LIU, Guozhen
Adjunct Associate Professor

Education Background
PhD (University of New South Wales, Sydney, Australia)
BS（China University of Geosciences）
MS?(Huhei Normal University)

Research Field
Biomedical Engineering, Biosensors, Microfluidic paper-based biochips, Flexible wearables, 3D printing, In vitro point-of-care diagnostics, Intelligent nanoparticles and medical devices
Email
liuguozhen@cuhk.edu.cn
Biography
Professor Guozhen LIU is an associate professor in the school of life and Health Sciences of the Chinese University of Hong Kong (Shenzhen).
Prof LIU’s scientific career is alternating between academia and industry. Before joining CUHK(SZ), she worked as a tenured Associate Professor and Australian Research Council (ARC) Future Fellow of UNSW, She is also an Honorary Associate Professor at the Graduate School of Biomedical Engineering, University of New South Wales (UNSW), Sydney, Australia. After finishing her PhD under the supervising of Prof Justin Gooding at UNSW, Liu conducted her postdoctoral research at CSIRO and UNSW, respectively before she was appointed as an Associate Professor at Central China Normal University in 2009. In 2015 Liu moved back to Sydney and worked at Macquarie University before she was awarded the prestigious ARC Future Fellowship in 2016. From 2011 to 2015, she, as a R&D Manager (China), was leading a team to formulate and produce glucose test strips at AgaMatrix Inc, a US BioTech company to make products for diabetes. Meanwhile, Prof LIU is the co-founder at Bio-Sens Tech Pty Ltd, a Start-up company at Sydney, Australia.
Prof LIU is recognised for her interdisciplinary and translational research with close end-user engagement in the area of biomedical engineering. She aims to develop advanced biosensors, intelligent nanoparticles, and medical devices for precise theranostic, management and prevention of our immune system related chronic diseases such as diabetes, sepsis, Parkinson’s disease, depression, etc., and thus improve our health outcomes. Prof LIU?has published more than 100 peer-reviewed journal papers, 1 book chapter and 9?patents. Her patented technologies have attracted interests and funding from biomedical firms such as AstraZeneca, BioLegend, AgaMatrix Inc, Regeneus Ltd, etc. She has been awarded with over $5M research funding from both Australian government and industry since 2016 including more than $1M industry funding from the world top pharmaceutical company AstraZeneca. Prof Liu also attracted more than 1M RMB from National Natural Science Funds, China between 2009 and 2015. Among her many prestigious awards, she received the Rising Star Award by Australian Association of Chinese Biomedical Scientists (2018), and Australian Georgina Sweet Award for Women in Quantitative Biomedical Science (2020). Prof LIU?is currently serving as the Speciality Chief Editor for Biosensors and Biomolecular Electronics in Frontiers in Bioengineering and Biotechnology, special issue editor of Biosensors & Bioelectronics, and the vice-chair of IEEE Sensor Council NSW Chapter.
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Academic Publications
Selected peer-reviewed journal publications since 2016 (*corresponding author; Google citations: https://scholar.google.com.au/citations?user=xms_zr0AAAAJ&hl=en)
Topics on Microfluidic biochips for point-of-care diagnostics
1. V. Shirshahi,* G. Liu*, Enhancing the analytical performance of paper lateral flow assays: From chemistry to engineering, TrAC Trends Anal. Chem., 2021, 136, 116200, https://doi.org/10.1016/j.trac.2021.116200
2. Z. Luo, T. Lv, K. Zhu, Y. Li, L. Wang, J. J. Gooding, G. Liu*, B. Liu*, Paper-based Ratiometric Fluorescence Analytical Devices towards Point-of-Care Testing of Human Serum Albumin, Angew. Chem. Int. Ed., 2020, 59, 1-7, https://doi.org/10.1002/anie.201915046
3. M. Baharfar, M. Rahbar, M. Tajiki, G. Liu*, Engineering Strategies for Enhancing the Performance of Electrochemical Paper-Based Analytical Devices, Biosens. Bioelectron., 2020, 167, 112506, https://doi.org/10.1016/j.bios.2020.112506 ?
