Prof. Kenneth K. W. LO

罗锦荣教授


PhD (HK)


Professor of Department of Chemistry
Associate Director of Talent and Education Development Office

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Contact Information
Office:YEUNG-G6625
Phone:+852 3442-7231
Fax:+852 3442-0522
Email:bhkenlo@cityu.edu.hk
Web:Personal Homepage
ORCID ID:0000-0002-2470-5916
Scopus Author ID:26032181200



Research Interests
Analytical, Inorganic and Organometallic Chemistry
Photophysics and Photochemistry
Bioconjugation
Biomolecular and Cellular Probes
Photocytotoxic Reagents




Prof Kenneth Lo obtained his BSc (1993) and PhD (1997) degrees atThe University of Hong Kong. His PhD work centred on the design of luminescent transition metal complexes as DNA and metal-ion probes; and the photophysical and photochemical studies of luminescent polynuclear coinage metal chalcogenide complexes. From 1997 to 1999, he worked as aCroucher FoundationPostdoctoral Research Fellowin the research groups ofProf H. Allen O. Hill, FRSandDr Luet-Lok Wongof theInorganic Chemistry Laboratory,University of Oxford. He carried out research work on genetic engineering and electrochemistry of cytochrome P450cam and putidaredoxin. Prof Lo joined theDepartment of Biology and ChemistryofCity University of Hong Kongas Assistant Professor in 1999 and became Associate Professor (Scale B) in 2003, Associate Professor (Scale A) in 2007, and Professor in 2011. He is currently the Programme Leader ofBSc (Hons) Applied Chemistry/ Chemistryof the Department. He was the Associate Head of the Department from 2010 to 2011. At the College level, he is a member of the College Validation and Monitoring Committee (CVMC) and the College Graduate Studies Committee (CGSC). At the University level, he is currently on the Academic Conduct Committee (ACC) under theChow Yei Ching School of Graduate Studies.
Prof Lo's research interest is the utilization of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes, with a focus on the development of intracellular sensors, photoactive labels, and bioimaging reagents. He received TheAPA Prize for Young ScientistfromThe Asian and Oceanian Photochemistry Associationin 2005 and The Distinguished Lectureship Award fromThe Chemical Society of Japanin 2011. He is currently on the Editorial Advisory Board ofInorganic Chemistryand is an Associate Editor ofRSC Advances. He will be one of the Chairs of theGordon Research ConferenceMetals in Medicine 2018. He was awarded a Croucher Senior Research Fellowship from theCroucher Foundationin 2015.


