Prof. Lin Zhang
BM (Hons), PhD
Assistant Professor,
Department of Medicine and Therapeutics Assistant Professor (by courtesy),
Department of Anaesthesia and Intensive Care
Faculty of Medicine
The Chinese University of Hong Kong

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Research Interests
Microbiome, Antimicrobial peptide, Autophagy, Infectious diseases
Publications:
For details about citations arising from my publications and links to online versions of some of the publications, refer to:
http://www.researcherid.com/rid/O-9109-2015 (Researcher ID: O-9109-2015)
( *corresponding author)



2020

Li Q, Hu W, Liu WX, Zhao LY, Huang D, Liu XD, Chan H, Zhang Y, Zeng JD, Coker OO, Kang W, Ng SSM, Zhang L, Wong SH, Gin T, Chan MTV*, Wu JL*, Yu J*,Wu WKK* (2020)Streptococcus thermophilusinhibits colorectal tumorigenesis through secreting beta-galactosidase.Gastroenterologydoi: 10.1053/j.gastro.2020.09.003. [Epub ahead of print]

Li Z, Li X, Shen J*, Tan H, Rong T, Lin Y, Feng E, Chen Z*, Jiao Y, Liu G, Zhang L, Chan MTV,Wu WKK* (2020) Bioinformatic analysis of SMN1-ACE/ACE2 interactions hinted at a potential protective effect of spinal muscular atrophy against COVID-19-induced lung injury.Brief Bioinform[In press]

Ho J^, Chan H^, Liang Y^, Liu X^, Zhang L^, Li Q, Zhang Y, Zeng J, Ugwu FN, Ho IHT, Hu W, Yau JCW, Wong SH, Wong WT, Ling L, Cho CH, Gallo RL, Gin T, Tse G, Yu J, Chan MTV*, Leung CCH*,Wu WKK* (2020) Cathelicidin preserves intestinal barrier function in polymicrobial sepsis.Crit Care24(1):47.

Kong KY, Kwong TNY, Chan H, Wong K, Wong SSY, Chaparala AP, Chan RCY, Zhang L, Sung JJY, Yu J, Hawkey PM, Ip M,Wu WKK*, Wong SH* (2020) Biological characteristics associated with virulence inClostridioides difficileribotype 002 in Hong Kong.Emerg Microbes Infect9(1):631-638.

Wang K, Liu X, Liu Q, Ho IHT, Wei X, Yin T, Zhan Y, Zhang W, Zhang W, Chen B, Gu J, Tan Y, Zhang L, Chan MTV,Wu WKK*, Du B*, Xiao J* (2020) Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells.Cell Death Dis11(8):611.

Hu W, Chan H, Lu L, Wong KT, Wong SH, Li MX, Gang XZ, Cho CH, Gin T, Chan MTV*,Wu WKK*, Zhang L* (2020) Autophagy in intracellular bacterial infection.Semin Cell Dev Biol101:41-50.

Li Z, Li X, Shen J, Zhang L, Chan MTV,Wu WKK(2020) Emerging roles of non-coding RNAs in scoliosis.Cell Prolif53(2):e12736.

Li Z, Li X, Xu D, Chen X, Li S, Zhang L, Chan MTV,Wu WKK(2020) An update on the roles of circular RNAs in osteosarcoma.Cell Prolifdoi: 10.1111/cpr.12936. [Epub ahead of print]

Li CKH, Xu Z, Ho J, Lakhani I, Liu Y, Bazoukis G, Liu T, Wong WT, Cheng SH, Chan MTV, Zhang L, Gin T, Wong MCS, Wong I,Wu WKK*, Zhang Q*, Tse G* (2020) Association of NPAC score with survival after acute myocardial infarction.Atherosclerosis301:30-36.
Yu X, Wang M, Li L, Zhang L, Chan MTV,Wu WKK(2020) MicroRNAs in atopic dermatitis: a systematic review.J Cell Mol Med24(11):5966-5972.

