Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 潘伟生教授 (外科学系) |
| 吴浩强教授 (病理解剖及细胞学系) |
| 陈家贤博士 (病理解剖及细胞学系) |
| 李嘉慧博士 (药剂学院) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/0WOS source URL
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摘要While the predominant elderly and the pediatric glioblastomas have been extensively investigated, young adult glioblastomas were understudied. In this study, we sought to stratify young adult glioblastomas by BRAF, H3F3A and IDH1 mutations and examine the clinical relevance of the biomarkers. In 1http://aims.cuhk.edu.hk/converis/portal/Publication/07 glioblastomas aged from 17 to 35 years, mutually exclusive BRAF-V6http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0E (15%), H3F3A-K27M (15.9%), H3F3A G34R/ V (2.8%) and IDH1-R132H (16.8%) mutations were identifi ed in over half of the cases. EGFR amplifi cation and TERT p mutation were only detected in 3.7% and 8.4% in young adult glioblastomas, respectively. BRAF-V6http://aims.cuhk.edu.hk/converis/portal/Publication/0http://aims.cuhk.edu.hk/converis/portal/Publication/0E identifi ed a clinically favorable subset of glioblastomas with younger age, frequent CDKN2A homozygous deletion, and was more amendable to surgical resection. H3F3A-K27M mutated glioblastomas were tightly associated with midline locations and showed dismal prognosis. IDH1-R132H was associated with older age and favorable outcome. Interestingly, tumors with positive PDGFRA immunohistochemical expression exhibited poorer prognosis and identifi ed an aggressive subset of tumors among K27M mutated glioblastomas. Combining BRAF, H3F3A and IDH1 mutations allowed stratifi cation of young adult glioblastomas into four prognostic subgroups. In summary, our study demonstrates the clinical values of stratifying young adult glioblastomas with BRAF, H3F3A and IDH1 mutations, which has important implications in refi ning prognostic classifi cation of glioblastomas.
着者Zhang RQ, Shi ZF, Chen H, Chung NYF, Yin Z, Li KKW, Chan DTM, Poon WS, Wu JS, Zhou LF, Chan AKY, Mao Y, Ng HK
期刊名称Oncotarget
详细描述2http://aims.cuhk.edu.hk/converis/portal/Publication/016.
出版年份2http://aims.cuhk.edu.hk/converis/portal/Publication/016
月份1
日期26
卷号7
期次4
出版社IMPACT JOURNALS LLC
页次5http://aims.cuhk.edu.hk/converis/portal/Publication/03http://aims.cuhk.edu.hk/converis/portal/Publication/0 - 5http://aims.cuhk.edu.hk/converis/portal/Publication/041
国际标準期刊号1949-2553
语言英式英语
关键词BRAF; glioblastoma; H3F3A; IDH1; prognostication
Web of Science 学科类别Cell Biology; Oncology
