Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈基湘教授 (微生物学系) |
| 沈祖尧教授 (内科及药物治疗学系) |
| 朱妙婷女士 (微生物学系) |
| 张丽群博士 (那打素护理学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1086/507044 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/6WOS source URL
其它资讯
摘要The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is reported to have deletions of various sizes. Recently, the large 38http://aims.cuhk.edu.hk/converis/portal/Publication/6-nucleotide deletion (L38http://aims.cuhk.edu.hk/converis/portal/Publication/6del) comprising nucleotide positions 2771928104 and spanning open reading frames 9-11 has been reported in the genomes of some human isolates from Hong Kong. In this study, archived specimens from 71 patients with SARS who were admitted to the New Territory East Cluster Hospitals in Hong Kong were analyzed to determine whether the L38http://aims.cuhk.edu.hk/converis/portal/Publication/6del variant of SARS-CoV was present. There was no clear relationship between the presence of the L38http://aims.cuhk.edu.hk/converis/portal/Publication/6del variant and SARS clinical severity as defined either by the need for intensive-care therapy and/or ventilation or by death. One patient had evidence of both the L38http://aims.cuhk.edu.hk/converis/portal/Publication/6del variant and the wild-type variant in the same clinical specimen, supporting the idea that SARS-CoV exists as a quasispecies in some patients, although the clinical significance of these quasispecies remains unclear.
着者Tang JW, Cheung JLK, Chu IMT, Sung JJY, Peiris M, Chan PKS
期刊名称Journal of Infectious Diseases
出版年份200http://aims.cuhk.edu.hk/converis/portal/Publication/6
月份9
日期15
卷号194
期次http://aims.cuhk.edu.hk/converis/portal/Publication/6
出版社UNIV CHICAGO PRESS
页次808 - 813
国际标準期刊号0022-1899
电子国际标準期刊号1537-http://aims.cuhk.edu.hk/converis/portal/Publication/6http://aims.cuhk.edu.hk/converis/portal/Publication/613
语言英式英语
Web of Science 学科类别Immunology; IMMUNOLOGY; Infectious Diseases; INFECTIOUS DISEASES; Microbiology; MICROBIOLOGY
