Intestinal absorption of Stemona alkaloids in a Caco-2 cell model
Publication in refereed journal


香港中文大学研究人员 ( 现职)

林革教授 (生物医学学院)

左中教授 (药剂学院)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1055/s-2005-916195

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/11WOS source URL

其它资讯

摘要The intestinal absorption of neotuberostemonine and neostenine, two major bioactive alkaloids of the commonly used antitussive traditional Chinese medicine Stemona tuberosa Lour, was investigated using a Caco-2 monolayer model. Both alkaloids exhibited a high absorptive permeability which was higher for neostenine [P-app(AB) = 12.03 +/- 1.14 x 10(-6) cm/s] than for neotuberostemonine [P-app(AB) = 9.27 +/- 0.79 x 10(-6) cm/s], indicating that they are likely to be well absorbed and orally active. Furthermore, both alkaloids were identified to be the substrates of P-glycoprotein and have a transport preference from the basolateral to apical direction with efflux ratios between 2 and 3. Cyclosporin A dose-dependently inhibited the secretory permeability of these alkaloids and abolished their active efflux transport.

着者Leung PHH, Zhang L, Zuo Z, Lin G
期刊名称Planta Medica
出版年份2006
月份2
日期1
卷号72
期次3
出版社GEORG THIEME VERLAG KG
页次2http://aims.cuhk.edu.hk/converis/portal/Publication/11 - 216
国际标準期刊号0032-0943
电子国际标準期刊号1439-0221
语言英式英语

关键词Caco-2 cell model; neostenine; neotuberostemonine; Stemona alkaloids; Stemona tuberosa
Web of Science 学科类别Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY; Plant Sciences; PLANT SCIENCES