5107, 5/F, Cheng Yick-chi Building
+852 3442-7797
+852 3442-0549
bhmyang@cityu.edu.hk
CityU Scholars
Lab Website
Cancer Biology • Microfluidic Technology • Nanomedicine

Prof. Yang obtained his PhD from University of Toronto and postdoctoral training in the Scripps Research Institute. He is currently the Vice President (Research and Technology) and Yeung Kin-Man Chair Professor of Biomedical Sciences in City University of Hong Kong, and the Director of the Biotech and Health Centre of City University Shenzhen Research Institute. The research interest of Yang’s group focuses on development of biochip technology and nanotechnology for molecular diagnostics and therapeutic applications. Prof. Yang has published over 280 peer-reviewed scientific papers and received 33 USA/China patents. He has delivered more than 100 invited lectures in international conferences and universities, and trained 38 PhD graduates and numerous postdoctoral fellows in his laboratory. He has been awarded the Chunhui Scholar Award by the Ministry of Education in 2003, the K. C. Wong Foundation Award in 2004, the Shenzhen Science and Technology Innovation Award in 2006, the Hong Kong Technological Achievement Grand Award in 2007, the Natural Science Award by the Ministry of Education in 2015, the Wuxi AppTech Life Science and Chemistry Award in 2016, and the Gold Medal of Geneva International Inventions Expo in 2019. He is a member of Hong Kong SAR government’s Research Grants Council, and serves as panel members for the Health and Medical Research Fund and the Innovation and Technology Fund of Hong Kong. He also serves as vice chairman of the Hong Kong Biotechnology Association, a council member of the Division of Nanobiotechnology, Biosensors and Biochips of the Asia Federation of Biotechnology, and a Mentor of Hong Kong X-Tech Platform. He has co-founded several biotech companies including Genetel, Prenetics, and Cellomics.
Media PublicityMicrofluidic Technology for Accelerated Screening of Anti-Cancer Drugs (CityU Research Story)
杨梦苏：做好癌症最早期的侦察兵 (《今日中国》)
专访香港城市大学教授杨梦苏：校园创业达人 引领香港生物科技 (药明康德传媒)
生物科技与健康 – 从人类基因组到精准医疗 (City Seminar)
Interview with PHARMA Boardroom
杨梦苏：倡社会塑造「创科氛围」 (《星岛日报》)
城大副校长杨梦苏：学生不要害怕失败 (《星岛日报》)
杨梦苏：城大五亿培育300初创 (《星岛日报》)
Representative PublicationsMicrofluidics for Cell AnalysisMicrodissected ‘cuboids’ for microfluidic drug testing of intact tissues, Lab on a Chip, 2021, 21, 122-142.
Single cell target gene mutation analysis by arc-edge-channel monolithic valve microfluidic cell isolation and locked nucleic acid based PCR detection, Sensors and Actuators B: Chemical, 2019, 293, 224-234.
Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007-2017), Analytica Chimica Acta, 2018, 1044, 29-65.
Electrotaxis of cancer stem cells is associated with both activation of stretch-activated cation channels and internal calcium release, Bioelectrochemistry, 2018, 124, 80-92.
Cell migration microfluidics for electrotaxis-based heterogeneity study of lung cancer cells, Biosensors and Bioelectronics, 2017, 89, 837-845.
Microfluidic platform for studying chemotaxis of adhesive cells revealed a gradient-dependent migration and acceleration of cancer stem cells, Analytical Chemistry, 2015, 87(14), 7098-7108.
A microfluidic linear node array for the study of protein-ligand interaction, Lab Chip, 2014, 14, 3993-3999.
Single layer linear array of microbeads for multiplexed analysis of DNA and proteins, Biosensors and Bioelectronics, 2014, 54, 297-305.
Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells, Lab on a Chip, 2013, 13, 1060-1069.
Integrated sieving microstructures on microchannels for biological cell trapping and droplet formation, Lab on a Chip, 2011, 11, 3352-3355.
Real-time monitoring of cell-cell communications evoked by mechanical stimulation of suspension cells using an integrated microfluidics chip, Lab on a Chip, 2010, 10, 2271-2278.
