Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 区皓智教授 (影像及介入放射学系) |
| 陈德章教授 (肿瘤学系) |
| 梁承晖教授 (肿瘤学系) |
| 徐仲?教授 (赛马会公共卫生及基层医疗学院) |
| 马碧如教授 (肿瘤学系) |
| Professor Ann Dorothy KING (影像及介入放射学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1259/bjr/73751469 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/36WOS source URL
其它资讯
摘要The aim of this study was to determine whether the use of whole-body F-18-fluoro-2-deoxy-D-glucose (F-18-FDG) positron emission tomography (PET)/CT alters staging and management of nasopharyngeal carcinoma (NPC) when compared with current staging practice. 52 patients with Stage III-IV NPC without distant metastases on chest X-ray/CT, abdominal ultrasound or bone scan were recruited for the study. Whole-body F-18-FDG PET/CT and MRI of the head and neck were performed. The scans were compared for extent of the primary tumour (PT), cervical nodal metastases (CNM) and distant metastases (DM). Any discordance in results was assessed with respect to staging and impact on management. MRI and F-18-FDG PET/CT scans were discordant in 28 (54%) patients. There was discordance in the extent of PT at 28 sites; in all sites, MRI showed more extensive tumour involving the nasopharynx (n=8), skull base (n=14), brain (n=4) and orbit (n=2). There was also variation among the extent of CNM in four nodes of the retropharyngeal region, with the nodes being positive on MRI. F-18-FDG PET /CT did not identify any additional distant metastases but did identify a second primary tumour in the colon. The additional use of F-18-FDG PET/CT did not "up-stage" the overall stage or change management in any patient. in conclusion, there is discordance between MRI and F-18-FDG PET/CT, and the additional use of F-18-FDG PET/CT for the current assessment of NPC at diagnosis does not appear to be justified in this cohort of patients.
着者King AD, Ma BB, Yau YY, Zee B, Leung SF, Wong JKT, Kam MKM, Ahuja AT, Chan KTC
期刊名称British Journal of Radiology,British Journal of Radiology
详细描述2008 April.
出版年份2008
月份4
日期1
卷号81
期次964
出版社BRITISH INST RADIOLOGY
页次291 - 298
国际标準期刊号0007-1285
电子国际标準期刊号1748-880X
语言英式英语
Web of Science 学科类别Radiology, Nuclear Medicine & Medical Imaging; RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
