A framework for the molecular classification of circulating tumor markers
Publication in refereed journal


香港中文大学研究人员 ( 现职)

庄立信教授 (肿瘤学系)

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摘要New molecular biological technologies, especially polymerase chain reaction (PCR) and mass spectroscopy, have expanded the pool of molecular targets for cancer diagnosis, monitoring, and prognosis using plasma or serum as the substrate. In this review, a framework is described following the "life history" of a protein-starting with DNA [endogenous (nuclear or mitochondrial) or exogenous (viral)], followed by RNA [endogenous (cell-based or cell-free) or exogenous (viral)], and culminating in protein (either the native protein or the glycan portion of glycoproteins). Each of these levels provides unique opportunities to achieve specificity for cancer diagnosis.

着者Johnson PJ
会议名称2nd International Symposium on Circulating Nucleic Acids in Plasma or Serum held in conjunction with the 6th Annual Scientific Symposium of the Hong-Kong-Cancer-Institute
会议开始日20.02.2001
会议完结日21.02.2001
会议地点HONG KONG
期刊名称Annals of the New York Academy of Sciences
详细描述vol.945
出版年份2001
月份1
日期1
卷号945
出版社NEW YORK ACAD SCIENCES
页次http://aims.cuhk.edu.hk/converis/portal/Publication/8 - 21
国际标準书号1-57331-37http://aims.cuhk.edu.hk/converis/portal/Publication/8-5
国际标準期刊号0077-http://aims.cuhk.edu.hk/converis/portal/Publication/8923
电子国际标準期刊号1749-6632
语言英式英语

关键词cancer; molecular markers; plasma nucleic acids
Web of Science 学科类别Biochemistry & Molecular Biology; Multidisciplinary Sciences; Science & Technology - Other Topics