Microfluidic formation of single cell array for parallel analysis of CRAC channel activation and inhibition, Analytical Biochemistry, 2010, 396, 173-179.
A microfluidic device with microbead array for sensitive virus DNA detection and genotyping using quantum dots as fluorescence labels, Biosensors & Bioelectronics, 2010, 25, 2402-2407.
3-D streamline steering by nodes arrayed in an entangled microfluidic network, Lab on a Chip, 2007, 7, 1712-1716.
Generation of linear and non-linear concentration gradients along microfluidic channel by microtunnel controlled stepwise addition of sample solution, Lab on a Chip, 2007, 7, 1371-1373.
Dose-dependent cell-based assays in V-shaped microfluidic channels, Lab on a Chip, 2006, 6, 921-929.
Microfluidics technology for manipulation and analysis of biological cells, Analytica Chimica Acta, 2006, 560, 1-23.
Hydrodynamic simulation of cell docking in microfluidic channels with different dam structures, Lab on a Chip, 2004, 4, 53–59.
Cell docking and on-chip monitoring of cellular reactions under controlled concentration gradient on a microfluidic device, Analytical Chemistry, 2002, 74, 3991-4001.
Generation of concentration gradient by diffusive mixing and consecutive dilution in a microfluidic chip, Lab on a Chip, 2002, 2, 158-163.
Cancer Biology & NanomedicineGlutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance, Nanomedicine. 2021, 16, 1411–1427.
Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ, Oncogene, 2021, 40, 1775–1791.
Magnetothermal miniature reactors based on iron oxide nanocubes-coated liquid marbles, Advanced Healthcare Materials, 2021, 2001658 (8 pages).
Single-cell EMT-related transcriptional analysis uncovers the intra-cluster heterogeneity of tumor cell clusters in epithelial ovarian cancer ascites, Oncogene, 2020, 39(21), 4227–4240.
Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy, Theranostics, 2020, 10(3), 1181-1196.
Recent Progress of Ferroptosis Inducers for Cancer Therapy, Advanced Materials, 2019, 1904197, pp25.
Efficient RNA drug delivery using red blood cell extracellular vesicles, Nature Communications, 2018, 9(1), 2359 (15 pages).
Transparent and gas-permeable liquid marbles for culturing and drug sensitivity test of tumor spheroids, Advanced Healthcare Materials, 2017, 1700185.
Chemoresistant lung cancer stem cells display high DNA repair capability to remove cisplatin-DNA damage, British Journal of Pharmacology, 2017, 174(4), 302-313.
Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in silicon nanowire microenvironment, Nanomedicine: Nanotechnology, Biology, and Medicine, 2014, 10(6), 1153-63.
Reorganization of cytoskeleton and transient activation of Ca2+ channels in mesenchymal stem cells cultured on silicon nanowire arrays, ACS Applied Materials & Interfaces, 2013, 5, 13295?13304.
Multienzyme-nanoparticles amplification for sensitive virus genotyping in microfluidic microbeads array using Au nanoparticle probes and quantum dots as labels, Biosensors and Bioelectronics, 2011, 29, 89-96.
Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells, ACS Nano, 2010, 4, 6439-6448.
Inhibition of proliferation and differentiation of mesenchymal stem cells by carboxylated carbon nanotubes, ACS Nano, 2010, 4(4), pp 2185–2195.
COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis, Clinical Cancer Research, 2008, 14 (16), 5061-5068.
DNA-directed self-assembly of gold nanoparticles into binary and ternary nanostructures, Nanotechnology, 2007, 18, 015102 (7 pages).
Hypoxia induces the activation of human hepatic stellate cells LX-2 activation through TGF-b signaling pathway, FEBS Letters, 2007, 581, 203-210.
Clustin plays an important role in hepatocellular carcinoma metastasis, Oncogene, 2006, 25, 1242-1250.
Molecular mechanisms of survival and apoptosis in RAW 264.7 macrophages under oxidative stress, Apoptosis, 2005, 10, 545-556.
Association of overexpression of vimentin and hepatocellular carcinoma metastasis. Oncogene, 2004, 23, 298-302.
20 December 2021


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