Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
| 唐志辉教授 (耳鼻咽喉-头颈外科学系) |
| Professor VLANTIS Alexander Chris (耳鼻咽喉-头颈外科学系) |
| 陈功教授 (外科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.2174/138945008785909257 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/7WOS source URL
其它资讯
摘要Laryngeal cancer is a common head and neck cancer. Despite advances in treatment, improvement in survival and quality of life of patients still remains a challenge. Chemotherapy has become more and more important since this treatment is able to preserve laryngeal function. There is increasing evidence showing that many chemotherapeutic agents kill laryngeal tumor cells via apoptotic mechanisms. The balance between anti-apoptotic molecules and pro-apoptotic ones plays a critical role in determining the sensitivity of the tumor cells to chemotherapy. The commonly used chemotherapeutic agents for laryngeal cancer include cisplatin, 5-fluorouracil and paclitaxel. These three agents may target common apoptotic molecules, but more importantly they have their own particular targets. Systemically analysis of these targets will not only help to optimize the treatment but also provide a rationale for the best combination of two or more agents for the chemotherapy of laryngeal cancer.
着者Liu HC, Chen GG, Vlantis AC, Tong MCF, van Hasselt CA
期刊名称Current Drug Targets
出版年份2008
月份10
日期1
卷号9
期次10
出版社Bentham Science Publishers
页次8http://aims.cuhk.edu.hk/converis/portal/Publication/78 - 886
国际标準期刊号1389-4501
电子国际标準期刊号18http://aims.cuhk.edu.hk/converis/portal/Publication/73-5592
语言英式英语
关键词5-fluorouracil; apoptosis; cisplatin; Laryngeal cancer; paclitaxel
Web of Science 学科类别Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
