Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 李川军教授 (病理解剖及细胞学系) |
| 梁承晖教授 (肿瘤学系) |
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
| 罗国炜教授 (病理解剖及细胞学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/123WOS source URL
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摘要Using 21 microsatellite polymorphic markers spanning both p and q arms, we have performed detailed deletion mapping on chromosome 9 in 18 primary nasopharyngeal carcinomas. All 18 tumors were informative at multiple loci. Eleven of the 18 cases (61%) demonstrated allelic deletion of chromosome 9. Among these 11, 6 cases are likely to be tumors with monosomy of chromosome 9. The other 5 cases demonstrated partial deletion by showing multiple areas of allelic loss. In one of the 5 cases, a homozygous deletion region was identified which includes D9S126, D9S171, and IFNA loci at 9p21-22, situated between loci D9S161 (9p21) and D9S162 (9p21-22). The presence of a homozygous deletion strongly suggests the presence of tumor suppressor gene(s) involved in the tumorigenesis of nasopharyngeal carcinoma. The same region has been reported to include some potential tumor suppressor gene loci in other cancers. This is the first reported finding of frequent genetic loss observed on chromosome 9 in nasopharyngeal carcinomas in addition to allelic loss on chromosome 3p at specific regions. Our results suggest that tumorigenesis and progression of nasopharyngeal carcinomas, like other solid tumors, involves multiple genetic changes associated with the inactivation of tumor suppressor genes.
着者HUANG DP, LO KW, VANHASSELT CA, WOO JKS, CHOI PHK, LEUNG SF, CHEUNG ST, CAIRNS P, SIDRANSKY D, LEE JCK
期刊名称Cancer Research
出版年份1994
月份8
日期1
卷号54
期次15
出版社AMER ASSOC CANCER RESEARCH
页次4003 - 4006
国际标準期刊号0008-5472
电子国际标準期刊号1538-7445
语言英式英语
Web of Science 学科类别Oncology; ONCOLOGY
