Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陶谦教授 (肿瘤学系) |
| 应颖博士 (肿瘤学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.4161/epi.4.5.9371 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/96WOS source URL
其它资讯
摘要Aberrant activation of the WNT/beta-catenin signaling pathway is frequently involved in a broad spectrum of human malignancies. Alternative to genetic deletions and point mutations, epigenetic inactivation of negative WNT regulators, through DNA methylation of promoter CpG islands and/or histone modification, leads to the activation or amplification of aberrant WNT/beta-catenin signaling. In this review, we summarized the contribution of epigenetic dysregulation of WNT/beta-catenin signaling to tumorigenesis and highlighted the importance of epigenetic identification of negative regulators of this pathway as putative tumor suppressors. The reversal of these silenced regulators may be developed as potential cancer therapeutics.
着者Ying Y, Tao Q
期刊名称Epigenetics
出版年份2009
月份7
日期1
卷号4
期次5
出版社LANDES BIOSCIENCE
页次307 - 312
国际标準期刊号1559-2294
电子国际标準期刊号1559-2308
语言英式英语
关键词beta-catenin; cancer; epigenetic; methylation; signaling; tumor suppressor; WNT
Web of Science 学科类别Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY
