Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 李川军教授 (病理解剖及细胞学系) |
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
| 梁承晖教授 (肿瘤学系) |
| 张兆恬教授 (外科学系) |
| 罗国炜教授 (病理解剖及细胞学系) |
全文
| 没有全文档案提供 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/153WOS source URL
其它资讯
摘要We have recently reported that inactivation of the p16 gene by mutation and deletion is common in nasopharyngeal carcinoma (NPC). The present study demonstrates that hypermethylation of the 5' CpG island can serve as an alternative mechanism for inactivation of the p16 gene in this tumor, Using Southern blotting analysis and multiplex PCR, aberrant methylation of the 5' CpG island of the p16 gene was found in a NPC xenograft (xeno-666) and 6 (22%) of 27 primary tumors, but not in normal tissues of the nasopharynx, In the NPC xenograft (xeno-666) and its newly derived cell line (cell-666), both showing hypermethylation of the p16 gene, no p16 gene expression was found, After treatment with 5-aza-2'-deoxycytidine, reexpression of the p16 gene was detected in the cell line cell-666. These findings suggest that aberrant methylation of the 5' CpG island may participate in the transcriptional inactivation of the pld gene in NPC, The present results further support that the p16 gene is the critical target on chromosome 9p21 for inactivation during the development of this disease.
着者Lo KW, Cheung ST, Leung SF, vanHasselt A, Tsang YS, Mak KF, Chung YF, Woo JKS, Lee JCK, Huang DP
期刊名称Cancer Research
出版年份1996
月份6
日期15
卷号56
期次12
出版社AMER ASSOC CANCER RESEARCH
页次2721 - 2725
国际标準期刊号0008-5472
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1538-7445
语言英式英语
Web of Science 学科类别Oncology; ONCOLOGY
