Genetic variation of glycoproteins B and H of human herpesvirus 7 in Hong Kong
Publication in refereed journal


香港中文大学研究人员 ( 现职)

张丽群博士 (那打素护理学院)

吴景祥医生 (微生物学系)

戚其威教授 (儿科学系)

李志光教授 (儿科学系)

陈基湘教授 (微生物学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1002/jmv.10496

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/1WOS source URL

其它资讯

摘要Glycoprotein B (gB) and glycoprotein H (gH) of human herpesvirus 7 (HHV-7) are believed to play an important role in virus entry and as targets for host immune response. This study examined the genetic diversity of these glycoproteins among 90 HHV-7 isolates collected from different individuals in Hong Kong. Overall, both the gB and gH genes were found to be highly conserved. Nucleotide polymorphism was detected only at four positions of the gB-encoding region, and all of these were synonymous substitutions. Most (97.8%) Hong Kong isolates were of gB allele group C. Two isolates collected from a Pakistani family showed a novel sequence pattern that did not match known gB allele groups. This sequence pattern was detected consistently from serial samples collected from the same individual, indicating a stable genetic entity. The gH-encoding region exhibited nucleotide polymorphism at six positions. Three of these were nonsynonymous substitutions (codon 27http://aims.cuhk.edu.hk/converis/portal/Publication/1 Lys-->Gln, codon 308 Gly-->Glu, codon 397 Asn-->Tyr). Most (84.4%) Hong Kong isolates were of the gH allele group B, and all others were of the gH allele group C. These data indicate the possibility of using gB or gH alleles as markers for studying world-wide population movements and genetics.

着者Chan PKS, Li CK, Chik KW, Shing MMK, Lee V, Ng KC, Lam CW, Cheung JLK, Cheng AF
期刊名称Journal of Medical Virology
出版年份2003
月份http://aims.cuhk.edu.hk/converis/portal/Publication/1http://aims.cuhk.edu.hk/converis/portal/Publication/1
日期http://aims.cuhk.edu.hk/converis/portal/Publication/1
卷号7http://aims.cuhk.edu.hk/converis/portal/Publication/1
期次3
出版社WILEY-LISS
页次429 - 433
国际标準期刊号0http://aims.cuhk.edu.hk/converis/portal/Publication/146-66http://aims.cuhk.edu.hk/converis/portal/Publication/15
电子国际标準期刊号http://aims.cuhk.edu.hk/converis/portal/Publication/1096-907http://aims.cuhk.edu.hk/converis/portal/Publication/1
语言英式英语

关键词allele; beta-herpesvirus; Chinese; polymorphism
Web of Science 学科类别Virology; VIROLOGY