Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 梁承晖教授 (肿瘤学系) |
| 罗国炜教授 (病理解剖及细胞学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1002/(SICI)1097-0215(19991029)83:3<305::AID-IJC3>3.0.CO;2-D |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/38WOS source URL
其它资讯
摘要Nasopharyngeal carcinoma (NPC) is rare in most pacts of the world, but prevalent in Southern China. Although this disease poses a serious health problem in our population, the genetic alterations that lead to the development of NPC have yet to be defined. In a comparative genomic hybridization (CGH) study on NPC by our group, loss of the long arm of chromosome 13 has been identified as a frequent event. To investigate further the involvement of this genetic alteration in NPC tumorigenesis, we examined 31 primary NPC tumours by LOH analysis with a panel of 13 microsatellite polymorphic markers distributed along the long arm of chromosome 13. It was found that 19/31 tumours (60%) showed LOH for markers on chromosome 13q. The highest frequency of LOH was found at loci D13S133 (53.6%) on 13q14.3 and D13S796 (http://aims.cuhk.edu.hk/converis/portal/Publication/38.5%) on 13q32-34. Two distinct smallest deletion regions were delineated: the first region between D13S133 and D13S119 at 13q14.3-22, and the second region between D13S317 and D13S285 at 13q31-34. Our findings show that LOH of 13q is a common event in NPC and that at least 2 putative tumour-suppressor loci may be present on 13q. Mapping of the critical regions of these loci suggests that some candidate tumour-suppressor genes on 13q, other than Rb and BRCA2, may be involved in the development of NPC. (C) 1999 Wiley-Liss, Inc.
着者Tsang YS, Lo KW, Leung SF, Choi PHK, Fong Y, Lee JCK, Huang DP
期刊名称INTERNATIONAL JOURNAL OF CANCER
出版年份1999
月份10
日期29
卷号83
期次3
出版社WILEY-LISS
页次305 - 308
国际标準期刊号0020-7136
电子国际标準期刊号1097-0215
语言英式英语
Web of Science 学科类别Oncology; ONCOLOGY
