基本信息

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李银辉
职称：副教授 性别：男
职务： 办公电话：
移动电话： 家庭电话：
家庭住址： 电子邮箱：yinhuili16@163.com

工作学习经历

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2016.12---至今 湘潭大学化学学院，副教授，博士生导师
2015.1---2017.1 香港浸会大学 香江****
2012.12---2016.10 湖南大学化学化工学院，讲师，硕士生导师
2009.9---2012.12 湖南大学化学化工学院，博士



主讲课程

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仪器分析，仪器分析实验
研究方向

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分子识别与化学生物传感
主要学术成果

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学术论文：
1. Yinhui Li, Di Xu, Hei-Nga Chan, Chung-Yan Poon, See-Lok Ho, Hung-Wing Li,* and Man Shing Wong*.Dual-Modal NIR-Fluorophore Conjugated MagneticNanoparticle for Imaging Amyloid β Species In Vivo. Small, 2018, Doi.org/10.1002/smll..
2. Yinhui Li, Di Xu, Anyang Sun,* See-Lok Ho, Chung-Yan Poon, Hei-Nga Chan, Olivia T. W. Ng, Ken K. L. Yung, Hui Yan, Hung-Wing Li,* and Man Shing Wong*. Fluoro-Substituted Cyanine for Reliable in vivo Labelling of Amyloid-β Oligomers and Neuroprotection against Amyloid-β Induced Toxicity. Chemical Science, 2017, 8, 8279-8284.
3. Yinhui Li,* Wei Wu, Jinfeng Yang, Lin Yuan, Changhui Liu, Jing Zheng, and Ronghua Yang*. Engineering a Nanolab for the Determination of Lysosomal Nitric Oxide by Rational Design of a pH-activatable Fluorescent Probe. Chemical Science, 2016, 7, 1920-1925.
4. Di Xu, Yinhui Li,* Chung-Yan Poon, Hei-Nga Chan, Hung-Wing Li, and Man Shing Wong*. A Zero Cross-Talk Ratiometric Two-Photon Probe for Imaging of Acid pH in Living Cells and Tissues and Early Detection of Tumor in Mouse Model.Analytical Chemistry, 2018, 90, 8800-8806.
5. Weifen Niu, Lei Guo, Yinhui Li,* Shaomin Shuang, Chuan Dong* and Man Shing Wong*, Highly Selective Two-Photon Fluorescent Probe for Ratiometric Sensing and Imaging Cysteine in Mitochondria. Analytical Chemistry, 2016, 88, 1908-1914.
6. Yinhui Li, Di Xu, See-Lok Ho, Hung-Wing Li,* Ronghua Yang,* Man Shing Wong *, A Theranostic Agent for in Vivo Near-Infrared Imaging of β-Amyloid Species and Inhibition of β-Amyloid Aggregation. Biomaterials, 2016, 94, 84-92.
7. Wenjie Zhao,^? Yinhui Li,^?(共同一作) Sheng Yang, Yun Chen, Jing Zheng, Changhui Liu, Zhihe Qing, Jishan Li, and Ronghua Yang*, Target-Activated Modulation of Dual-Color and Two-Photon Fluorescence of Graphene Quantum Dots for in Vivo Imaging of Hydrogen Peroxide. Analytical Chemistry, 2016, 88, 4833-4840.
8. Yinhui Li, Yirong Zhao, Winghong Chan, Yijun Wang, Qihua You, Jing Zheng, Changhui Liu, Jishan Li, Sheng Yang, Ronghua Yang*. Selective Tracking of Lysosomal Cu²⁺ Ions Using Simultaneous Target- and Location Activated Fluorescent Nanoprobe. Analytical Chemistry, 2015, 87, 584-591.
