Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 罗珮莹女士 (中医中药研究所) |
| 杜家辉教授 (病理解剖及细胞学系) |
| 莫树锦教授 (肿瘤学系) |
| 陈永鸿教授 (病理解剖及细胞学系) |
| 周捷博士 (病理解剖及细胞学系) |
| 唐婉君女士 (病理解剖及细胞学系) |
| 周淑玲女士 (病理解剖及细胞学系) |
| 罗珮莹女士 (中医中药研究所) |
| 康伟教授 (病理解剖及细胞学系) |
| 龙伟明博士 (病理解剖及细胞学系) |
| 唐红文博士 (病理解剖及细胞学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1097/JTO.0b013e3182904e22 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/29WOS source URL
其它资讯
摘要Introduction: The echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) fusion gene has been identified as a potent oncogenic driver in non-small-cell lung cancer, in particular adenocarcinoma (ADC). It defines a unique subgroup of lung ADC, which may be responsive to ALK inhibitors. Detection of ALK rearrangement by fluorescence in situ hybridization (FISH) or reverse transcriptase polymerase chain reaction (RT-PCR) is considered to be the standard procedure, but each with its own limitation. We evaluated the practical usefulness of immunohistochemistry (IHC) to detect ALK expression as a reliable detection method of ALK rearrangement in lung ADC.
着者To KF, Tong JHM, Yeung KSF, Lung RWM, Law PPY, Chau SL, Kang W, Tong CYK, Chow C, Chan AWH, Leung LKS, Mok TSK
期刊名称Journal of Thoracic Oncology
出版年份2013
月份7
日期1
卷号8
期次7
出版社Lippincott, Williams & Wilkins
页次883 - 891
国际标準期刊号1556-0864
电子国际标準期刊号1556-1380
语言英式英语
关键词Anaplastic lymphoma kinase; Echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase; Fluorescence in situ hybridization; Fusion transcript; Immunohistochemistry; Lung adenocarcinoma
Web of Science 学科类别Oncology; ONCOLOGY; Respiratory System; RESPIRATORY SYSTEM
