王海天教授
BSc (HKUST), PhD (HKUST)
Associate Professor
Email: maggiew @ cuhk.edu.hk
ORCID:0000-0003-1223-4595
Researcher ID: F-5954-2017
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Academic Appointments
Co-Director, Master of Science Program in Epidemiology and Biostatistics, CUHK
Review Editor, Human Genetics
Biography
Dr. Maggie H Wang received her bachelor degree (Hon) in Physics. She obtained her PhD degree in Statistics from Hong Kong University of Science and Technology (HKUST) (advisor: Inchi Hu, Topic: A classification method incorporating interaction effect in high dimensional data). After graduation in 2011, Dr. Wang joined the School of Public Health and Primary Care, the Chinese University of Hong Kong (CUHK), first as a Research Assistant Professor, and was promoted to Assistant Professor in 2015 and Associate Professor (tenured) in 2021. She actively collaborates with biomedical scientists, clinical scientists, microbiologists and virologists, while keeping developing new bioinformatics methods to solve problems in genetic datasets. She visited Columbia University in 2009 and Stanford University in 2016 as a visiting scholar. She is the Principal Investigator of General Research Fund (GRF), National Natural Science Foundation of China (NSFC) general projects, and Health and Medical Research Fund (HMRF) in Hong Kong SAR.
Research Interests
Dr. Maggie Wang’s research focus is statistical genetics and bioinformatics with two major areas of application, infectious disease genome and human genome interpretation. In human genome, Wang’s group develops novel statistical methods and tools to identify disease susceptible biomarkers and to improve disease prediction accuracy. In influenza genome research, Wang’s group proposed new methods to bridge genetics and epidemiology and capture viral mutation patterns towards vaccine antigen optimization.
Recent Funded Research Projects
PI, Health and Medical Research Fund (HMRF) commissioned research on the Novel Coronavirus Diseases (COVID-19): Characterizing whole genome stability of the novel coronavirus SARS-CoV-2. PI: Maggie Wang, 2020/04/01 – 2023/03/31
PI of sub-project, Health and Medical Research Fund (HMRF) 2018/19, Sub-project title: Real-time surveillance of influenza viral evolution and antigenic mutation estimation, 01/09/2019 – 31/08/2022
PI, National Natural Science Foundation of China (NSFC) – General Project, Improving prediction accuracy of Alzheimer's Disease by Incorporating a novel feature selection method, 01/01/2019/ - 31/12/2022
PI, National Natural Science Foundation of China (NSFC) – General Project, Tracking pattern of amino acids underlying seasonal influenza, 01/01/2015 – 31/12/2018
Selected Publications
Xiaoxuan Xia, William K.K. Wu, Sunny H. Wong, Dabin Liu, Thomas N.Y. Kwong, Geicho Nakatsu, Pearlly S. Yan, Yu-Ming Chuang, Michael W.Y. Chan, Olabisi O. Coker, Zigui Chen, Yun K. Yeoh, Liuyang Zhao, Xiansong Wang, Wing Y. Cheng, Matthew T.V. Chan, Paul K.S. Chan, Joseph J.Y. Sung, Maggie H Wang*, Jun Yu* (2020) (co-corresponding author) Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer. Microbiome. IF=10.465, Rank 7/149 in Microbiology
Chan MC, Wang MH, Chen Z, Hui DS, Kwok AK, Yeung AC, Liu KM, Yeoh YK, Lee N, Chan PK. Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996–2012. Emerging infectious diseases. (2018) Oct;24(10):1825. IF = 8.22. Rank 3/84
Maggie Haitian Wang*, Haoyi Weng+, Rui Sun, Jack Lee, William Ka Kei Wu, Ka Chun Chong, Benny Chung-Ying Zee (2017) A Zoom-Focus Algorithm (ZFA) to locate the optimal testing region for rare variant association tests. Bioinformatics, IF=7.2. Corresponding author
Maggie Haitian Wang, Rui Sun, Junfeng Guo, Haoyi Weng, Jack Lee, Inchi Hu, Pak Sham and Benny Chung-Ying Zee (2016). A fast and powerful W-test for pairwise epistasis testing. Nucleic Acids Research. IF=11.6.
Rui Sun, Haoyi Weng, Inchi Hu, Junfeng Guo, William K.K. Wu, Benny Chung-Ying Zee, Maggie Haitian Wang* (2016) A W-test collapsing method for rare variant association testing in exome sequencing data. Genetic Epidemiology. DOI: 10.1002/gepi.22000.
Maggie Haitian Wang*, Billy Chang, Rui Sun, Inchi Hu, Marc Ka Chun Chong, Benny Chung Ying Zee (2017), A Stratified Polygenic Risk Prediction Model with Application on CAGI Bipolar Disorder Sequencing Data. Human Mutation. 2017 Sep;38(9):1235-9. Rank 24/171 in Genetics & Heredity Science. IF=5.359. https://doi.org/10.1002/humu.23229
Maggie Haitian Wang*, Heather Cordell, Kristel Van Steen (2019) Statistical Methods for Genome-wide Association Studies. Seminars in Cancer Biology. 2019 April. Rank 13/223 in Oncology. IF = 10.198 Doi: 10.1016/j.semcancer.2018.04.008
Xiaoxuan Xia, Haoyi Weng, Rui Sun, Ka Chun Chong, Benny Chung Ying Zee*, Maggie Haitian Wang* Incorporating methylation genome information improves prediction accuracy for drug treatment responses. BMC Genetics. 2018 Sep;19(1):78. IF = 2.569 Doi: 10.1186/s12863-018-0644-5 (supervisor of the first author)
Maggie Haitian Wang+, Ka Chun Chong+, Hau Yin Chung, Malina Storer, John Pickering, Zoltan Endre, Steven Lau, Chloe Kwok, Maria Lai, Benny Zee (2016). Use of a Least Absolute Shrinkage and Selection Operator (LASSO) Model to Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) Analysis of Exhaled Breath to Predict the Efficacy of Dialysis. Journal of Breath Research 10 (2016) 046004.
Maggie Haitian Wang, Shaw-Hwa Lo, Tian Zheng and Inchi Hu (2012) A Classification Method Incorporating Interactions among Variables for High-dimensional Data. Bioinformatics (2012) 28 (21): 2834-2842
Last Updated: 22 July2020