Publications
Google Scholar Citations
L. C.-C. Lee, H. M.-H. Cheung, H.-W. Liu and K. K.-W. Lo, "Exploitation of Environment-sensitive Luminophores in the Design of Novel Sydnone‐based Bioorthogonal Imaging Reagents
https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201803452"> Link ).
K. Y. Zhang, P. Gao, G. Sun, T. Zhang, X. Li, S. Liu, Q. Zhao, K. K.-W. Lo, and W. Huang, "Dual-phosphorescent Iridium(III) Complexes Extending Oxygen Sensing from Hypoxia to Hyperoxia
https://pubs.acs.org/doi/abs/10.1021/jacs.8b02492"> Link ).
A. M.-H. Yip and K. K.-W. Lo "Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Polypyridine Complexes Containing a Poly(ethylene glycol) Pendant or Bioorthogonal Reaction Group as Biological Probes and Photocytotoxic Agents
https://www.sciencedirect.com/science/article/pii/S7051"> Link ).
L. C.-C. Lee, K.-K. Leung and K. K.-W. Lo, "Recent Development of Luminescent Rhenium(I) Tricarbonyl Polypyridine Complexes as Cellular Imaging Reagents, Anticancer Drugs, and Antibacterial Agents
https://pubs.rsc.org/en/Content/ArticleLanding/2017/DT/C7DT03465B#!divAbstract"> Link ).
C. T.-S. Lau, C. Chan, K. Y. Zhang, V. A. L. Roy and K. K.-W. Lo, "Photophysical, Cellular Uptake, and Bioimaging Studies of Luminescent Ruthenium(II) Polypyridine Complexes Containing a D-Fructose Pendant
https://onlinelibrary.wiley.com/doi/abs/10.1002/ejic.201701038"> Link ). Included in the Cluster Issue entitled "Luminescent Materials: Metal Complexes, Clusters, and Nanomaterials" ( Link ). Guest Editorial ( Link ).
K. K.-S. Tso, H.-W. Liu and K. K.-W. Lo, "Phosphorogenic Sensors for Biothiols Derived from Cyclometalated Iridium(III) Polypyridine Complexes Containing a Dinitrophenyl Ether Moiety
https://www.sciencedirect.com/science/article/pii/S2751?via%3Dihub"> Link ).
Y. Li, S. Yin, Y. Lu, H. Zhou, H. Jiang, N. Niu, H. Huang, L. Zhang, K. K.-W. Lo and C. Yu, "Choline Sensing Based on In Situ Polymerization of Aniline on the Surface of Upconverting Nanoparticles
https://pubs.rsc.org/en/Content/ArticleLanding/2017/TB/C7TB01589E#!divAbstract"> Link ).
X. Huang, S. A. Shahzad, Y. Li, Y. Zhang, H. Zhou, H. Jiang, K. K.-W. Lo and C. Yu. "Silver Nanoclusters Capped Silica Nanoparticles as a Ratiometric Photoluminescence Nanosensor for the Selective Detection of I^? and S^2?
https://www.sciencedirect.com/science/article/pii/S8607?via%3Dihub"> Link ).
Y. Zhang, Y. Li, C. Zhang, Q. Zhang, X. Huang, M. Yang, S. A. Shahzad, K. K.-W. Lo and C. Yu and S. Jiang, "Fluorescence Turn-on Detection of Alkaline Phosphatase Activity Based on Controlled Release of PEI-capped Cu Nanoclusters from MnO₂ Nanosheets
https://link.springer.com/article/10.1007/s00216-017-0420-9"> Link ).
H.-W. Liu, W. H.-T. Law, L. C.-C. Lee, J. C.-W. Lau and K. K.-W. Lo, “Cyclometalated Iridium(III) Bipyridine–Phenylboronic Acid Complexes as Bioimaging Reagents and Luminescent Probes for Sialic Acids”, Chemistry – An Asian Journal, 2017, 12, 1545 – 1556 ( Link ).
T. S.-M. Tang, H.-W. Liu and K. K.-W. Lo, “Monochromophoric Iridium(III) Pyridyl-tetrazine Complexes as a Unique Design Strategy for Bioorthogonal Probes with Luminogenic Behavior”, Chemical Communications, 2017, 53, 3299 – 3302 ( Link ). Cover Picture for Issue 23 ( Link ).
S. P.-Y. Li, A. M.-H. Yip, H.-W. Liu and K. K.-W. Lo, “Installing an Additional Emission Quenching Pathway in the Design of Iridium(III)-based Phosphorogenic Biomaterials for Bioorthogonal Labeling and Imaging
http://www.sciencedirect.com/science/article/pii/S3313" target="_blank">Link ).
