Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 叶碧瑶教授田奇博士 (微生物学系) |
| Professor Gavin Matthew JOYNT (麻醉及深切治疗学系) |
| Professor Charles David GOMERSALL (麻醉及深切治疗学系) |
| (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1128/AAC.00858-07 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/21WOS source URL
其它资讯
摘要We used an in vitro model of continuous venovenous hemofiltration (CVVH) to characterize amikacin adsorption by polyacrylonitrile (PAN) and polyamide filters. A blood-crystalloid mixture dosed with amikacin was pumped from a reservoir through a hemofiltration circuit and back to the reservoir. All ultrafiltrate was also returned to the reservoir. The level of adsorption was calculated from the fall in the amikacin concentration. The dose and the initial concentration of amikacin were varied, as were the pH, the type of hemofilter, and the hemofilter surface area. The reversibility of adsorption and the effect of repeated dosing were also studied. The level of adsorption by 0.6-m(2) PAN filters was significantly greater than that by 0.6-m2 polyamide filters. Adsorption was increased by increasing the dose of amikacin even when the initial concentration was unchanged. It was unaffected by the pH (pH 6.8 or 7.4) or the hemofilter surface area (0.6 m(2) or 0.9 m(2)). Repeated doses of amikacin resulted in further adsorption. In a saturation experiment, the maximum adsorptive capacity of 0.6-m(2) PAN hemofilters was at least 546.9 mg (range, 427.6 to 577.5 mg). The adsorption of amikacin by hemofilters is irreversible and was associated with the dose and the hemofilter material but not the hemofilter surface area. Close monitoring of peak amikacin levels should be considered for patients receiving CVVH with PAN hemofilters.
着者Tian Q, Gomersall CD, Ip M, Tan PE, Joynt GM, Choi GYS
期刊名称ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
出版年份2008
月份3
日期1
卷号52
期次3
出版社AMER SOC MICROBIOLOGY
页次1009 - 1013
国际标準期刊号0066-4804
电子国际标準期刊号1098-6596
语言英式英语
Web of Science 学科类别Microbiology; MICROBIOLOGY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY
