Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 韦妙宜教授 (那打素护理学院) |
| 林国念博士 (精神科学系) |
| 李德诚教授 (精神科学系) |
| 荣润国教授 (精神科学系) |
| 赵凤琴教授 (精神科学系) |
| 周乐怡医生 (精神科学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/75WOS source URL
其它资讯
摘要Background: The cytochrome P450 CYP2D6 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as tricyclic antidepressants and neuroleptics, Genetic polymorphism of the CYP2D6 gene is responsible for pronounced interindividual and interracial differences in the metabolism of these drugs. The CYP2D6*10 allele and its variants are the most frequent alleles found in Orientals, and they are responsible for diminished debrisoquine 4-hydroxylase activity because of the presence of a C(188)-->T mutation in exon 1,
着者Garcia-Barcelo M, Chow LY, Chiu HFK, Wing YK, Lee DTS, Lam KL, Waye MMY
期刊名称Clinical Chemistry
出版年份2000
月份1
日期1
卷号46
期次1
出版社AMER ASSOC CLINICAL CHEMISTRY
页次18 - 23
国际标準期刊号0009-9147
电子国际标準期刊号1530-8561
语言英式英语
Web of Science 学科类别Medical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY
