Chapter in an edited book (author)
香港中文大学研究人员 ( 现职)
| 陈功教授 (外科学系) |
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
| 吴国伟教授 (外科学系) |
| Professor VLANTIS Alexander Chris (耳鼻咽喉-头颈外科学系) |
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| 没有全文档案提供 |
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Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/0Scopus source URL
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摘要Iodine is the essential element for humans. Proper intake of dietary iodine is considered crucial for the prevention of thyroid diseases. Epidemiological and animal model studies suggest that lower iodine supplements or exposure may promote the thyroid cancer transformation from differentiated to anaplastic form. Further studies disclose that iodine-induced cell cycle arrest and apoptosis may provide clues to the underlying mechanisms. Iodine transporters, sodium iodide symporter, pendrin, and apical iodide transporter, are responsible for the transport of iodine into, through and out of thyroid cancer cells. Better understanding the roles of iodine transporters has provided molecular definition to the role of iodine metabolism in thyroid carcinogenesis and therapy. A number of studies have directly demonstrated that these proteins play crucial roles in tumorigenesis and development through interfering with multiple cell signaling pathways. This chapter provides an insight into the potential mechanisms of iodine and iodine transporters which influence the formation and progression of thyroid cancer through regulating a number of cell signaling pathways controlling cell proliferation, cell survival and/or apoptosis. ? 2http://aims.cuhk.edu.hk/converis/portal/Publication/012 Nova Science Publishers, Inc. All rights reserved.
着者Liu X.H., Vlantis A.C., Ng E.K.W., Liu S.Y.W., van Hasselt C.A., Chen G.G.
编辑ed. by Adelina H. Martinez and Edelmiro J. Perez.
详细描述ed. by Adelina H. Martinez and Edelmiro J. Perez.
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/012
月份12
日期1
页次53 - 72
国际标準书号9781619427http://aims.cuhk.edu.hk/converis/portal/Publication/082
语言英式英语
关键词Apoptosis, Carcinogenesis, Cell proliferation, Genetic alterations, Iodine, Iodine transporters, Signaling pathway, Thyroid cancer
