Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 孙德生教授 (医学院) |
| 余卓文教授 (内科及药物治疗学系) |
| 林逸贤教授 (内科及药物治疗学系) |
| 孙德生教授 (医学院) |
| 张庆教授 (内科及药物治疗学系) |
| 房芳教授 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/j.1540-8159.2012.03403.x |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/6WOS source URL
其它资讯
摘要Background : The acute effects of right ventricular apical (RVA) pacing on left atrial (LA) function in patients with normal ejection fraction are not clear. Methods : A total of 94 patients (age http://aims.cuhk.edu.hk/converis/portal/Publication/68.1 +/- 11.1 years, 2http://aims.cuhk.edu.hk/converis/portal/Publication/6 men) with implanted RVA-based dual-chamber pacemakers were recruited into this study. Patients who were pacemaker-dependent, in persistent atrial fibrillation or left ventricular ejection fraction <45% were excluded. Echocardiography (iE33, Philips, Andover, MA, USA) was performed during intrinsic ventricular conduction (V-sense) and RVA pacing (V-pace) with 15 minutes between switching modes. The total maximal LA volume (LAVmax), preatrial contraction volume (LAVpre), and minimal volume (LAVmin) were assessed by area-length method. Peak systolic, early diastolic, and peak late diastolic (atrial contractile) velocity (Sm-la, Em-la, and Am-la) and strain (?s-la, ?e-la, and ?a-la) were measured by color-coded tissue Doppler imaging (TDI) in four mid-LA walls at apical four- and two-chamber views. Results : During V-pace, LA volumes increased significantly compared with V-sense (LAVmax: 52.0 +/- 18.8 vs 55.2 +/- 21.1 mL, P = 0.005; LAVpre: 39.8 +/- 1http://aims.cuhk.edu.hk/converis/portal/Publication/6.4 vs 41.3 +/- 1http://aims.cuhk.edu.hk/converis/portal/Publication/6.http://aims.cuhk.edu.hk/converis/portal/Publication/6 mL, P = 0.014; LAVmin: 27.4 +/- 14.0 vs 29.1 +/- 15.1 mL, P = 0.001). TDI parameters showed significant reduction in Sm-la and Em-la. Furthermore, ?s-la, ?e-la, and ?a-la decreased significantly, especially in patients with preexisting diastolic dysfunction (all P < 0.01). Conclusions: RVA pacing acutely induced LA enlargement and impaired atrial contractility. Patients with preexisting diastolic dysfunction may be more vulnerable to develop LA dysfunction and remodeling after acute RVA pacing. (PACE 2011;XX:17)
着者Xie JM, Fang F, Zhang Q, Sanderson JE, Chan JYS, Lam YY, Yu CM
期刊名称Pacing and Clinical Electrophysiology
出版年份2012
月份7
日期1
卷号35
期次7
出版社WILEY-BLACKWELL
页次85http://aims.cuhk.edu.hk/converis/portal/Publication/6 - 8http://aims.cuhk.edu.hk/converis/portal/Publication/62
国际标準期刊号0147-8389
语言英式英语
关键词atrial; bradycardia; cardiac remodeling; echocardiography; pacemakers
Web of Science 学科类别Cardiac & Cardiovascular Systems; CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiovascular System & Cardiology; Engineering; Engineering, Biomedical; ENGINEERING, BIOMEDICAL
