Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 周柽森教授 (药剂学院) |
| 周喜林教授 (药剂学院) |
| 汤宁信教授 |
| 印绮平教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/S0378-5173(01)00712-8 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/18WOS source URL
其它资讯
摘要The pharmacokinetics of acetaminophen have been well studied in different populations, especially in Caucasians. However, limited studies on acetaminophen pharmacokinetics have been conducted in the native Chinese and few such data have been reported in the English language literature. Previous published studies suggested that environmental and genetic factors may cause inter-individual difference in acetaminophen disposition, thus we investigated the pharmacokinetics of acetaminophen in Hong Kong Chinese subjects. A single 500 mg oral dose of acetaminophen was administered to 12 healthy male Chinese subjects under fasting conditions. Multiple blood samples were obtained after drug administration. Plasma acetaminophen concentrations were determined using HPLC, and its main pharmacokinetic parameters were generated. In comparison to other published data, acetaminophen half-life was considerably longer (15-62%), and oral clearance was lower (16-56%) in Hong Kong Chinese as compared to Australian Chinese, Caucasians (USA, UK, Australia), and subjects from Pakistan, Denmark, Spain and South Africa. Similarities however were found in the pharmacokinetic parameters between Hong Kong Chinese and Mainland Chinese subjects. The observed pharmacokinetic parameters of acetaminophen in Hong Kong Chinese subjects may be different from other ethnic populations. Further studies are needed to verify this hypothesis. (C) 2001 Elsevier Science B.V. All rights reserved.
着者Yin OQP, Tomlinson B, Chow AHL, Chow MSS
期刊名称International Journal of Pharmaceutics
出版年份2001
月份7
日期17
卷号222
期次2
出版社ELSEVIER SCIENCE BV
页次305 - 308
国际标準期刊号0378-5173
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1873-3476
语言英式英语
关键词acetaminophen; ethnic difference; pharmacokinetics
Web of Science 学科类别Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
