Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 欧志传先生 (肿瘤学系) |
| 陈德章教授 (肿瘤学系) |
| 陈明乐博士 (肿瘤学系) |
| 马碧如教授 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.3892/ol.2016.5321 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
其它资讯
摘要Although the Notch pathway has been reported to be activated in colorectal cancer (CRC), limited information is available regarding the expression and role of its ligand, Jagged 2 (JAG2), in CRC. Using immunohistochemistry, the present study demonstrated that JAG2 protein expression may be detected in up to 95% of CRC cases and is 3-fold upregulated in tumor cells compared to surrounding normal tissues. This finding suggests that JAG2 may have a role in the tumorigenicity of CRC. To further investigate the cellular functions of JAG2 expression in CRC, two different small interfering RNAs (siRNAs) were used to downregulate JAG2 expression in CRC cell lines (HCT116, DLD-1 and HT-29). The results indicated that JAG2 knockdown inhibits the motility and invasiveness of CRC cell lines without significantly affecting cell proliferation. These findings implicate JAG2 in promoting aggressiveness of CRC, and lay the foundation for its future development as a therapeutic target for the treatment of CRC.
出版社接受日期27.http://aims.cuhk.edu.hk/converis/portal/Publication/06.2http://aims.cuhk.edu.hk/converis/portal/Publication/016
着者Wan He, Charles Ming Lok Chan, Sze Chuen Cesar Wong, Thomas Chi Chuen Au, Wing Shan Ho, Amanda Kit Ching Chan, Andrew Sai Kit Chan, Brigette Buig Yue Ma, Anthony Tak Cheung Chan
期刊名称ONCOLOGY LETTERS
详细描述Epub 2http://aims.cuhk.edu.hk/converis/portal/Publication/016 Oct 26
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/016
月份12
卷号12
期次6
出版社[Athens : Spandidos Publications
出版地Greece
页次5193 - 5198
国际标準期刊号1792-1http://aims.cuhk.edu.hk/converis/portal/Publication/074
电子国际标準期刊号1792-1http://aims.cuhk.edu.hk/converis/portal/Publication/082
语言英式英语
关键词Jagged 2, Notch, colorectal cancer, invasion, migration
