Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 周喜林教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.3109/03639049609042001 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/14WOS source URL
其它资讯
摘要Spherical agglomeration of a number of chemical and pharmaceutical powders was effected in a stirred liquid mixture using the navel technique developed by Kawashima and Gapes, with modifications. The compounds were first classified into four groups on the basis of their solubilities in the liquid systems employed and, accordingly, agglomerated using appropriately developed methods. Each powdered material was first suspended in a liquid medium (external phase) and agglomeration was achieved by addition of a relatively small amount of ''bridging'' liquid (internal phase) which was immiscible with the (external) dispersion medium. The resulting spherical agglomerates were examined for size, binding strength, and surface topography. It appeared that a considerable number of the suspended particles initially underwent partial dissolution in the bridging liquid. The dissolved portion then collected the undissolved powder into spherical agglomerates under the influence of continuous stirring. Based on the trials and observations on a number of materials ranging from inorganics to organics, the general guidelines for spherical agglomeration of pharmaceutical powders were established. It is hoped that these guidelines will aid the application of this technique in the pharmaceutical and allied industries.
着者Chow AHL, Leung MWM
期刊名称Drug Development and Industrial Pharmacy
出版年份1996
月份1
日期1
卷号22
期次4
出版社MARCEL DEKKER INC
页次357 - 371
国际标準期刊号0363-9045
电子国际标準期刊号1520-5762
语言英式英语
Web of Science 学科类别Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
