Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 陈德威教授 (麻醉及深切治疗学系) |
| Professor Tony GIN (麻醉及深切治疗学系) |
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| 数位物件识别号 (DOI) ○○@http://aims.cuhk.edu.hk/converis/portal/Publication/3$@○○ |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/3WOS source URL
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摘要Postpartum patients have not completely lost the weight gained during pregnancy. Drug dosing according to total body weight (TBW) can cause exaggerated effects and dosing by lean body mass (LBM) may provide a more consistent response despite the increased weight. We compared the duration of a rocuronium neuromuscular block in 22 women undergoing postpartum tubal ligation http://aims.cuhk.edu.hk/converis/portal/Publication/31-79 h after delivery, with that in 22 women undergoing gynecological surgery. Anesthesia was induced and maintained with propofol and alfentanil. Half of the patients in each of the Postpartum and Control groups received a bolus dose of rocuronium 0.6 mg/kg TBW and the remaining half received rocuronium 0.6 mg/kg LBM. Neuromuscular block was monitored by electromyography and the ulnar nerve was stimulated transcutaneously using a train-of-four pattern. When rocuronium was given by TBW, median (range) duration of neuromuscular block until 25% recovery of the first twitch response was longer in the Postpartum group, http://aims.cuhk.edu.hk/converis/portal/Publication/35.http://aims.cuhk.edu.hk/converis/portal/Publication/3 (29.7-48.7) min, compared with the Control group, 24.8 (21.5-28.6) min (P < 0.001). After dosing by LBM, the duration of block was similar between groups. The prolonged block with rocuronium in the Postpartum patients can be explained by relative drug overdose when dose calculation is based on their temporarily increased body weight.
着者Gin T, Chan MTV, Chan KL, Yuen PM
期刊名称Anesthesia and Analgesia
出版年份2002
月份http://aims.cuhk.edu.hk/converis/portal/Publication/3
日期1
卷号94
期次http://aims.cuhk.edu.hk/converis/portal/Publication/3
出版社LIPPINCOTT WILLIAMS & WILKINS
页次686 - 689
国际标準期刊号000http://aims.cuhk.edu.hk/converis/portal/Publication/3-2999
电子国际标準期刊号1526-7598
语言英式英语
Web of Science 学科类别Anesthesiology; ANESTHESIOLOGY
