Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 孙德生教授 (医学院) |
| 叶维国教授 (内科及药物治疗学系) |
| 余卓文教授 (内科及药物治疗学系) |
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| 数位物件识别号 (DOI) ○○@http://aims.cuhk.edu.hk/converis/portal/Publication/5$@○○ |
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摘要Heart failure is a serious disorder associated with substantial morbidity and mortality. Approximately 1http://aims.cuhk.edu.hk/converis/portal/Publication/5-30% patients with systolic heart failure are in atrial fibrillation and the proportion increases with severity of heart failure. Patients with heart failure and atrial fibrillation have worse outcome than those in sinus rhythm. Beta-blockers, together with angiotensin-converting enzymes inhibitors, are the standard therapy in patients with chronic heart failure. Retrospective studies have suggested that despite the improvement in left ventricular systolic function after treatment with beta-blockers, the exercise capacity and symptoms in those heart failure patients with atrial fibrillation was not improved as much as those in sinus rhythm. Moreover, the use of bisoprolol in the Cardiac Insufficiency Bisoprolol Study II, unlike those in sinus rhythm, failed to produce any survival benefit in patients with poor systolic function and atrial fibrillation. It seems that those patients with heart failure and atrial fibrillation may have different response to beta-blocker therapy. Prospective trials to clarify the impact of beta-blocker therapy and the optimal therapeutic strategy in this high-risk group of patients are warranted. ? 2003 Kluwer Academic Publishers.
着者Fung J.W.H., Yu C.M., Kum L.C.C., Yip G.W.K., Sanderson J.E.
期刊名称Cardiac Electrophysiology Review
出版年份2003
月份9
日期1
卷号7
期次3
出版社Kluwer Academic Publishers
出版地Netherlands
页次236 - 242
国际标準期刊号138http://aims.cuhk.edu.hk/converis/portal/Publication/5-2264
语言英式英语
关键词Atrial fibrillation, Beta-blocker, Heart failure