9. Yinhui Li, Yijun Wang, Sheng Yang, Yirong Zhao, Lin Yuan, Jing Zheng, and Ronghua Yang*. Hemicyanine-based High Resolution Ratiometric near-Infrared Fluorescent Probe for Monitoring pH Changes in Vivo. Analytical Chemistry, 2015, 87, 2495-2503.
10. Yinhui Li, Yu Duan, Jing Zheng, Jishan Li, Wenjie Zhao, Sheng Yang and Ronghua Yang*. Self-assembly of Graphene Oxide with Silylated Dye for Rapid and Sensitive Colorimetric Detection of Fluoride Ions in Aqueous Solution. Analytical Chemistry, 2013. 85, 11456-11463.
11. Yinhui Li, Yu Duan, Jishan Li, Jing Zheng, Huan Yu, and Ronghua Yang*. Simultaneous Nucleophilic-Substituted and Electrostatic Interactions for Thermal Switching of Spiropyran: A New Approach for Rapid and Selective Colorimetric Detection of Thiol-Containing Amino Acids. Analytical Chemistry, 2012, 84, 4732-4738.
12. Yinhui Li, Hao Wang, Jishan Li, Jing Zheng, Xinhua Xu and Ronghua Yang*. Simultaneous Intracellular β-D-Glucosidase and Phosphodiesterase I Activities Measurement Based on A Triple-Signaling Fluorescent Probe. Analytical Chemistry, 2011, 83, 1268-1274.
13. Jia Tao,^? Yinhui Li,^?(共同一作) Peng Zhao, Jishan Li, Yu Duan, Wenjie Zhao, Ronghua Yang*. Development of Spiropyran-based Electrochemical Sensor via Simultaneous Photochemical and Target-Activatable Electron Transfer. Biosensors and Bioelectronics, 2014, 62, 151-157.
14.Jinyin Ge, Li Fan, Kai Zhang, Ting Ou, Yinhui Li,* Caihong Zhang, Chuan Dong,Shaomin Shuang*, Man Shing Wong*.A two-photon ratiometric fluorescent probe for effective monitoring oflysosomal pH in live cells and cancer tissues.Sensors and Actuators B: Chemical, 2018, 262, 913-921.
15.Yinhui Li, Chen Chen, Di Xu, Chung-Yan Poon, See-Lok Ho, Rui Zheng, Qiong Liu, Guoli Song, Hung-Wing Li*, and Man Shing Wong*. Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model. ACS Omega, 2018, 3, 6812-6819.
16. Jia Tao, Peng Zhao, Yinhui Li*, Wenjie Zhao, Yue Xiao, Ronghua Yang*, Fabrication of an Electrochemical Sensor Based on Spiropyran for Sensitive and Selective Detection of Fluoride Ion. Analytica Chimica Acta, 2016, 918, 97-102.
17. Qian Chen, Jinfeng Yang, Yinhui Li,* Jing Zheng, and Ronghua Yang. Sensitive and Rapid Detection of Endogenous Hydrogen Sulfide Distributing in Different Mouse Viscera via a Two-photon Fluorescent Probe. Analytica Chimica Acta, 2015, 896, 128-136.
18. Rongxing Luo,^? Yinhui Li,^?(共同一作) Qifeng Zhou, Jing Zheng,* Dandan Ma, Pinting Tang, Sheng Yang, Zhihe Qing, Ronghua Yang*, SERS monitoring the dynamics of local pH in lysosome of living cells during photothermal therapy. Analyst, 2016, 141, 3224-3227.
19. Kai Zhang, Wei Wu, Yinhui Li,* Mingtai Sun, Huan Yu,* Man Shing Wong*, Carbazole-based two-photon fluorescent probe for selective imaging of mitochondrial hydrogen peroxide in living cells and tissues. RSC Advances, 2016, 6, 115298-115302.
