基本情况
湖南大学，生命医学交叉研究院，教授、博士生导师。Email：jeff-shi@hnu.edu.cn


教育经历
2009.08-2015.08 美国布兰迪斯大学，化学系，Ph.D导师：Bing Xu
2007.09-2009.06 中山大学，高分子化学与物理，硕士，导师：张黎明
2003.09-2007.06 湘潭大学，化学系，导师：王先友


工作经历
2019年-至今 湖南大学，教授
2015.11-2018.11美国国立癌症研究所（NCI，NIH），博士后，导师：Dr. Joel Schneider
2015.08-2015.10美国布兰迪斯大学，博士后，导师：Dr. Bing Xu


研究领域
1）原创多肽药物的开发
2）穿透肽的机制研究及在递送上应用
3）多肽自组装\凝胶化及其生物医学应用


代表论文
1. Shi, J.F.; Schneider J.P.*, De novo design of selective membrane-active peptides via enzymatic control of their conformational bias on the cell surface. Angew. Chem. Int. Ed. 2019, 58, 13706-13710.（热点文章，封面文章）
2. Shi, J.F.; Fichman G.; Schneider J.P.*, Enzymatic Control of the Conformational Landscape of Supramolecular Assembling Peptides. Angew. Chem. Int. Ed. 2018, 57, 11188-11192.
3. Haburcak, R.^#; Shi, J.F.^#; Du, X.; Yuan, D.; Xu, B.*, Ligand-Receptor Interaction Modulates the Energy Landscape of Enzyme-Instructed Self-Assembly of Small Molecules. J. Am. Chem. Soc. 2016, 138,47, . (^#共同一作)
4. Shi, J.; Du, X.; Huang, Y.; Zhou, J.; Yuan, D.; Wu, D.; Zhang, Y.; Haburcak, R.; Epstein, I. R.; Xu, B.*, Ligand-Receptor Interaction Catalyzes the Aggregation of Small Molecules to Induce Cell Necroptosis. J Am Chem Soc, 2015,137, 1, 26-29
5. Shi, J.F.; Xu, B.*, Nanoscale assemblies of small molecules control the fate of cells. Nano Today 2015, 10 (5), 615-630.
6. Yuan, D.^#; Shi, J. F.^#; Du, X. W.; Zhou, N.; Xu, B.*, Supramolecular Glycosylation Accelerates Proteolytic Degradation of Peptide Nanofibrils. J Am Chem Soc, 2015, 137 (32), 10092-10095. (^#共同一作)
7. Shi, J.; Du, X.; Yuan, D.; Haburcak, R.; Wu, D.; Zhou, N.; Xu, B.*, Enzyme transformation to modulate the ligand–receptor interactions between small molecules. Chem Commun 2015, 51 (23), 4899-4901.
8. Shi, J. F.; Du, X. W.; Yuan, D.; Haburcak, R.; Zhou, N.; Xu, B.*, Supramolecular Detoxification of Neurotoxic Nanofibrils of Small Molecules via Morphological Switch. Bioconj. Chem. 2015, 26 (9), 1879-1883.
9. Shi, J.; Du, X.; Yuan, D.; Zhou, J.; Zhou, N.; Huang, Y.; Xu, B.*, d-Amino Acids Modulate the Cellular Response of Enzymatic-Instructed Supramolecular Nanofibers of Small Peptides. Biomacromolecules 2014, 15 (10), 3559-3568.
10. Shi, J.F.; Yuan, D.; Haburcak, R.; Zhang, Q.; Zhao, C.; Zhang, X.; Xu, B.*, Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels. Chemistry – A European Journal 2015, 21 (50), 18047-18051.
11. Shi, J.; Gao, Y.; Yang, Z.; Xu, B.*, Exceptionally small supramolecular hydrogelators based on aromatic–aromatic interactions. Beilstein J. Org. Chem. 2011, 7 (1), 167-172.
12. Shi, J.; Gao, Y.; Zhang, Y.; Pan, Y.; Xu, B.*, Calcium ions to cross-link supramolecular nanofibers to tune the elasticity of hydrogels over orders of magnitude. Langmuir 2011, 27 (23), 14425-14431.
13. Wang, H.; Shi, J.F; Feng, Z.; Zhou, R.; Wang, S.; Rodal, A. A.; Xu, B.*, An in-situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3D Cell Spheroids. Angew. Chem. Int. Ed. 2017, 56 (51), 16297-16301
14. Kuang, Y.; Shi, J.; Li, J.; Yuan, D.; Alberti, K. A.; Xu, Q.; Xu, B.*, Pericellular Hydrogel/Nanonets Inhibit Cancer Cells. Angew. Chem. Int. Ed. 2014, 53 (31), 8104-8107.
15. Gao, Y.; Shi, J.; Yuan, D.; Xu, B.*, Imaging enzyme-triggered self-assembly of small molecules inside live cells. Nat. Commun. 2012, 3, 1033.
16. Du, X.; Zhou, J.; Shi, J.F.; Xu, B.*, Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials. Chem. Rev., 2015, 115, 24, 13165-13307.
17. Li, J.; Kuang, Y.; Shi, J. F.; Zhou, J.; Medina, J. E.; Zhou, R.; Yuan, D.; Yang, C. H.; Wang, H. M.; Yang, Z. M.; Liu, J. F.; Dinulescu, D. M.; Xu, B.*, Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells. Angew Chem Int Ed., 2015, 54 (45), 13307-13311.
18. Zhang, Y.; Zhou, N.; Shi, J.; Pochapsky, S. S.; Pochapsky, T. C.; Zhang, B.; Zhang, X.; Xu, B.*, Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures. Nat commun. 2015, 6, 6165