Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
| 黄约爱博士 (中医学院) |
| 陈功教授 (外科学系) |
| 梁秉中教授 (中医中药研究所) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/10WOS source URL
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摘要There are many animal models for studying allergic rhinitis. However, they either need a too long establishment period or fail to show significant late allergic responses. In the model described in this paper, guinea pigs were sensitized and challenged intranasally with ovalbumin according to a modified protocol. As controls, antihistamine-treatment and non-sensitized, non-treatment groups were studied in parallel. Early and late symptoms, passive cutaneous anaphylaxis (PCA) reaction, nitric oxide synthase (NOS) immunoreactivities, pathological changes in nasal mucosa and nasal lavage fluid (NLF), and histamine, TXB2 and pLTs levels in NLF were evaluated. In contrast to the control groups, the model group exhibited typical symptoms, including late phase nasal blockage, and increased levels of IgG(1) and IgE. Considerable eosinophil infiltration and eNOS immunoreactivities in nasal mucosa, and increased levels of histamine, TXB2 and p-LTs in NLF were also observed. This model was not only capable of showing satisfactory symptomatic and pathophysiological changes in allergic rhinitis but also showed good responses to antihistamine treatment. The model can be established in six weeks. For the first time, respiratory rate was employed as an index to reflect the nasal blockage of guinea pigs and it proved to be a reliable indicator.
着者Zhao Y, Woo JKS, Leung PC, Chen GG, Wong YO, Liu SX, van Hasselt CA
期刊名称Rhinology
出版年份2005
月份3
日期1
卷号43
期次1
出版社INT RHINOLOGIC SOC
页次47 - 54
国际标準期刊号0300-0729
语言英式英语
关键词allergic rhinitis; animal model; nasal blockage; nasal lavage fluid; nitric oxide synthase
Web of Science 学科类别Otorhinolaryngology; OTORHINOLARYNGOLOGY
