Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 刘德辉教授 (赛马会公共卫生及基层医疗学院) |
| 宋银子教授 (医学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1136/adc.69.4.440 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/21WOS source URL
其它资讯
摘要A prospective randomised, double blind, controlled trial was conducted in 52 infants to determine whether recombinant interferon alfa-2a (INF-alpha-2a) would reduce the morbidity of acute bronchiolitis and the respiratory syncytial virus shedding time. All infants had a positive direct antigen immunofluorescence test for respiratory syncytial virus. INF-alpha-2a (50 000 IU/kg/day) or placebo was administered by daily intramuscular injection for three consecutive days. Sixteen infants received INF-alpha-2a and 36 received placebo treatment. The two groups were similar in demographic characteristics and initial oxygenation. The treatment group, however, had a significantly higher overall score for severity of illness at the start of treatment. More rapid drop of the clinical score was observed in the INF-alpha-2a group after treatment in the first three days and the two groups had similar clinical severity by day 3. There was no significant difference of the duration of viral shedding in the two groups. In conclusion, the overall clinical improvement was greater in the treatment group over the first three days, but the duration of viral shedding was not altered.
着者SUNG RYT, YIN J, OPPENHEIMER SJ, TAM JS, LAU J
期刊名称ARCHIVES OF DISEASE IN CHILDHOOD
出版年份1993
月份10
日期1
卷号69
期次4
出版社BRITISH MED JOURNAL PUBL GROUP
页次440 - 442
国际标準期刊号0003-9888
电子国际标準期刊号1468-2044
语言英式英语
Web of Science 学科类别Pediatrics; PEDIATRICS
