莫家斌教授
BSc (Chem) (HKUST), MPhil (HKU), PhD (HKU)
Assistant Professor
Email: kapunmok @ cuhk.edu.hk
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ORCID:0000-0002-0525-6772
Scopus Author ID:36159732100
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Academic Appointments
Associate Editor, Frontier of Immunology
Associate Editor, Virology Journal
Member of Outbreak Investigation Task Force, Institute Pasteur International Network
Honorary Assistant Professor, HKU-Pasteur Research Pole, The University of Hong Kong
Biography
The major objective of our group is to understand the interplay between the host adaptive immunity and the viral determinants of respiratory viruses such as influenza viruses and coronaviruses using a combination of clinical, virological, immunological and structural approaches. We are particularly interested to understand how the adaptive immunity is regulated and sharpen by the evolution of respiratory viruses which will help to further improve the current vaccines.
Research Interests
Pathogenicity of zoonotic viruses in human
Viral immunology on respiratory diseases
Prophylactic and treatment options for respiratory infection
Selected Publications
Arunachalam PS*, Wimmers F*, Mok CKP*, Perera M*, Scott M, Hagan T, Sigal N, Feng Y, Bristow L, Tsang OT, Wagh D, Coller J, Pellegrini KL, Kazmin D, Alaaeddine G, Leung WS, Chan JMC, Chik TSH, Choi CYC, Huerta C, McCullough MP, Lv H, Anderson E, Edupuganti S, Upadhyay AA, Bosinger SE, Maecker HT, Khatri P, Rouphael N, Peiris M, Pulendran B. Systems biological assessment of immunity to severe and mild COVID-19 infections. Science. 369:1210-1220. [IF 41, Rank 2/69, Multidisciplinary Sciences] (*co-first authors).
Yuan M, Wu NC, Zhu X, Lee CCD, So RTY, Lv H, Mok CKP*, Wilson IA* (2020) A highly conserved cryptic epitope in the receptor-binding 4 domains of SARS-CoV-2 and SARS-CoV. Science 368:630-633 [IF 41, Rank 2/69, Multidisciplinary Sciences] (*co-corresponding authors). (Selection by C&EN’s Year in Chemistry 2020)
Mok CKP, Zhu A, Zhao J, Lau EHY, Wang J, Chen Z, Zhuang Z, Wang Y, Wang W, Tan W, Liang W, Oladipo JO, Kuranga SA, Peiris M, Zhao J (2020) Specific T cell responses provide evidence of MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria. Lancet Infect Dis 6:S1473-3099(20)30599-5. [IF 27.5, Rank 1/89, Infectious Diseases]
Hachim A, Kavian N, Cohen CA, Chin AWH, Chu DKW, Mok CKP, Tsang OTY, Yeung YC, Perera RAPM, Poon LLM, Peiris JSM, Valkenburg SA (2020) ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection. Nat Immunol 21(10):1293-1301 [IF 23.5, Rank 2/158, Immunology]
Lv H, Wu NC, Tsang OT, Yuan M, Perera RAP, Leung WS, So RT, Chan JMC, Yip GK, Chik TSH, Wang Y, Choi CYC, Lin Y, Ng WW, Zhao J, Poon LLM, Peiris JSM, Wilson IA, Mok CKP (2020) Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections. Cell Rep, 31(9):107725. [IF 7.8, Rank 29/193, Cell Biology] (Best papers in Cell Reports, 2020)
Wu NC, Lv H, Thompson AJ, Wu DC, Ng WWS, Kadam RU, Lin CW, Nycholat CM, McBride R, Liang W, Paulson JC, Mok CKP*, Wilson IA* (2019) Preventing an antigenically disruptive mutation in egg-based H3N2 seasonal influenza vaccines by mutational incompatibility. Cell Host Microbe 25:836-844 [IF 15.7, Rank 1/36, Virology] (*co-corresponding authors).
Guan W, Wu NC, Lee HHY, Li Y, Jiang W, Shen L, Wu DC, Chen R, Zhong N, Wilson IA, Peiris M, Yang Z, Mok CK (2018) Clinical correlations of transcriptional profile in patients infected with avian influenza H7N9 Virus. J Infect Dis 218:1238-1248. [IF 5.0, Rank 10/89, Infectious Diseases]
Ke C*, Mok CKP*, Zhu W*, Zhou H, He J, Guan W, Wu J, Song W, Wang D, Liu J, Lin Q, Chu DKW, Yang L, Zhong N, Yang Z, Shu Y, Peiris JSM (2017) Human infection with highly pathogenic avian influenza A(H7N9) virus, China. Emerg Infect Dis 23:1332-1340 [IF 7.2, Rank 5/89, Infectious Diseases] (*co-first author).
Yang ZF*, Mok CK*, Peiris JSM, Zhong NS (2015) Human infection with a novel avian influenza A(H5N6) virus. N Engl J Med 373:487-489 [IF 70.7, Rank 1/160, Medicine, General & Internal] (*co-first author).
Chan MC*, Chan RW*, Chan LL*, Mok CK*, Hui KPY, Fong JHM, Tao KP, Poon LL, Nicholls JM, Guan Y, Peiris JS (2013) Tropism and innate host responses of a novel avian origin influenza A (H7N9) virus in ex vivo and in vitro cultures of the human respiratory tract. Lancet Resp Med 1:534-542 [IF 23.0, Rank 1/63, Respiratory System] (*co-first author).
Last Updated: 3 May 2021