Klionsky DJ, ...,Zhang L,et al.(2020) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).Autophagydoi: 10.1080/15548627.2020.1797280. [Epub ahead of print]

Liu YZ, Chu R, Lee A, Gomersall CD, Zhang L, Gin T, Chan MTV,Wu WKK, Ling L (2020) A surveillance method to identify patients with sepsis from electronic health records in Hong Kong: a single centre retrospective study.BMC Infect Dis20(1):652.

Hu W, Zhang L,Wu WKK, Cho CH (2020) Involvement of autophagy in antibacterial actions of vitamin D inHelicobacter pyloriinfection: abridged secondary publication.Hong Kong Med J26 Suppl 4:26-28.





2019

Chen X^, Chan H^, Zhang L^, Liu X, Ho IHT, Zhang X, Ho J, Hu W, Tian Y, Kou S, Chan CS, Yu J, Wong SH, Gin T, Chan MTV*, Sun X*, Wu WKK*. (2019) The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux. J Cell Mol Med 23(6):4290-4300.

Hu W^, Zhang L^, Li MX^, Shen J^, Liu XD,? Xiao ZG,? Wu DL,? Ho IHT, Wu JCY,? Cheung CKY,? Zhang YC, Lau AHY,? Ashktorab H, Smoot DT,? Fang EF, Chan MTV,? Gin T,* Gong W,* Wu WKK,* Cho CH*. (2019)?? Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. Autophagy 15(4):707-725.

Ho J^, Li XC^, Zhang L^, Liang YH, Wong SH, Hu W, Yau JCW, Chan H, Chan MTV, Gin T, Tse G, Wu WKK. (2019) Translational genomics in pancreatic ductal adenocarcinoma: A review with re-analysis of TCGA dataset. Semin Cancer Biol pii: S1044-579X(17)30231-6.

Ng TH, Sham KWY, Xie CM, Ng SSM, To KF, Tong FHM Liu WYZ, Zhang L, Chan MTV, Wu WKK, Cheng CHK(2019). Eukaryotic elongation factor-2 kinases expression is an independent prognostic factor in colorectal cancer. BMC Cancer [In press]

Ho IHT, Liu X, Zou Y, Liu T, Hu W, Chan H, Tian Y, Zhang Y, Li Q, Kou S, Chan CS, Gin T, Cheng C, Wong SH, Yu J, Zhang L, Wu WKK*, Chan MTV* (2019) A novel peptide interfering with proBDNF-sortilin interaction alleviates chronic inflammatory pain. Theranostics 9(6):1651-1665.

Zhang Y, Zhang L, Yang L, Vong CI, Chan KF, Wu WKK, Kwong TNY, Lo NWS, Ip M, Wong SH, Sung JJY, Chiu PWY, Zhang L (2019) Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of C. diff toxins. Sci Adv 5(1):eaau9650.







2018

Zhang L^, Hu W^, Cho CH, Chan FKL, Yu J, Fitzgerald RJ,Cheung CKY, Xiao ZG, Jing Shen J,Li LF, Li MX,Wu JCY,Ling TKW,Chan JYK, Ho K, Tse G,Ng SC, Yu S, Wang MHT, Gin T, Ashktorab H, Duane T. Smoot DT,Wong SH*, Chan MTV*, Wu WKK*. (2018) Reduced lysosomal clearance of autophagosomes promotes survival and colonization ofHelicobacter pylori. J Pathol 244(4):432-444.


Zhang L^, Zhang Y^, Wong SH^, Law PTY, Zhao S, Yu J, Chan MTV*, Wu WKK* (2018) Common deregulation of seven biological processes by microRNAs in gastrointestinal cancers. Sci Rep 8(1):3287.


Zhang L^, Hu W^, Ho J, Fitzgerald RJ, Gin T, Chan MTV, Wu WKK*. (2018) Antimicrobial peptides in the host-microbiota homeostasis. In: Antimicrobial Peptides in Gastrointestinal Diseases: Elsevier [In press]


Chan H, Zhao S, Zhang L, Ho J, Leung CHH, Wong WT, Tian Y, Liu X, Kwong TNY, Chan RCY, Yu SSB, Wang MHT, Tse G*, Wong SH, Chan MTV, Wu WKK. (2018) Clostridium difficile toxin B induces autophagic cell death in colonocytes. J Cell Mol Med 22(4):2469-2477.


Shen J, Xiao ZG, Zhao QJ, Li MX, Wu X, Zhang L, Hu W, Cho CH (2018). Anti-cancer therapy with TNFa and INF ?: A comprehensive review. Cell Proliferation DOI:10:111/cpr.12441.


Xiao ZG, Shen J, Zhang L, Li MX, Hu W, Cho CH (2018). Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects. Oncology Letters 15:3395-3402.


Wu WKK, Zhang L, Chan MTV, Yu J (2018) Autophagy, NAFLD and NAFLD-related HCC. In: Obesity, Fatty Liver and Liver Cancer Singapore: Springer [In press]
Wang X^, Li X^,?Zhang L^, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T*, Chan MTV*, Wu WKK* (2018) Oncogenes expand during evolution to withstand somatic amplification.?Ann Oncol?[In press]?[IF =? 13.926]


Hu W^,?Zhang L^, Li MX^, Shen J^, Liu XD,? Xiao ZG,? Wu DL,? Ho IHT, Wu JCY,? Cheung CKY,? Zhang YC, Lau AHY,? Ashktorab H, Smoot DT,? Fang EF, Chan MTV,? Gin T,* Gong W,* Wu WKK,* Cho CH*. (2018) Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through PDIA3 receptor in gastric epithelial cells.?Autophagy?[IF2017=11.1]?[Ranked 25th?out of 284 in CELL BIOLOGY2017]?[Accepted]

Li DZ, Zhou YX, Yu HF, Yu J, Xia YQ, Zhang L, Wu WKK, Zhou YW, Xu SY, Zeng Z, Yao R, Cao Y. (2018) Evaluation of a novel prognostic score based on thrombosis and inflammation in patients with sepsis: a retrospective cohort study. Clin Chem Lab Med 56(7):1182-1192. ?







2017

Wong CMC, Zhang L*, Wu WKK, Shen J, Chan RLY, Lu L, Hu W, Li MX, Li LF, Ren SX, Li YF, Li J, Cho CH (2017) Cathelicidin-Encoding Lactococcus lactis Promotes Mucosal Repair in Murine Experimental Colitis. J Gastroen Hepatol 32(3):609-619.


Ho J, Dai RZW, Kwong T, Wang XS, Zhang L, Ip M, Chan RCY, Hawkey PM, Lam Y, Wong M, Tse G, Chan MTV, Chan FKL, Yu J, Ng SC, Lee N, Wu JC, Sung JJY, Wu WKK, Wong SH*. Disease burden of Clostridium difficile infection in adults from 2006 through 2014: Results from a territory-wide population study in Hong Kong. Emerg Infect Dis [In press]

Ho J, Zhang L, Liu X, Wong SH, Lau BWM, Ngai SPC, Chan H, Choi G, Leung CCH, Wong WT, Tsang S, Gin T, Yu J, Chan MTV, Wu WKK (2017) Pathological role and diagnostic value of endogenous host defense peptides in adult and neonatal sepsis: a systematic review. Shock 47(6):673-679.

Li MX, Li LF, Zhang L, Xiao ZG, Shen J, Hu W, Zeng Q, Cho CH (2017). Vitamin D and cancer stem cells in the Gastrointestinal Tract. Current Med Chem doi: 10.2174 /617. [Epub ahead of print].

Li MX, Li LF, Zhang L, Hu W, Shen J, Xiao ZG, Wu X, Chan FL, Cho CH (2017). 1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21. Life Sci doi: 10.1016/j.lfs.2017.04.021. Epub 2017 Apr 29.





2016

Zhang L*, Wu WKK, Gallo RL, Fang EF, Ling TKW, Shen J, Chan RLY, Lu L, Luo XM, Li MX, Chan KM, Yu J, Wong VWS, Ng SC, Wong SH, Chan FKL, Sung JJY, Chan MTV, Wu WKK, Cho CH (2016). Critical Role of Antimicrobial Peptide Cathelicidin for ControllingHelicobacter pylori Survival and Infection. ?J Immunol 15;196(4):1799-809.

Ho J, Yu J, Wong SH, Zhang L, Liu X, Wong WT, Leung CCH, Choi G, Wang MH, Gin T, Chan MTV, Wu WKK (2016).Autophagyin sepsis: Degradation into exhaustion?Autophagy 2;12(7):1073-1082. ?

Xiao ZG, Shen J, Zhang L, Li LF, Li MX, Hu W, Li ZJ, Cho CH (2016). The roles of histone demethylase UTX and JMJD3 (KDM6B) in cancers: Current progress and future perspectives. Curr Med Chem 23(32):3687-3696.

Wong SH, Kwong TNY, Chow TC, Luk AKC, Dai RZ, Nakatsu G, Zhang L, Lam, TYT, Wu JCY, Chan FKL, Ng SSM, Wong MCS, Ng SC, Wu WKK, Yu J, Sung JJY (2016). Quantitation of faecal Fusobacterium improves performance of faecal immunochemical test in detecting advanced colorectal neoplasia. Gut; 0:1–8. doi:10.1136/gutjnl-2016-312766.?

Shen J, Li WX, Xiao ZG, Zhang L, Li MX, Li LF, Hu W, Lu L, Boudreau F, Cho CH (2016). The Co-regulatory role of 5-Lipoxygenase and Cyclooxygenase-2 in the carcinogenesis and their promotion by Cigarette Smokeing in Colons. Curr Med Chem 23(11):1131-8.

Shen J, Li ZJ, Lu L, Xiao ZG, Wu WK, Zhang L, Li MX, Hu W, Chan KM, Cho CH (2016). Vascular-targeted TNFa and IFN? inhibits orthotopic colorectal tumor growth J Transl Med 14(1):187.

Wang L, Hu T, Shen J, Zhang L, Li LF, Chan RL, Li MX, Wu WKK, Cho CH. (2016). Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. Life Sci pii: S0024-3205(16)30134-5.






2015

Cho CH, Yu J, Zhang L, Wu WKK. (2015). The role of cathelicidin in control of Helicobacter pylori colonization in the stomach. Hong Kong Med J 21 Suppl 4:17-19.

Shen J, Xiao Z, Wu WKK, Wang MH, To KF, Chen Y, Yang W, Li MSM, Shin VY, Tong JH, Zhang L, Li M, Wang L, Lu L, Chan RLY, Wong SH, Yu J, Chan MTV, Chan FKL, Sung JJY, Cheng ASL, Cho CH (2015) Epigenetic silencing of miR-490-3preactivatesthechromatinremodelerSMARCD1to promoteHelicobacterpylori-induced gastriccarcinogenesis. Cancer Res 75(4): 754-65. ?

Lu L, Li ZJ, Li LF, Wu WKK, Shen J, Zhang L, Chan RLY, Yu L, Liu YW,
Ren SX, Chan KM, Cho CH. (2015). Vascular-targeted TNFa improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer. J Control Release 210, 134-146.

Luo MX, Wong SH, Chan MT, Yu L, Yu SS, Wu F, Xiao Z, Wang X, Zhang L, Cheng AS, Ng SS, Chan FK, Cho CH, Yu J, Sung JJ, Wu WKK. (2015). Autophagy mediates HBx-induced nuclear factor-?B activation and release of IL-6, IL-8 and CXCL2 in hepatocytes. J Cell Physiol 230, 2382-2389.

Ko CH, Chan RLY, Siu WS, Shumn WRT, Leung PC, Zhang L, Cho CH. (2015). Deteriorating effect on bone metabolism and microstructure by passive cigarette smoking through dual actions on osteoblast and osteoclast. Calcified Tissue Int 96, 389-400.






2014


Zhang L, Sung JJY, Yu J, Ng SC, Wong SH, Cho CH, Chan FKL, Wu WKK (2014). Xenophagy in Helicobacter pylori- and Epstein-Barr virus-induced gastric cancer. J Pathol 233(2):103-12.

Li LF, Chan RLY, Lu L, Shen J, Zhang L, Wu WKK, Wang L, Hu T, Li MX, Cho CH (2014) Cigarette smoking and gastrointestinal diseases: The causal relationship and underlying molecular mechanisms. Int J Mol Med 34(2):372-80.

Hu T, To KK, Wang L, Zhang L, Lu L, Shen J, Chan RL, Li M, Yeung JH, Cho CH (2014). Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza. Phytomedicine 25;21(11):1264-72.

Wu WKK, Sung JJY, Cheng ASL, Chan FKL, Ng SS, To KF, Wang XJ, Zhang L, Wong SH, Yu J, Cho CH (2014). The Janus faces of cathelicidin in tumorigenesis. Curr Med Chem 21(21):2392-400.





2013


Zhang L, Yu J, Wong CCM, Ling TKW, Li ZJ, Chan KM, Ren SX, Shen J, Chan RLY, Lee CC, Li MSM, Cheng ASL, To KF, Gallo RL, Sung JJY, Wu WKK, Cho CH (2013). Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice. Gene Ther 20:751-760.

Shen J, Wu WKK, Ren SX, Zhang L, Chan RL, Wong CC, Lu L, Cho CH (2013) miRNAs in Gastrointestinal and Liver Cancers: Their Perspectives and Clinical Applications. Curr Pharm Des 19(7):1301-10.

Ren SX, Shen J, Cheng ASL, Lu L, Chan RLY, Li ZJ, Wang XJ, Wong CCM, Zhang L, Ng SSM, Chan FL, Chan FKL, Yu J, Sung JJY, Wu WKK, Cho CH (2013) FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PLoS One 8: e63641.

Wang L, Yeung JH, Hu T, Lee WY, Lu L, Zhang L, Shen J, Chan RL, Wu WKK, Cho CH (2013) Dihydrotanshinone induces p53 independent but ROS dependent apoptosis in colon cancer cells. Life Sci 93(8):344-51.





2012

Zhang L, Ren JW, Wong CCM, Wu WKK, Ren SX, Shen J, Chan RLY, Cho CH (2012). Effects of cigarette smoke and its active components on ulcer formation and healing in the gastrointestinal mucosa. Current Med Chem 19:63-69.

Ren SX, Cheng ASL, To KF, Tong JHM, Li MS, Shen J, Wong CCM, Zhang L, Chan RLY, Wang XJ, Ng SSM, Chiu LCM, Marquez VE, Gallo RL, Chan FKL, Yu J, Sung JJY,Wu WKK,Cho CH (2012). Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer. Cancer Res 72(24); 1-12.

Wong CCM, Zhang L, Li ZJ, Wu WKK, Ren SX, Chen YC, Ng TB, Cho CH (2012). Protective Effects of Cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis. J Gastroen Hepatol. 27(7):1205-1212.

Chan RLY, Zhang L, Leung PL, Cho CH (2012). Osteoporosis and Cigarette Smoking: The Association and Future. Adaptive Medicine 4(2):57-63.

Fang EF, Zhang CZY, Zhang L, Fong WP, Ng TB (2012). In vitro and in vivo anticarcinogenic effects of RNase MC2, a ribonuclease isolated from dietary bitter gourd, toward human liver cancer cells. Int J Biochem Cell Biol.44(8):1351-1360.

Fang EF, Zhang CZY, Zhang L, Wong JH, Chan YS, Pan WL, Dan XL, Yin CM, Cho CH, Ng TB (2012).Trichosanthin inhibits breast cancer cell proliferation in both cell Lines and nude mice by promotion of apoptosis. PLoS One 7(9): e41592.