Isolated tumor cells and circulating CK20 mRNA in pN0 colorectal cancer patients
Publication in refereed journal


香港中文大学研究人员 ( 现职)

黄思铨教授 (肿瘤学系)

陈德章教授 (肿瘤学系)

陈明乐博士 (肿瘤学系)

林茵仪女士 (肿瘤学系)

马碧如教授 (肿瘤学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1177/1066896907311901

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/5WOS source URL

其它资讯

摘要Micrometastases in lymph nodes and blood may provide important prognostic information. In this study, cytokeratin 20 (CK20) positive cells in lymph nodes and circulating CK20 mRNA were studied using http://aims.cuhk.edu.hk/converis/portal/Publication/57 paraffin-embedded lymph node specimens and blood from 24 patients with pN0 colorectal cancer (CRC), respectively. Results showed that 29 out of http://aims.cuhk.edu.hk/converis/portal/Publication/56 (http://aims.cuhk.edu.hk/converis/portal/Publication/52%) lymph node specimens had CK20-positive cells (range: 1-3http://aims.cuhk.edu.hk/converis/portal/Publication/5). Follow-up of the patients for 12 months indicated that 4 patients (7%) had CRC metastases to liver, lung, and bone. In addition, 8 out of 24 (33%) samples had at least 2-fold circulating CK20 mRNA expression higher than the pooled normal sample. This study provides evidence that CK20-positive cells were found in the lymph nodes and differentially expressed circulating CK20 mRNA was also detected in the blood from patients with pN0 CRC. Long-term follow-up is necessary to study their prognostic use in patients with nonmetastatic CRC.

着者Wong CSC, Cheung MT, Ma BBY, Hui EP, Chan ACL, Chan CK, Lee KC, Cheuk W, Lam MYY, Wong MCK, Chan CML, Chan JKC, Chan ATC
期刊名称INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
出版年份2008
月份4
日期1
卷号16
期次2
出版社SAGE Publications (UK and US)
页次119 - 126
国际标準期刊号1066-8969
语言英式英语

关键词CK20; CK20 mRNA; colorectal cancer patients; lymph nodes; pN0
Web of Science 学科类别Pathology; PATHOLOGY; Surgery; SURGERY