LEE, Chi Sing Faculty








Educational Background B.Sc., Indiana University of Pennsylvania
Ph.D., University of Minnesota
Postdoctoral: Medicinal Chemistry Division, Pharmacia Corporation

Current Research Interests Natural Product Synthesis, Organic Methodology, Catalysis, Medicinal Chemistry, Chemical Biology and Molecular Imaging.


Selected PublicationsL. Zhu, W. Ma, M. Zhang, M. M.-L. Lee, W.-Y. Wong, B. D. Chan, Q. Yang, W.-T. Wong, W. C.-S. Tai, C.-S. Lee, “Scalable Synthesis Enabling Multilevel Bio-Evaluations of Natural Products for Discovery of Lead Compounds”, Nat.Commun., 9, 1283 (2018).
Q. Yang, W. Ma, G. Wang, W. Bao, X. Dong, X. Laing, L. Zhu, C.-S. Lee, “Tunable Cyclization Strategy for the Synthesis of Zizaene-, allo-Cedrane-, seco-Kaurane-, and seco-Atesane-Type Skeletons”, Org. Lett., 19, 5324 (2017).
T.-H. Tsoi, Y.-J. Gu, W.-S. Lo, W.-T. Wong, W.-T. Wong, C.-F. Ng, C.-S. Lee, K.-L. Wong, “Study on the aggregation of DNA capped gold nanoparticles: a smart and flexible aptasensor for spermine sensing”, ChemPlusChem , 82, 802 (2017).
G. Du, G. Wang, W. Ma, Q. Yang, W. Bao, X. Liang, L. Zhu, C.-S. Lee, “Syntheses of Diverse Natural Products via Dual-mode Lewis Acid Induced Cascade Cyclization Reactions”, Synlett, 28, 1394 (2017).
X. Liang, L. Zhou, L. Min, W. Ye, W. Bao, W. Ma, Q. Yang, F. Qiao, X. Zhang, C.-S. Lee, “Diastereoselective Total Synthesis of (±)-Basiliolide B and (±)-epi-8-Basiliolide B”, J. Org. Chem., 82, 3463 (2017).
Z. Liang, T.-H. Tsoi, C.-F. Chan, L. Dai, Y. Wu, G. Du, L. Zhu, C.-S. Lee, W.-T. Wong, G.-L. Law, K.-L. Wong, “A smart “off–on” gate for the in situ detection of hydrogen sulphide with Cu(II)-assisted europium emission”, Chem. Sci., 7, 2151 (2016).
G. Du, W. Bao, J. Huang, S. Huang, H. Yue, W. Yang, L. Zhu, Z. Liang, C.-S. Lee, “Enantioselective Synthesis of the ABC-Tricyclic Core of Phomactin A by a γ-Hydroxylation Strategy”, Org. Lett., 17, 2062 (2015).
W. Yang, J. Cao, M. Zhang, R. Lan, L. Zhu, G. Du, S. He, C.-S. Lee, “Systemic Study on the Biogenic Pathways of Yezo’otogirins: Total Synthesis and Antitumor Activities of (±)-Yezo’otogirin C and Its Structural Analogues”, J. Org. Chem., 80, 836 (2015).
L. Min, Y. Zhang, X. Liang, J. Huang, W. Bao, C.-S. Lee, “A Biomimetic Synthesis of (±)-Basiliolide B”, Angew. Chem. Int. Ed., 53, 11294 (2014).
S. He, W. Yang, L. Zhu, G. Du, C.-S. Lee, “Bioinspired Total Synthesis of (±)-Yezo’otogirin C”, Org. Lett., 16, 496 (2014). (Highlighted by E. M. Carreira in Synfacts)
L. Zhu, C. Zhou, W. Yang, S. He, G.-J. Cheng, X. Zhang, C.-S. Lee, “Formal Syntheses of (±)-Platensimycin and (±)-Platencin via a Dual-Mode Lewis Acid Induced Cascade Cyclization Approach”, J. Org. Chem., 78, 7912 (2013).
L. Zhu, Y. Han, G. Du, C.-S. Lee, “A Bifunctional Lewis Acid Induced Cascade Cyclization to the Tricyclic Core of ent-Kaurenoids and Its Application to the Formal Synthesis of (±)-Platensimycin”, Org. Lett., 15, 524 (2013).