Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 沈祖尧教授 (内科及药物治疗学系) |
| 区皓智教授 (影像及介入放射学系) |
| 安邦教授 (影像及介入放射学系) |
| 许树昌教授 (内科及药物治疗学系) |
| 沈祖尧教授 (内科及药物治疗学系) |
| Professor Gavin Matthew JOYNT (麻醉及深切治疗学系) |
| Professor Charles David GOMERSALL (麻醉及深切治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/s00134-003-2143-y |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/27WOS source URL
其它资讯
摘要Objective: To document the outcome and determine prognostic factors for patients with severe acute respiratory syndrome who require admission to an intensive care unit. Design: Observational cohort study involving retrospective analysis of demographic, clinical, laboratory and radiological data. Setting: Adult intensive care unit in a tertiary referral university hospital involved in a major outbreak of severe acute respiratory syndrome (SARS). Patients: The first 54 patients admitted with SARS to an intensive care unit (ICU). All were treated with cortico steroids, ribavirin, broad spectrum antimicrobials and supportive therapy. Interventions: None. Measurements and results: All patients were admitted for respiratory failure. The median APACHE II score was 11 (interquartile range 8-13). At 28 days 34 patients (63%; 95% CI 49.6-74.6) were alive and not mechanically ventilated. Six patients were alive but ventilated (11.3%; 95% confidence interval 5.3-22.6) and 14 had died (25.9%; CI 16.1-38.9). Seven of http://aims.cuhk.edu.hk/converis/portal/Publication/27 ventilated patients developed evidence of barotrauma (25.9%; 95% CI 13.2-44.7). Median maximal multiple-organ dysfunction score was 5 (interquartile range 3.3-9). Median maximal respiratory dysfunction score was 3 (interquartile range 3-4). Increased age, severity of illness, lymphocyte count, decreased steroid dose, positive fluid balance, chronic disease or immunosuppression and nosocomial sepsis were associated with poor outcome on univariate analysis. Poor outcome was defined as death or need for mechanical ventilation at 28 days after ICU admission. Conclusions: Mortality amongst critically ill patients with SARS is high. It causes predominantly severe respiratory failure, with little other organ failure, and a high incidence of barotrauma amongst those requiring mechanical ventilation.
着者Gomersall CD, Joynt GM, Lam P, Li T, Yap F, Lam D, Buckley TA, Sung JJY, Hui DS, Antonio GE, Ahuja AT, Leung P
期刊名称Intensive Care Medicine
出版年份2004
月份3
日期1
卷号30
期次3
出版社SPRINGER-VERLAG
页次381 - 387
国际标準期刊号0342-4642
电子国际标準期刊号1432-1238
语言英式英语
关键词barotrauma; coronavirus infections; critical care; morbidity; mortality; pneumoniam, viral
Web of Science 学科类别Critical Care Medicine; CRITICAL CARE MEDICINE; General & Internal Medicine