4. A. Hassanzadeh-Barforoushi*, M. Ebrahimiwarkiani, D. Gallego-Ortega, G. Liu, T. Barber, Capillary-assisted microfluidic biosensing platform captures single cell secretion dynamics in nanoliter compartments, Biosens. Bioelectron., 2020, 112113, https://doi.org/10.1016/j.bios.2020.112113
5. L. Liu, D. Yang, G. Liu*. Signal amplification strategies for paper-based analytical devices, Biosens. Bioelectron., 2019, 136, 60-75, https://doi.org/10.1016/j.bios.2019.04.043
6. B. V. Dang, A. Hassanzadeh-Barforoushi, M. S. Syed, D. Yang, S.-J. Kim, R. Taylor, G.-J. Liu, G. Liu*, Tracie Barber*. Microfluidic actuation via 3D-printed molds towards multiplex biosensing of cell apoptosis, ACS Sens., 2019, 482181-482189, https://doi.org/10.1021/acssensors.9b01057
Topics on CRISPR/Cas based biosensing technologies
7. Y. Li, S. Li, J. Wang, G. Liu*, CRISPR/Cas systems towards next generation biosensing, Trends in Biotechnology, 2019, 37 (7), 730-743, https://doi.org/10.1016/j.tibtech.2018.12.005
8. Y. Li, L. Liu, G. Liu*, CRISPR/Cas multiplexed biosensing: a challenge or an insurmountable obstacle? Trends in Biotechnology, 2019, 37(8), 792-795, https://doi.org/10.1016/j.tibtech.2019.04.012
9. Y. Dai, Y. Wu, G. Liu, J. J. Gooding, CRISPR mediated biosensing toward understanding cellular biology and point-of-care diagnosis, Angew. Chem. Int. Ed., 2020, 132, 20938-20950, https://doi.org/10.1002/ange.202005398
10. L. Peng, J. Zhou, G. Liu, L. Yin, S. Ren, S. Li*, L. Ma*, CRISPR-Cas12a based aptasensor for sensitive and selective ATP detection, Sens. Actuators B: Chem, 2020, 128164, 1-5, https://doi.org/10.1016/j.snb.2020.128164
11. J. Zhou, L. Yin, Y. Dong, L. Peng, G. Liu, S. Man, L. Ma*, Cas13a Based Bacterial Detection Platform: Sensing Pathogen Staphylococcus aureus in Food Samples, Anal. Chim. Acta, 2020, 1127, 225-233, https://doi.org/10.1016/j.aca.2020.06.041
Topics on Wearable biosensing devices
12. M. R. Benzigar, V. D.B.C Dasireddy, X. Guan, T. Wu, G. Liu*, Advances on emerging materials for flexible supercapacitors: current trends and beyond, Adv. Funct. Mater., 2020, 2002993, 1-41, https://doi.org/10.1002/adfm.202002993
13. L. Qiao, M. Benzigar, A. Subramony, N. Lovell, G. Liu*, Advances in Sweat Wearables: Sample Extraction, Real-Time Biosensing, and Flexible Platforms, ACS Appl. Mater. Interfaces, 2020, 12, 30, 34337–34361, https://doi.org/10.1021/acsami.0c07614?
14. G. Liu*, C. Cao, H. Wei, S. Feng, S. Ni, On-Chip Structure-Switching Aptamer Modified Magnetic Nanobeads for Continuous Monitoring of Interferon-gamma Ex Vivo, Microsys. Nanoeng., 2019, (2019) 5:35, 1-11, https://doi.org/10.1038/s41378-019-0074-1?
15. M. Qi, J.W. Huang, H. Wei, C.M. Cao, S.L. Feng, Q. Guo, E.M. Goldys, R. Li, G. Liu*, Graphene oxide thin film with dual function integrated into a nano-sandwich device for in vivo monitoring of interleukin-6, ACS Appl. Mater. Interfaces, 2017, 9(48), 41659-41668, https://doi.org/10.1021/acsami.7b10753
Topics on Deployable in vivo biosensing devices for monitoring of cytokines
16. C. Cao, R. Jin, H. Wei, Z. Liu, S. Ni, G-J Liu, H. A. Young, X. Chen*, G. Liu*, Adaptive in vivo device for theranostics of inflammation: real-time monitoring of interferon-gamma and aspirin, Acta Biomaterialia, 2020, 101, 372-383, https://doi.org/10.1016/j.actbio.2019.10.021
17. Z. Shen, J. Huang, H. Wei, H. Niu, B. Li, R. Li, G. Liu*, Validation of an in vivo electrochemical immunosensing platform for simultaneous detection of multiple cytokines in Parkinson’s Disease mice model, Bioelectrochemistry, 2020, 134, 107532, https://doi.org/10.1016/j.bioelechem.2020.107532
18. A. Arman, F. Deng, E. M. Goldys, G. Liu*, M. R. Hutchinson*, In vivo intrathecal IL-1β quantification in rats: monitoring the molecular signals of neuropathic pain, Brain Behav. Immu., 2020, 88, 442-450, https://doi.org/10.1016/j.bbi.2020.04.009
