Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 吴楚枫先生 (生物医学学院) |
| 徐国荣教授 (生物医学学院) |
| 赖宝山教授 (外科学系) |
| 伍儒敬博士 (生物医学学院) |
| 冯国培教授 (生物医学学院) |
| 陈月华博士 (那打素护理学院) |
| 李家亮博士 (生物医学学院) |
| 吕伟欣教授 (生物医学学院) |
| 吴国城博士 (生物医学学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.canlet.2011.02.001 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/17WOS source URL
其它资讯
摘要FHL2 displays tumor promoting or tumor suppressing activities depending on the types of tumor cells. In this study, we demonstrated that FHL2 overexpression inhibits the proliferation of human HCC cells Hep3B through cell cycle regulation by decreasing cyclin D1 expression while increasing the expressions of p21 and p27. FHL2 overexpression also inhibits migration and invasion of Hep3B cells through the regulation of epithelial-mesenchymal transition. Surprisingly, we also demonstrated an antiapoptotic function for FHL2 overexpression with increased resistance to doxorubicin-induced apoptosis, which indicates the separation of anti-proliferative and anti-apoptotic role of FHL2. Taken together, our results indicate FHL2 could exert anti-apoptotic effect independent of tumor growth suppression. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
着者Ng CF, Ng PKS, Lui VWY, Li JL, Chan JYW, Fung KP, Ng YK, Lai PBS, Tsui SKW
期刊名称Cancer Letters
出版年份2011
月份5
日期28
卷号304
期次2
出版社Elsevier
页次97 - 106
国际标準期刊号0304-3835
电子国际标準期刊号1872-7980
语言英式英语
关键词Apoptosis; FHL2; Liver cancer; Proliferation
Web of Science 学科类别Oncology; ONCOLOGY
