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研究员
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博士
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wuxin@isa.ac.cn
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研究员
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科研人员
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湖南省长沙市芙蓉区马坡岭远大二路644号
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博士，研究员，中国科学院大学博士生导师、兼南昌大学和湖南农业大学硕士生和博士生导师。2005年7月毕业于华中农业大学；2010年在中国科学院大学获得理学博士学位，导师印遇龙研究员。毕业后在中国科学院亚热带农业生态所先后任创新助理研究员、副研究员和研究员；期间在南昌大学生命科学与食品工程学院从事博士后研究，2013-2014年在法国国家农业科学研究院（INRA）访问****、2020年1-4月在荷兰伊拉斯姆大学医学院访问****。
主要研究母体与子代氨基酸、核苷酸、微量元素的营养代谢与生理功能的联系，先后主持十三五国家重点研发计划课题、十二五国家科技支撑计划子课题、国家自然科学基金青年基金等多项。在国内外公开发表学术论文160多篇，其中以第一作者或通讯作者发表论文SCI收录70多篇，参编专著6部，授权国家发明专利16项。以前三完成人获国家自然科学奖二等奖、中国科学院科技促进发展奖、中华农业科技奖一等奖和湖南省发明奖一等奖等省部级奖8项。
入选国家“****”科技创新领军人才、国家创新人才推进计划中青年科技创新领军人才、湖南省121创新人才工程第三层次人选、长沙市优秀青年科技人才等。
主要社会兼职：中国农学会理事、微量元素与食物链分会秘书长、世界中联中医与农业分会专家委员会副主任、世界中医药学会联合会中医与农业分会副理事长、中国畜牧兽医学会家畜生态学分会理事、中国生物物理学会生物微量元素分会理事等。
研究方向：母体与子代氨基酸、核苷酸、微量元素和饲用植物及其提取物的营养代谢，营养与生物钟，畜禽健康和环境因子互作等。

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代表论著（*为通讯作者）：
1.Y. Liu, S. Guo, C. Xie, K. Niu, H. De Jonge, X. Wu*. Uridine inhibits stemness of intestinal stem cells via mTOR in 3D intestinal organoids and mice. RSC Advances, 2020, 10(11): 6377-6387
2.C. Xie, Q. Wang, G. Li, Z. Fan, H. Wang, X. Wu *. Dietary supplement with nucleotides in the form of uridine monophosphate or uridine stimulate the intestinal development and promote nucleotide transport in weaned piglets. J Sci Food Agri, 2019, 99: 6108–6113
3.Y. Liu, Y. Zhang, J. Yin, X. Zhou, X. Wu*, Y. Yin, Z. Ruan*. Uridine dynamic administration affects circadian variations in lipid metabolisms in the liver of high-fat diet-fed mice. Chron Inter, 2019, 36:9, 1258-1267
4.G. Li, C. Xie, Q. Wang, D. Wan*, X. Wu*, Y. Yin. Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets. Food & Function, 2019, 10, 4081-4089
5.Y. Yin, H. R. de Jonge, X. Wu*, Y. Yin. Mini-gut: a promising model for drug development. Drug Discovery Today, 2019, 24(9):1784-1794
6.L. Qin, W. Ji, J. Wang, B. Li, J. Hu*, X. Wu*. Dietary supplementation with yeast glycoprotein or antibiotics have different effects on growth performance, intestinal mucosal morphology, immune response and colonic microbiome in weaned piglets. Food & Function, 2019, 10: 2359-2371
7.Liu Y., Wan D., X. Zhou, R. Zheng, X. Wu*, Yulong Yin. Dynamic feeding of methionine rhythmically influences glucose and lipid metabolism in the liver of laying hens. Poultry Science, 2019, 98:2231–2240
8.Y. Yin, De Jonge HR, Xin Wu*, and Yulong Yin. Enteroids for nutritional studies. Molecular Nutrition & Food Research. 2019, 18: e**
9.张娟，邓泽元，吴信*. 胆汁酸对代谢性疾病的调控. 中国生物化学与分子生物学报，2019，35（4）：1007-7626
10.周凯，刘春龙，吴信*. 集约化饲养条件下饲养密度对猪生长性能和健康影响的研究进展，动物营养学报，2019，31(1): 57-62
11.吴信，万丹，印遇龙*. 畜禽养殖废弃物资源化利用与现代生态养殖模式. 农学学报, 2018 (1) :163-166
12.X. Wu*, C. Xie, C. Long, J. Li, X. Zhou, Z. Fan, F. Blachier, Y. Yin*. Effects of a daily 3-meal pattern with different dietary protein contents on pig growth performance, carcass and muscle quality traits. J Sci Food Agri, 2018, 98(1): 415-421