19. F. Deng, E.M. Goldys, G. Liu*, Molecularly imprinted polymer-based reusable biosensing device on stainless steel for spatially localized detection of cytokine IL-1β, Sens. Actuators B: Chem., 2019, 292, 277-283, https://doi.org/10.1016/j.snb.2019.04.142
20. F. Zhang, F. Deng, G-J Liu, R. Middleton, D. Inglis, A. Anwer, S. Wang, G. Liu*, IFN-γ-induced signal-on fluorescence aptasensors: from hybridization chain reaction amplification to 3D optical fiber sensing interface towards a deployable device for cytokine sensing, Mol. Sys. Design Eng., 2019, 4, 872-881, https://doi.org/10.1039/C9ME00047J
21. C. Cao, F. Zhang, E. M. Goldys, F. Gao, G. Liu*, Advances in structure-switching aptasensing towards real-time detection of cytokines, TrAC Trends Anal. Chem., 2018, 102, 379-396, https://doi.org/10.1016/j.trac.2018.03.002
22. C. Cao. R. Jin, H. Wei, W. Yang, E. Goldys, M. R. Hutchinson, S. Liu, X. Chen*, G. Yang, G. Liu*, Graphene Oxide Based Recyclable In vivo Device for Amperometric Monitoring of Interferon-γ in Inflammatory Mice, ACS Appl. Mater. Interfaces, 2018, 10 (39), 33078–33087, https://doi.org/10.1021/acsami.8b13518
23. H. Wei, S.N. Ni, C.M. Cao, G. F. Yang, G. Liu*, Graphene oxides signal reporters based multifunctional immunosensing platform for amperometric profiling of multiple cytokines in serum, ACS Sens., 2018, 3(8), 1553-1561, https://doi.org/10.1021/acssensors.8b00365
24. M. Qi, Y. Zhang, C.M. Cao, M. Zhang, S. Liu, G. Liu*, Decoration of RGO nanosheets with aryldiazonium salt and gold nanoparticles towards a label-free amperimetric immunosensor for detecting TNF-a in live cells, Anal. Chem., 2016, 88(19), 9614-9621, https://doi.org/10.1021/acs.analchem.6b02353
Topics on Intelligent nanoparticles for nanomedicine
25. Clement, J. M. Campbell, W. Deng, A. Guller, S. Nisar, G. Liu, B. C. Wilson*, E. M. Goldys*, Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer, Adv. Sci., 2020, 7(24), 2003584, https://doi.org/10.1002/advs.202003584
26. G. Liu*, C. Bursill, S. P. Cartland, A. G. Anwer, L. M. Parker, K. Zhang, S. Feng, M. He, D. W. Inglis, M. M. Kavurma, M.R. Hutchinson, E. M Goldys*, A nanoparticle-based affinity sensor that identifier and select highly cytokine-secreting cells, iScience, 2019, 20, 137-147, https://doi.org/10.1016/j.isci.2019.09.019
27. K. Wen, X. Xu, J. Chen, L. Lv, L. Wu, Y. Hu, X. Wu, A. Peng, G. Liu, H. Huang*, Triplet Tellurophene-based Semiconducting Polymer Nanoparticles for Near-Infrared-mediated Cancer Theranostics, ACS Appl. Mater. Interfaces, 2019, 11, 19, 17884-17893, https://doi.org/10.1021/acsami.9b05196
28. T. Jiang, L. Zhou, H. Liu, P. Zhang*, G. Liu, P. Gong, C. Li, W. Tan, J. Chen, L. Cai*, A Monitorable Mitochondria-targeting DNAtrain for Image-guided Synergistic Cancer Therapy, Anal. Chem., 2019, 91, 6996-7000, https://doi.org/10.1021/acs.analchem.9b01777
29. K. Ma, G-J. Liu, L. Yan, S. Wen, B. Xu, W. Tian, E. Goldys, G. Liu*, AIEgen based PLGA magnetic nanoparticles to localize cytokine VEGF for early diagnosis and photothermal therapy, Nanomedicine, 2019, 14(9). 1191-1201, https://doi.org/10.2217/nnm-2018-0467
30. K. Ma, F., Zhang, N. Sayyadi, W. J. Chen, A. Anwer, A. Care, B. Xu, W. J. Tian, E. M. Goldys,G. Liu*, Turn-on fluorescent aptasensor based on AIEgen labelling for the localisation of IFN-y in live cells, ACS Sens., 2018, 3(2), 320-326. https://pubs.acs.org/doi/10.1021/acssensors.7b00720
31. G. Liu*, K. Zhang, K. Ma, A. Care, M.R. Hutchinson, E. M. Goldys, Graphene quantum dots based "switch-on" nanosensors for intracellular cytokine monitoring, Nanoscale, 2017, 9, 4934-4943, https://doi.org/10.1039/C6NR09381G
32. X. Gong, G. Liu, Y. Li, Y. Yu, W.Y*. Teoh, Functionalized-graphene composites: Fabrication and applications in sustainable energy and environment, Chem. Mater., 2016, 28(22), 8082-8118. https://doi.org/10.1021/acs.chemmater.6b01447