T. S.-M. Tang, H.-W. Liu and K. K.-W. Lo, “Structural Manipulation of Ruthenium(II) Polypyridine Nitrone Complexes to Generate Phosphorogenic Bioorthogonal Reagents for Selective Cellular Labelling”,Chemistry – A European Journal,2016,22, 9649 – 9659 (Link ).
K. K.-S. Tso, K.-K. Leung, H.-W. Liu and K. K.-W. Lo, “Photoactivatable Cytotoxic Agents Derived from Mitochondria-targeting Luminescent Iridium(III) Poly(ethylene glycol) Complexes Modified with a Nitrobenzyl Linkage”,Chemical Communications,2016,52, 4557 – 4560 (Link ).
L. C.-C. Lee, J. C.-W. Lau, H.-W. Liu and K. K.-W. Lo, “Conferring Phosphorogenic Properties on Iridium(III)-based Bioorthogonal Probes through the Modification with a Nitrone Unit”,Angewandte Chemie International Edition,2016,55, 1046 – 1049 (Link ).
K. K.-W. Lo, “Luminescent Iridium(III) and Rhenium(I) Complexes as Biomolecular Probes and Imaging Reagents”.Advances in Inorganic Chemistry,2016,68, 97 – 140 (Link).
K. K.-W. Lo, “Luminescent Rhenium(I) and Iridium(III) Polypyridine Complexes as Biological Probes, Imaging Reagents, and Photocytotoxic Agents”,Accounts of Chemical Research,2015,48, 2985 – 2995 (Link).Cover Picture for Issue 12 (Link ).
T. S.-M. Tang, A. M.-H. Yip, K. Y. Zhang, H.-W. Liu, P. L. Wu, K. F. Liu, K. W. Cheah and K. K.-W. Lo, “Bioorthogonal Labeling, Bioimaging, and Photocytotoxicity Studies of Phosphorescent Ruthenium(II) Polypyridine Dibenzocyclooctyne Complexes”,Chemistry – A European Journal,2015,21, 10729 – 10740 (Link ;).
K. Y. Zhang, H.-W. Liu, M.-C. Tang, A. W.-T. Choi, N. Zhu, X.-G. Wei, K.-C. Lau and K. K.-W. Lo, “Dual-Emissive Cyclometalated Iridium(III) Polypyridine Complexes as Ratiometric Biological Probes and Organelle-Selective Bioimaging Reagents”,Inorganic Chemistry,2015,54, 6582 – 6593 (Link ).
K. K.-W. Lo and K. K.-S. Tso, “Functionalization of Cyclometalated Iridium(III) Polypyridine Complexes for the Design of Intracellular Sensors, Organelle-targeting Imaging Reagents, and Metallodrugs”,Inorganic Chemistry Frontiers,2015,2, 510 – 524 (Link ).
A. W.-T. Choi, H.-W. Liu and K. K.-W. Lo, “Rhenium(I) Polypyridine Dibenzocyclooctyne Complexes as Phosphorescent Bioorthogonal Probes: Synthesis, Characterization, Emissive Behavior, and Biolabeling Properties”,Journal of Inorganic Biochemistry,2015, 148, 2 – 10 (Link ). The 12^thEuropean Biological Inorganic Chemistry Conference (EuroBIC 12) (Link ).
A. W.-T. Choi, K. K.-S. Tso, V. M.-W. Yim, H.-W. Liu and K. K.-W. Lo, “Modification of 1,2,4,5-Tetrazine with Cationic Rhenium(I) Polypyridine Units to Afford Phosphorogenic Bioorthogonal Probes with Enhanced Reaction Kinetics”,Chemical Communications,2015,51, 3442 – 3445 (Link ).
K. K.-W. Lo, T. S.-M. Tang, K.-K. Leung, M.-W. Louie, H.-W. Liu and S. H. Cheng, “Phosphorescent Biscyclometalated Iridium(III) Ethylenediamine Complexes Functionalized with Polar Ester or Carboxylate Groups as Bioimaging and Visualization Reagents”,Dalton Transactions,2015,44, 4945 – 4956 (Link). Dalton Discussion 15: Metal Ions in Medical Imaging: Optical, Radiopharmaceutical and MRT Contrast (Link ).
A. W.-T. Choi, V. M.-W. Yim, H.-W. Liu and K. K.-W. Lo, “Rhenium(I) Polypyridine Diamine Complexes as Intracellular Phosphorogenic Sensors: Synthesis, Characterization, Emissive Behavior, Biological Properties, and Nitric Oxide Sensing”,Chemistry–A European Journal,2014,20, 9633 – 9642 (Link ).
W. H.-T. Law, K.-K. Leung, L. C.-C. Lee, C.-S. Poon, H.-W. Liu and K. K.-W. Lo, “Cyclometalated Iridium(III) Bipyridyl–Phenylenediamine Complexes with Multicolor Phosphorescence: Synthesis, Electrochemistry, Photophysics, and Intracellular Nitric Oxide Sensing”,ChemMedChem,2014,9, 1316 – 1329 (Link).