20. Yirong Zhao, Yinhui Li,* Yijun Wang, Jing Zheng, Ronghua Yang. A New Strategy for Fluorometric Detection of Ascorbic Acid Based on Hydrolysis and Redox Reaction. RSC Advances, 2014, 4, 35112-35115.
21. Yinhui Li, Jinfeng Yang, Changhui Liu, Jishan Li, Ronghua Yang*, Colorimetric and Fluorescent Sensing for Biological Thiols in Aqueous Solution. Chinese Chemical Letters, 2013, 24, 96-98.
22. Yinhui Li, Jianping Li, Xiang Xia, Kangbing Zou, Ruoxin Li, Xinhua Xu*. A new synthesis of alkynyl tellurides promoted by CsOH and 4 ? MS. Chinese Chemical Letters, 2008, 19, 1401-1402.
23. Jing Zheng, Guizhi Zhu, Yinhui Li, Chunmei Li, Mingxu You, Tao Chen, Erqun Song, Ronghua Yang*, Weihong Tan*. A Multifunctional Spherical Nucleic Acid-Conjugate Platform Based on Self-Assembled DNA Biopolymer for High Perform Cancer Therapy. ACS Nano, 2013, 7, 6545-6554.
24. Lili Wang, Jing Zheng, Yinhui Li, Sheng Yang, Changhui Liu, Yue Xiao，Jishan Li, Zhong Cao, and Ronghua Yang. AgNP-DNA@GQDs Hybrid: A New Approach for Sensitive Detection of H₂O₂ and Glucose via Simultaneous AgNP Etching and DNA Cleavage. Analytical Chemistry, 2014, 86, 12348-12354.
25. Renhua Qiu, Xinhua Xu*, Yinhui Li, Guoping Zhang, Lingling Shao, Delie An and Shuangfeng Yin. Synthesis and Structure of Air-Stable Lewis Acidic Binuclear Complex of Zirconocene Pentafluorophenylsulfonate and its Catalytic Application in the Allylation of Carbonyl Compounds with Tetraallyltin. Chemical Communications, 2009,1679-1681.
申请专利：
1. Yinhui Li，Di Xu，See-Lok Ho，Chung-Yan Poon，Hei-Nga Chan，Hung Wing Li，Ricky M S Wong，Imaging Beta-Amyloid Peptides Aggregation，2016.8.25，美国，USA1。
主持科研项目：
1.国家自然科学基金面上项目，**，“基于AD早期诊断的Aβ寡聚体探针设计及NIRF-MRI双模态成像研究”，2020.1-2023.12。
2. 国家自然科学基金青年基金，**，“基于螺吡喃结构互变的比率型双光子探针设计及肝脏中碱性磷酸酶表达水平分析”，2014.1-2016.12。
3. 湖湘青年英才项目，2020RC3046，2021.1-2023.12。
4. 湖南省科技创新计划项目，2017XK2048，“长株潭高层次人才聚集工程”，2017.1-2019.12。
5. 湖南省自然科学基金“优秀青年基金”，“功能分子探针的设计与成像研究”，2019.1-2021.12。
6. 湖南省自然科学基金青年基金，2015JJ3035，“比率型双光子传感平台的构建及其在生物成像中的应用研究”，2015.1-2017.12。
7. 香江****计划科研业务费，2015.1-2017.1。
8. 中国博士后科学基金第58批面上项目一等资助，2015M580685，2015.10-2017.1。
9. 湖南大学化学生物传感与计量学国家重点实验室开放课题，**，2018.4-2020.3。
10. 湘潭大学学术带头人科研启动项目。

个人简介

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李银辉，男，1984年出生于湖南平江，2012年10月博士毕业于湖南大学分析化学专业（师从国家****、****杨荣华教授），同年留校工作，任化学化工学院讲师，化学生物传感与计量学国家重点实验室成员。主要从事分子探针的开发与生物传感应用研究。2014年，入选“香江****计划”，在香港浸会大学化学系开展为期两年的研究工作，主要开发可用于阿尔茨海默病早期诊疗的Aβ成像试剂和抑制剂。2016年12月，任湘潭大学化学学院副教授，分析化学学术带头人，2017年入选“长株潭高层次人才聚集工程”，2020年入选“湖湘青年英才”。主持国家自然科学基金、湖南省自然科学基金“优秀青年基金”、中国博士后科学基金面上项目一等资助等多项科研项目，以第一作者或通讯作者在ChemicalScience、AnalyticalChemistry、Small、Biomaterials等国际高水平期刊上发表SCI论文二十余篇。