13.Yin J., Y. Li, H. Han, S. Chen, J. Gao, G. Liu, X. Wu*, J. Deng, X. Huang, R. Fang, T. Li*, R. J. Reiter, G. Zhu, W. Ren*, Y. Yin. Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high fat diet-fed mice. Journal of Pineal Research, 2018:e12524
14.X. Wu, L. Gao, K. Zhou, X. Li, X. Lin, D. Wan, X. Xiong, G. Liu, Y. Yin*. Deposition and transport of trace mineral elements were affected by stocking density in fattening pigs. J Trace Elem Med Biol, 2018, 50：566-571
15.X. Lin, Y. Liu, T. Meng, C. Xie, X. Wu*, Y. Yin. Circadian calcium feeding regime in laying hens related to zinc concentration, gene expression of circadian clock, calcium transporters and oxidative status. J Trace Elem Med Biol, 2018, 50：518-526
16.X. Zhou, H. Zhang, L. He, X. Wu*, Y. Yin. Long-term L-serine administration reduces food intake and improves oxidative stress and Sirt1/NFκB pathway in the hypothalamus in aging mice. Frontiers in Endocrinology, 2018,9:476
17.D. Wan, Y. M. Zhang, X. Wu*, X. Lin, X. G. Shu, X. H. Zhou, W.G. Xing, H. N. Liu, L. Li, Y. Li, H. T. Du, Yulong Yin*. Maternal dietary supplementation with ferrous N-carbamylglycinate chelate affects sow reproductive performance and iron status of neonatal piglets. Animal, 2018, 12(7):1372-1379
18.X. Zhou, L. He, S. Zuo, Y. Zhang, C. Long, P. Huang, C. Wu, G. Liu, X. Wu *, Y. Yin*. Serine attenuates high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes. BBA-Molecular Basis of Disease, 2018, 1864：488–498
19.Wu X., C. Xie, X. Guo, C. Long, T. Zhang, T. Gao, Y. Yin*. A Maternal meal Feeding Pattern with Varying Crude Protein Affacted Milk Lipid Profile in A Sow-Piglet Model. Scientific Reports, 2017, 7: 13742
20.X. Zhou, L. He, C. Wu, Y. Zhang, X. Wu*, Y. Yin. Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice. Molecular Nutrition & Food Research, 2017, 61(11)：**
21.Liu Y., Lin X., Zhou X., Wan D., Wu X.*, Yin Y. Effects of dynamic feeding low and high methionine diets on egg quality traits in laying hens. Poultry Science, 2017, 96(5): 1459-1465
22.C. Xie, X. Wu*, C. Long, Q. Wang, Z. Fan, S. Li, Y. Yin*. Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows. BMC Veterinary Research, 2016 12:243
23.B. Li, H. Zhou, X. Wu*, Z. Chen, J. Yao, Y. Yin*. Effects of dietary supplementation with uridine monophosphate on performance and intestinal morphology of weanling piglets. J Anim Sci, 2016, 94:82–86
24.C. Xie, C. Long, X. Wu*, Z., Y. Wang, Y. Yin*. Effect of maternal supplementation with chitosan oligosaccharide on the antioxidant capacity in suckling piglets. J Anim Sci, 2016, 94: 453-456.
25.孟田田，吴信*，刘怡琳，张彬. 硒代蛋氨酸的生物学功能及在蛋鸡生产中的应用. 动物营养学报，2017，29（12）：4281-4286
26.吴 信，孟田田，万 丹，谢春艳，印遇龙*. 硒在畜禽养殖中的应用研究进展.生物技术进展，2017，7（5）：428-432
27.张珂，邓泽元，吴信*. 尿苷对肝脏脂肪代谢的影响研究进展. 生命科学，2016，28(9):986-990
28.王勤华，周锡红，龙次民，谢春艳，李凤娜，陈晓安，印遇龙，吴信*. 日粮添加灰毡毛忍冬藤叶粉对肥育猪血清生化指标与脂肪代谢的影响. 天然产物研究与开发，2016，28：1810-1815，1837
29.Wu X., Wan D., Xie C., Li T., Huang R., Shu X., Ruan Z., Deng Z., Yin Y.. Acute and sub-acute oral toxicological evaluations and mutagenicity of N-carbamylglutamate (NCG). Regul Toxicol Pharm, 2015, 73 (1):296-302.
