Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 朱睿博士 (耳鼻咽喉-头颈外科学系) |
| 陈功教授 (外科学系) |
| 陈碧云教授 (病理解剖及细胞学系) |
| 范大华博士 (外科学系) |
| 吴国伟教授 (外科学系) |
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
| Professor VLANTIS Alexander Chris (耳鼻咽喉-头颈外科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.mce.2014.10.006 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/8WOS source URL
其它资讯
摘要Foxp3+ regulatory T cells (Tregs) in lymphocytes facilitate the thyroid tumor growth and invasion. Very limited information is available on Foxp3 expression in thyroid cancer cells and its function is totally unknown. This study demonstrated that Foxp3 expression was increased in thyroid cancer cells. Inhibition of Foxp3 decreased cell proliferation and migration, but increased apoptosis, suggesting a positive role of Foxp3 in cancer growth. Interestingly, Foxp3 inhibition enhanced PPAR gamma expression and activity. In addition, Foxp3 inhibition downregulated NF-kappa B subunit p65 and cyclin D1 but upregulated caspase-3 levels. These molecular changes are in line with Foxp3 shRNA-mediated alteration of cell functions. Collectively, our study demonstrates that thyroid cancer cells express a high level of functional Foxp3 and that the inhibition of the Foxp3 suppresses the proliferation and migration but promotes apoptosis, suggesting that targeting Foxp3 in thyroid cancer cells may offer a novel therapeutic option for thyroid cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
着者Chu R, Liu SYW, Vlantis AC, van Hasselt CA, Ng EKW, Fan MD, Ng SK, Chan ASW, Du J, Wei W, Liu XL, Liu ZM, Chen GG
期刊名称MOLECULAR AND CELLULAR ENDOCRINOLOGY
出版年份2015
月份1
日期5
卷号399
期次C
出版社ELSEVIER IRELAND LTD
页次22http://aims.cuhk.edu.hk/converis/portal/Publication/8 - 234
国际标準期刊号0303-7207
语言英式英语
关键词Apoptosis; Foxp3; PPAR gamma; Thyroid cancer
Web of Science 学科类别Cell Biology; Endocrinology & Metabolism