K. Y. Zhang and K. K.-W. Lo, Metal Complexes for Cell and Organism Imaging. In Inorganic Chemical Biology: Principles, Techniques and Applications; G. Gasser Ed.; John Wiley & Sons: UK, 2014, pp 99 – 148 (Link).
J. Liu, K.-K. Yee, K. K.-W. Lo, K. Y. Zhang, W.-P. To, C.-M. Che and Z. Xu, “Selective Ag(I) Binding, H2S Sensing, and White-Light Emission from an Easy-to-Make Porous Conjugated Polymer”,Journal of the American Chemical Society,2014,136, 2818 – 2824 (Link).
S. P.-Y. Li and K. K.-W. Lo, “Utilization of the Photophysical and Photochemical Properties of Phosphorescent Transition Metal Complexes in the Development of Photofunctional Cellular Sensors, Imaging Reagents, and Cytotoxic Agents”,RSC Advances,2014,4, 10560 – 10585 (Link).
W. H.-T. Law, L. C.-C. Lee, M.-W. Louie, H.-W. Liu, T. W.-H. Ang and K. K.-W. Lo, "Phosphorescent Cellular Probes and Uptake Indicators Derived from Cyclometalated Iridium(III) Bipyridine Complexes Appended with a Glucose or Galactose Entity
http://pubs.acs.org/doi/abs/10.1021/ic401714p" target="_blank">Link).
K. Y. Zhang, K. K.-S. Tso, M.-W. Louie, H.-W. Liu and K. K.-W. Lo, "A Phosphorescent Rhenium(I) Tricarbonyl Polypyridine Complex Appended with a Fructose Pendant That Exhibits Photocytotoxicity and Enhanced Uptake by Breast Cancer Cells
http://pubs.acs.org/doi/abs/10.1021/om400612f" target="_blank">Link).
K. Y. Zhang and K. K.-W. Lo, Chemosensing and Diagnostics. In Coordination and Organometallic Chemistry (Volume 8) of Comprehensive Inorganic Chemistry II; V. W.-W. Yam Ed.; Elsevier: Amsterdam, 2013, pp 657 – 732 (Link).
S. P.-Y. Li, C. T.-S. Lau, M.-W. Louie, Y.-W. Lam, S.-H. Cheng and K. K.-W. Lo, "Mitochondria-targeting Cyclometalated Iridium(III)–PEG Complexes with Tunable Photodynamic Activity
http://dx.doi.org/10.1016/j.biomaterials.2013.06.028" target="_blank">Link).
K. K. W. Lo, W. H. T. Law, J. C. Y. Chan, H. W. Liu and K. Y. Zhang, "Photophysical and Cellular Uptake Properties of Novel Phosphorescent Cyclometallated Iridium(III) Bipyridine D-Fructose Complexes
http://pubs.rsc.org/en/content/articlelanding/2013/mt/c3mt20276c#!divAbstract">Link). An invited paper included in the Themed IssueMetallomics in China.
C. Y. S. Chung, S. P. Y. Li, M. W. Louie, K. K. W. Lo and V. W. W. Yam, "Induced Self-assembly and Disassembly of Water-soluble Alkynylplatinum(II) Terpyridyl Complexes with “Switchable” Near-infrared (NIR) Emission Modulated by Metal–Metal Interactions over Physiological pH: Demonstration of pH-responsive NIR Luminescent Probes in Cell-imaging Studies
http://pubs.rsc.org/en/content/articlelanding/2013/sc/c3sc50196e" target="_blank">Link).
X. Chen, G. Zhu, Y. Yang, B. Wang, L. Yan, K. Y. Zhang, K. K.-W. Lo and W. Zhang, “A Diamond Nanoneedle Array for Potential High-Throughput Intracellular Delivery
http://onlinelibrary.wiley.com/doi/10.1002/adhm.201200362/abstract" target="_blank">Link). Cover Picture for Issue 8 (Link).
A. W.-T. Choi, C.-S. Poon, H.-W. Liu, H.-K. Cheng and K. K.-W. Lo, “Rhenium(I) Polypyridine Complexes Functionalized with a Diaminoaromatic Moiety as Phosphorescent Sensors for Nitric Oxide,New Journal of Chemistry,2013,37, 1711 – 1719 (Link). An invited paper included in the China Souvenir Special Issue. Cover Picture for Issue 6 (Link).
K. K. W. Lo, B. T. N. Chan, H. W. Liu, K. Y. Zhang, S. P. Y. Li and T. S. M. Tang, “Cyclometalated Iridium(III) Polypyridine Dibenzocyclooctyne Complexes as the First Phosphorescent Bioorthogonal Probes”,Chemical Communications,2013,49, 4271 – 4273 (Link).