30.Xie C., Guo X., Long C., Fan Z., Ruan Z., Deng Z., Xiao D., Wu X.*, Yin Y.*. Supplementation of the sow diet with chitosan oligosaccharide during late gestation and lactation affects hepatic gluconeogenesis of suckling piglets. Anim Reprod Sci, 2015, 159：109-117
31.Wan D., Zhou, X. Xie, C., Shu X., Wu X.*, Yin Y.*. Toxicological Evaluation of Ferrous N-carbamylglycinate Chelate: Acute, Sun-acute toxicity and Mutagenicity. Regul Toxicol Pharm. 2015, 73, (2): 644–651
32.吴信，印遇龙*. 单胃动物动态营养及其研究进展. 农业现代化研究. 2015，36(2):316-32
33.郭小云，谢春艳，吴信*，燕富永，周慧琪，李彪，姚娟，邓泽元，阮征，印遇龙. 低聚糖和酵母对母猪泌乳性能及其子代生理生化指标的影响. 动物营养学报，2015，27( 3) : 838-844
34.X. Wu, Y. Zhang, Y. Yin, G. Wu. Role of stress protein 70 in protecting against intestinal mucosal damage. FRONTIERS IN BIOSCIENCE, 2013, 18, 356-365
35.X. Wu, C. Xie, Y. Yin, F. Li, T. Li, R. Huang, Z. Deng. Effect of L-arginine on HSP70 expression in liver in weanling piglets. BMC Veterinary Research, 2013, 9:63.
36.X. Zhou, X. Wu*, Y.L. Yin*, C Zhang, L He. Preventive oral supplementation with glutamine and arginine has beneficial effects on the intestinal mucosa and inflammatory cytokines in endotoxemic rats. Amino Acids, 2012, 43(2): 813-821.
37.X. Wu, Y.L. Yin, Y. Q. Liu, X.D. Liu, Z. Q. Liu, T.J. Li, R.L. Huang, Z. Ruan, and Z.Y. Deng. Effect of dietary arginine and N-carbamoylglutamate supplementation on reproduction and gene expression of eNOS, VEGFA and PlGF1 in placenta in late pregnancy of sows. Anim Reprod Sci, 2012 ,132:187-192
38.X. Wu, Y. Zhang, Z. Liu, T. Li, Y. Yin. Effects of oral supplementation with glutamate or combination of glutamate and N-carbamylglutamate on intestinal mucosa in piglets. J Anim Sci, 2012, 90: 337–339
39.X.D. Liu, X. Wu*, Y.L. Yin*, Y.Q. Liu, M.M. Geng, H.S. Yang, Z. Ruan, R.L. Huang, G.Y. Wu. Effects of dietary L-arginine or N-carbamylglutamate supplementation during late gestation of sows on the miR-15b/16, miR-221/222, VEGFA and eNOS expression in umbilical vein. Amino Acids, 2012, 42(6): 2111-2119.
40.Wu X, Ruan Z, Gao Y, Yin Y, Zhou X, et al. Dietary supplementation with L-arginine and N-carbamylglutamate enhances intestinal growth and heat shock protein 70 expression in weanling pigs fed a corn- and soybean meal-based diet. Amino Acids, 2010, 39: 831-839
41.Wu Xin, Yin* YL, Li TJ, Wang L, Ruan Z., Liu Z, Hou YQ. Different levels of protein on expression of L-Type Amino Acid Transporter-1. Animal, 2010, 4(9)：1518-1521.
42.孙校名，吴信*，印遇龙，舒绪刚. 铁的吸收及其机制的研究. 动物营养学报，2012,24(6):1000-1006
43.刘星达，吴 信*，印遇龙，杨焕胜，李铁军，黄瑞林. 妊娠后期日粮中添加不同水平N-氨甲酰谷氨酸对母猪繁殖性能的影响. 畜牧兽医学报，2011，42 (11): 1550-1555

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近五年主持项目：十三五国家重点研发计划课题、中科院科技服务网络计划(STS计划)项目、十二五国家科技支撑计划子课题项目、国家自然科学基金、湖南省重大专项子项目、大型企业联合研发合作项目（功能性饲料添加剂关键技术的研究与产业化、酵母核苷酸的研究与应用等）、中国科学院国际人才计划项目等。