Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 刘允怡教授 (外科学系) |
| 庄立信教授 (肿瘤学系) |
| 彭心鸣小姐 (肿瘤学系) |
| 赖宝山教授 (外科学系) |
| 王昭春教授 (病理解剖及细胞学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/71WOS source URL
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摘要We sought to assess whether genetic abnormalities in hepatocellular carcinoma differed in geographic locations associated with different risk factors. Comparative genomic hybridization (CGH) was applied to the genome-wide chromosomal analysis in 83 tumor samples from four different geographic origins. Samples were obtained from regions that differed in aflatoxin exposure: China (Hong Kong with low aflatoxin exposure and Shanghai with moderate aflatoxin exposure), Japan, and the United States (negligible aflatoxin exposure). Cases from Hong Kong and Shanghai were all hepatitis B virus (HBV) related, those from Japan were hepatitis C virus related, and those from the United States were HBV negative. In parallel, the mutational pattern of the whole p53 gene (exons 1-11) was also investigated in these cases, CGH revealed a complex pattern of chromosomal gains and losses, with the commonest aberration in each geographic location being chromosome Iq copy number gain (38-60%), Shanghai cases displayed the highest number of total aberrations per sample,,vith significant copy losses on 4q (75%), 8p (70%), and 16q (65%). Hepatitis C virus-related samples from Japan had a characteristically high incidence of 11q13 gain. p53 mutation(s) was detected in 23% of Hong Kong cases, 40% of Shanghai, 31% of Japan, hut only 6% of the United States cases. The "aflatoxin-associated" codon 249 mutation was, however, identified only in samples from China (13% Hang Kong and 20% Shanghai), This finding, together with the highly aberrant pattern of genetic changes detected in the Shanghai series, is suggestive of the genotoxic effects of anatoxin being more broadly based. It is also likely that there is a synergistic effect of HBV infection and high aflatoxin exposure in promoting hepatocellular carcinoma development. It appears from our CGH study that individual risk factors are indeed associated with distinct genetic aberrations, although changes in Iq gain appear common to all.
着者Wong N, Lai P, Pang E, Fung LF, Zhong S, Wong V, Wang WP, Hayashi Y, Perlman E, Shao Y, Lau JWY, Johnson PJ
期刊名称Clinical Cancer Research
出版年份2000
月份10
日期1
卷号6
期次10
出版社AMER ASSOC CANCER RESEARCH
页次4000 - 4009
国际标準期刊号1078-0432
电子国际标準期刊号1557-3265
语言英式英语
Web of Science 学科类别Oncology; ONCOLOGY
