupled mass spectrometry-based adductomics to discovery etiological agents and biomarkers of leukemia in human


液相色譜-串聯質譜法加合物組學用于發現人類白血病病原物及生物標志物 Leading


RGC - General Research Fund


Project Team (HKUST)
CHAN Simon Wan (Lead)


2021 -




Survey of Environmental Pollution from Aristolochic Acids in Herbal Medicine Cultivation areas of Mainland China Leading


The TUYF Charitable Trust


Project Team (HKUST)
CHAN Simon Wan (Lead)
TSIM Karl Wah Keung


2021 -




Developing Protein Adducts as Clinically Useful Biomarkers for Identifying Kidney Diseases Caused by Aristolochic Acids Exposure Using Mass Spectrometry-Based Analytical Methods


使用基于質譜分析方法開發蛋白加合物作為臨床上識別馬兜鈴酸導致的腎病的生物標志物 Leading


RGC - General Research Fund


Project Team (HKUST)
CHAN Simon Wan (Lead)


2020 -




Research & Development of Traditional Chinese Medicine Classics formula——Data Platform Establishing


經典名方作用機理、物質基準和二次開發研究——數據平臺的建立 Participating


Nanhai People's Government of Foshan


Project Team (HKUST)
TSIM Karl Wah Keung (Lead)
CHAN Simon Wan
LAM Henry Hei Ning
WANG Yang


2020 -




Chemical Approach to Investigate the Molecular Mechanism of Aristolochic Acids-Induced Nephropathy


用化學方法研究馬兜鈴酸誘發的腎病的分子機制 Leading


RGC - General Research Fund


Project Team (HKUST)
CHAN Simon Wan (Lead)


2019 - 2021




Recognition of the role of aristolochic acids poisoning in chronic kidney disease observed in China


闡明馬兜鈴酸中毒在中國慢性腎臟疾病中扮演的角色 Participating


The TUYF Charitable Trust


Project Team (HKUST)
CHAN Simon Wan
LAU Stanley Chun Kwan
TSIM Karl Wah Keung
YU Jianzhen


2018 -




Investigation of the Chemical and Biological Properties of DNA-Protein Cross-Links formed by Abasic Sites using Mass Spectrometry-based Analytical Methods


利用質譜檢測技術研究由DNA缺鹼基位點導致的DNA-蛋白質交鏈的化學和生物學特徵 Leading


RGC - General Research Fund


Project Team (HKUST)
CHAN Simon Wan (Lead)


2018 - 2020




The genetic toxicology of PM2.5 exposure: A chemical approach to evaluate the impact of air pollution on human health Leading


Health and Medical Research Fund


Project Team (HKUST)
CHAN Simon Wan (Lead)
YU Jianzhen


2017 - 2020




Air quality monitoring research and carbon audit research Leading


CMA Industrial Development Foundation Limited


Project Team (HKUST)
CHAN Simon Wan (Lead)
FUNG Jimmy Chi Hung (Lead)


2011 -