Prof. DUAN, Liting
Assistant Professor, Department of Biomedical Engineering, CUHK

ltduan@cuhk.edu.hk
Tel: 3943 8268
Location: ERB1116

Lab webpage: ltduan.com


About
Liting received a Bachelor degree in Chemistry from Renmin University of China (People’s University ofChina) in 2010 where she worked on the fabrication and application of micro/nano-patterned structuresusing hot micro-contact printing. She moved from material engineering to biochemistry/biophysics for herdoctoral studies at Stanford University (Ph.D. in Chemistry 2016). Her thesis focused on the development ofoptogenetic strategies to control intracellular activities. During postdoctoral research, she further studiedand engineered the photosensory proteins interactions for optimized optogenetic toolkit at Stanford. InJuly 2018, she joined the Department of Biomedical Engineering in the Chinese University of Hong Kong asan Assistant Professor.


Professional Education and Training
2016 Ph.D. in Chemistry, Stanford University
2010 B.S. in Chemistry, Renmin University of China


Research Interest
· Development of optogenetic strategies to control intracellular activities;
· Intracellular signaling;
· Organelle dynamics;


Course Teaching in CUHK
BMEG2011 Biomedical Engineering Laboratory and Hospital Experience
BMEG3140 Molecular and Cellular Engineering Laboratory
BMEG3330 Neuroengineering
ENGG5601 Biomechanics & Biomaterials


HONORS & AWARDS
2021 Dean’s Exemplary Teaching Award, The Chinese University of Hong Kong


Selected Publications
Y. Song, P. Huang, X. Liu, Z. Zhao, Y. Wang, B. Cui*, L. Duan*. Light-inducible Deformation of Mitochondria in Live Cells. Cell Chemical Biology. (2021).

P. Huang, Z. Zhao, L. Duan*. Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions. Neural Regeneration Research. (2022) Jan;17(1):25-30.

P. Huang, A. Liu, Y. Song, J. Hope, B. Cui, L. Duan*. Optical activation of TrkB signaling. J. Mol. Biol. (2020). 432(13), 3761.

P. Huang, Y. Song, N. Zhang, Z. Zhao, L. Duan*. Optogenetics based on light-gated protein-protein interactions and its applications. Chinese Journal of Lasers. (2020). 47(2), 0207010.

H.Y. Lou, W. Zhao, X. Li, L. Duan, A. Powers, M. Akamatsu, F. Santoro, A.F. McGuire, Y. Cui*, D.G. Drubin* & B. Cui*. Membrane curvature underlies actin reorganization in response to nanoscale surface topography. Proc Natl Acad Sci U S A (2019).

L. Duan? , J. Hope?, S. Guo?, Q. Ong, A. Fracois, L. Kaplan, G. Sherrer, B Cui*. Optogenetic control of TrkA signaling. ACS Synth. Biol., 2018, 7 (7), 1685.

L. Duan, J. Hope, Q. Ong, H. Lou, N. Kim, C. McCarthy, V. Acero, M. Lin*, B. Cui*. Understanding CRY2 interactions for optical control of intracellular signaling. Nat. Commun., 2017, 8(1),547.

L. Duan?, D. Che?, K. Zhang, Q. Ong, S. Guo, B. Cui*. Optogenetic control of molecular motors and organelle distributions in cells. Chem. Biol., 2015, 22(5), 671.

D. Che? , L. Duan? , K. Zhang, B. Cui*. The dual characteristics of light-induced cryptochrome 2 homo-oligomerization and hetero-dimerization for optogenetic manipulation in mammalian cells. ACS Syn. Biol., 2015, 4 (10), 1124.