Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 尹怀信教授 (耳鼻咽喉-头颈外科学系) |
| 李川军教授 (病理解剖及细胞学系) |
| 梁承晖教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.3109/00016489409126025 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/52WOS source URL
其它资讯
摘要Forty-one paraffin embedded specimens of primary nasopharyngeal carcinoma (NPC) were examined to investigate the expression of c-myc and ras oncogenes. Sections were stained with the monoclonal antibodies myc 1-9E10 or ras Y13-259 and binding was detected using the ABC method. The intensity of staining for each tumour was assessed as nil, moderate or intense. The results indicated that 9 (22%) had intense staining for the c-myc oncogene, 28 (68%) had moderate staining and only 4 (10%) showed no staining. For the ras oncogene, 8 (19%) had intense staining, 22 (54%) moderate staining and 11 (27%) showed no staining. The patient's clinical data indicated no correlation between the expression of either c-myc or ras p21 and age, sex, smoking, tumour stage, antibody titre to EBV, or family history. No correlation was found between ras p21 expression and survival; however, overexpression of the c-myc oncogene correlated with a poor prognosis (p < 0.05). This study is consistent with investigations demonstrating that c-myc expression correlates with poor survival in head and neck tumours.
着者PORTER MJ, FIELD JK, LEUNG SF, LO D, LEE JCK, SPANDIDOS DA, VANHASSELT CA
期刊名称ACTA OTO-LARYNGOLOGICA
出版年份1994
月份1
日期1
卷号114
期次1
出版社SCANDINAVIAN UNIVERSITY PRESS
页次105 - 109
国际标準期刊号0001-6489
语言英式英语
关键词HEAD AND NECK CARCINOMA; SURVIVAL
Web of Science 学科类别Otorhinolaryngology; OTORHINOLARYNGOLOGY
