Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 韦妙宜教授 (那打素护理学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1155/2013/358902 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/13WOS source URL
其它资讯
摘要Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and ranks third in the leading causes of cancer patient's death. Cancer stem cells (HSCs), also known as tumor-initiating cells, have been reported in multiple subtypes of HCC and are considered as the master regulators of HCC initiation, chemotherapy drug resistance, tumor metastasis, and progression. In spite of their clinical importance, the detailed mechanism about how HSCs are intricately regulated in the molecular level remains elusive. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, has been demonstrated to serve as a vital player in modulating a number of biological activities ranging from embryogenesis to programmed cell death as well as the maintenance of HSCs. In this review, we synthesize these latest findings of miRNA regulation of HSCs and try to elucidate their mechanistic roles in orchestrating cellular equilibrium. This recent progress underlies the functional role of miRNA in cellular transformation of liver cancer, which has largely extended our knowledge how HSCs are controlled by miRNA network, and in the development of novel miRNA-based anticancer therapies specifically targeting HSCs in the coming future.
着者Qi W, Liang WC, Waye MM, Jiang HQ
期刊名称BioMed Research International
详细描述To ORKTS: doi: 10.1155/20http://aims.cuhk.edu.hk/converis/portal/Publication/13/358902
出版年份20http://aims.cuhk.edu.hk/converis/portal/Publication/13
月份1
日期1
出版社Hindawi Publishing Corporation
国际标準期刊号2314-6http://aims.cuhk.edu.hk/converis/portal/Publication/133
电子国际标準期刊号2314-6141
语言英式英语
Web of Science 学科类别Biotechnology & Applied Microbiology; Medicine, Research & Experimental; Research & Experimental Medicine
