Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 杨明明教授 (肿瘤学系) |
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| 没有全文档案提供 |
引用次数
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/0Scopus source URL
其它资讯
摘要Gastric cancer is the fourth commonest cancer worldwide, with nearly a million new patients being diagnosed with this disease per year, of whom 55% are in East Asia. Regrettably, despite the availability of potentially curative resection, between 5http://aims.cuhk.edu.hk/converis/portal/Publication/0 and 9http://aims.cuhk.edu.hk/converis/portal/Publication/0% of these patients die as a result of disease relapse. This article discusses systemic therapy for advanced gastric cancer, with a focus on cytotoxic chemotherapy and targeted therapy for unresectable, metastatic or recurrent disease. Older-generation cytotoxics entailed 5-fluorouracil, the platinum compound cisplatin, and anthracyclines (doxorubicin and epirubicin). In this disease setting, clinical trials have addressed the role of palliative chemotherapy versus best supportive care, as well as single agent versus combination chemotherapy. New cytotoxic agents that have been tested include oral fluoropyrimidines (capecitabine and S-1), other platinum derivatives (oxaliplatin), taxanes (docetaxel and paclitaxel) and irinotecan. Outcomes associated with various treatment regimens incorporating these newer agents and old-generation combination chemotherapy have been compared. The main biological agents that have been tested include those that act on 3 classes of molecular targets, namely human epidermal growth factor receptor 2, vascular endothelial growth factor, and epidermal growth factor receptor. ? 2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0 Hong Kong College of Radiologists.
着者Yeo W.
期刊名称Journal- Hong Kong College of Radiologists
详细描述13(Suppl).
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/01http://aims.cuhk.edu.hk/converis/portal/Publication/0
月份12
日期1
卷号13
期次3 SUPPL.
出版社Scientific Communications International Ltd.
出版地Hong Kong
页次25 - 28
国际标準期刊号1http://aims.cuhk.edu.hk/converis/portal/Publication/029-5http://aims.cuhk.edu.hk/converis/portal/Publication/097
语言英式英语
关键词Antineoplastic combined chemotherapy protocols, Neoplasm metastasis, Neoplasm recurrence, local, Stomach neoplasms, Treatment outcome
