Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 郑彦铭教授 (内科及药物治疗学系) |
| 赖宝山教授 (外科学系) |
| 郑彦铭教授 (内科及药物治疗学系) |
| 徐宗宪博士 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.ejmech.2010.08.038 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/5WOS source URL
其它资讯
摘要Following our previously reported pyridinyl phosphine oxides as antitumor agents, we targeted the commercially available C-2-axial chiral organophosphine ligand catalysts, such as 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP) 1 and 2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine (P-Phos) 2 as a convenient source for producing organophosphine oxides as antitumor leads. Their corresponding chiral and racemic bi-phosphine oxides 3 and 4 can be obtained easily through a simple oxidation step with hydrogen peroxide, and their antitumor activities towards human hepatocellular carcinoma Hep3B cell line were reported. We found out that compound 3 shows stronger antitumor activity than that of 4, where axial chirality cannot improve their activity. Further athymic nude mice Hep3B xenograft model demonstrates the attractive in vivo antitumor potential of 3. (C) 2010 Elsevier Masson SAS. All rights reserved.
着者Lam KH, Chui CH, Gambari R, Wong RSM, Cheng GYM, Lau FY, Lai PBS, Tong SW, Chan KW, Wong WY, Chan ASC, Tang JCO
期刊名称European Journal of Medicinal Chemistry
出版年份2010
月份11
日期1
卷号4http://aims.cuhk.edu.hk/converis/portal/Publication/5
期次11
出版社Elsevier
页次http://aims.cuhk.edu.hk/converis/portal/Publication/5http://aims.cuhk.edu.hk/converis/portal/Publication/527 - http://aims.cuhk.edu.hk/converis/portal/Publication/5http://aims.cuhk.edu.hk/converis/portal/Publication/530
国际标準期刊号0223-http://aims.cuhk.edu.hk/converis/portal/Publication/5234
电子国际标準期刊号1768-32http://aims.cuhk.edu.hk/converis/portal/Publication/54
语言英式英语
关键词Antitumor activity; Bi-functional organophosphine oxides; Hepatocellular carcinoma
Web of Science 学科类别Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy
