Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 吴景祥医生 (微生物学系) |
| 张丽群博士 (那打素护理学院) |
| 吴浩强教授 (病理解剖及细胞学系) |
| 陈基湘教授 (微生物学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1002/1096-9071(200011)62:3<345::AID-JMV6>3.0.CO;2-# |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/16WOS source URL
其它资讯
摘要Although it has been recognised that human herpesvirus 7 (HHV-7) establishes latent infection in CD4(+) T lymphocytes and productive infection in salivary glands, recent data suggest that its in vivo tropism may be more widespread. In this study, the prevalence and distribution of HHV-7 in brain tissues of 30 consecutive post-mortems were examined by nested polymerase chain reaction. For each postmortem, 10 fresh autopsy tissue samples were collected respectively from the cerebellum, frontal, temporal, parietal, and occipital robes of both cerebral hemispheres. These patients were aged from 20-95 years (mean = 61.4, SD = 20.2) with a male:female ratio of 2:1. Three patients died of intracranial haemorrhage, the others died of causes unrelated to the central nervous system. Overall, 5% (15/300) of the brain tissue samples were positive for HHV-7 DNA. The positive rates with respect to anatomical positions were similar (0-3/30). When analysed by patient, 36.7% (11/30) were HHV-7 DNA positive. The viral DNA-positive and -negative groups did not show a significant difference in gender or age distribution. The majority (81.8%) of viral DNA-positive patients had HHV-7 DNA detected at only one anatomical position; only two patients had viral DNA detected simultaneously at three anatomical sites. These results suggest that HHV-7 persists in brain tissues of a substantial proportion of the adult population, and in most individuals, its distribution is probably confined to one site rather than pervasive. Further studies to elucidate the role of this ubiquitous virus in neuropathology are warranted. J. Med. Virol. 62: 345-348, 2000. (C) 2000 Wiley-Liss, Inc.
着者Chan PKS, Ng HK, Cheung JLK, Ng KC, Cheng AF
期刊名称Journal of Medical Virology
出版年份2000
月份11
日期1
卷号62
期次3
出版社WILEY-LISS
页次345 - 348
国际标準期刊号0146-6615
电子国际标準期刊号1096-9071
语言英式英语
关键词beta herpesvirus; central nervous system; latency; neuroinvasion; persistence; tropism
Web of Science 学科类别Virology; VIROLOGY
